Lipid
membranes
form
the
primary
structure
of
cell
and
serve
as
configurable
interfaces
across
numerous
applications
including
biosensing
technologies,
antifungal
treatments,
therapeutic
platforms.
Therefore,
modification
lipid
by
additives
has
important
consequences
in
both
biological
processes
practical
applications.
In
this
study,
we
investigated
a
nicotinic-acid–based
gemini
surfactant
(NAGS)
chemically
tunable
molecular
additive
for
modulating
phase
behavior
liposomal
membranes.
We
specifically
focused
on
NAGS
with
hydrocarbon
chains
that
mirror
those
molecules.
By
introducing
to
phosphatidylcholine
lipids
identical
varied
chain
lengths
or
degrees
unsaturation,
demonstrated
effects
headgroup
interactions
mismatch
between
membrane
lipids.
Using
small-angle
X-ray
scattering,
showed
regardless
compatibility
mismatch,
reduced
thickness
packing
density
fluid
Further
observations
fluorescence
microscopy
revealed
emergence
ordered-disordered
domains
upon
cooling
room
temperature.
The
observed
phases
were
quite
distinct
from
analogous
compositions,
emphasizing
importance
chemistry
mediating
domain
formation
stabilization.
These
findings
open
new
possibilities
exploiting
tuning
organization
potential
drug
delivery
biomedical
imaging.
ACS Infectious Diseases,
Год журнала:
2023,
Номер
9(6), С. 1206 - 1220
Опубликована: Май 10, 2023
During
previous
stages
of
research,
high
biocidal
activity
toward
microorganism
archival
strains
has
been
used
as
the
main
indicator
in
development
new
antiseptic
formulations.
Although
this
factor
remains
one
most
important
characteristics
biocide
efficiency,
scale
antimicrobial
resistance
spread
causes
serious
concern.
Therefore,
focus
shifts
formulations
with
a
stable
effect
even
case
prolonged
contact
pathogens.
Here,
we
introduce
an
original
isocyanuric
acid
alkylation
method
use
available
alkyl
dichlorides,
which
opened
access
to
wide
panel
multi-QACs
chains
various
lengths
between
nitrogen
atoms
triazine
and
pyridine
cycles.
We
complex
approach
for
resulting
series
17
compounds,
including
their
antibiofilm
properties,
bacterial
tolerance
development,
multiresistant
pathogenic
strains.
As
result
these
efforts,
compounds
have
shown
higher
levels
antibacterial
against
ESKAPE
pathogens
than
widely
commercial
QACs.
Hit
possessed
clinical
also
demonstrated
long-term
without
significant
tolerance.
The
overall
results
indicated
level
broad
application
prospects
based
on
Scientific Reports,
Год журнала:
2023,
Номер
13(1)
Опубликована: Янв. 18, 2023
Recently,
scientist
study
the
role
of
surfactants
for
carbon
steel
corrosion
protection.
In
present
study,
newly
tetra-cationic
surfactant
(CS4:
1,N1'-(ethane-1,2-diyl)
bis
(N1,
N2-didodecyl-N2-(2-
(((E)-3-hydroxy-4-methoxy-benzylidene)amino)ethyl)ethane-1,2-diaminium)
chloride)
based
on
Schiff-base
compound(5,5'-((1E,17E)-2,5,8,11,14,17-hexaazaoctadeca-1,17-diene-1,18-diyl)bis(2-methoxyphenol)
was
synthesised,
purified
and
characterized
using
FTIR
1HNMR
spectroscopy.
The
synthesized
Tetra-cationic
(CS4)
evaluated
as
anti-corrosion
(CS-metal)
in
aggressive
1
M
HCl
electrochemical
impedance
spectroscopy
(EIS)
potentiodynamic
polarization
techniques
(PDP).
CS4
compound
had
a
good
surface-active
property
by
reducing
surface
tension
result
to
hydrophobic
chains
role.
prepared
behaved
hybrid
inhibitor
(mixed-type)
blocking
anodic
cathodic
sites.
exhibited
inhibition
efficiency
reached
95.69%.
morphology
CS-metal
studied
scanning
electron
microscopy
(SEM)
X-ray
photoelectron
(XPS)confirming
anti-corrosive
effect
returned
into
adsorption
process
molecules
over
which
obeyed
Langmuir
isotherm.
inhibitive
supported
theoretical
quantum
chemical
studies
density
functional
theory
(DFT),
Monte
Carlo
(MC)
Molecular
Dynamic
(MD)
simulation.
Molecules,
Год журнала:
2024,
Номер
29(8), С. 1725 - 1725
Опубликована: Апрель 11, 2024
The
use
of
surfactants
in
oil
recovery
can
effectively
improve
crude
rate.
Due
to
the
enhanced
salt
and
temperature
resistance
surfactant
molecules
by
non-ionic
chain
segments,
anionic
groups
have
good
emulsifying
stability.
Currently,
there
are
many
studies
on
for
China,
but
is
relatively
little
systematic
research
introducing
EOs
into
hydrophobic
alkyl
chains,
especially
their
self-assembly
behavior.
This
article
proposes
a
simple
effective
synthesis
method,
using
3-aminopropane
sulfonic
acid,
fatty
alcohol
polyoxyethylene
ether,
epichlorohydrin
as
raw
materials,
insert
EO
chains
synthesize
series
new
Gemini
(CnEO-5,
n
=
8,
12,
16).
surface
activity,
thermodynamic
properties,
behavior
these
were
systematically
studied
through
tension,
conductivity,
steady-state
fluorescence
probes,
transmission
electron
microscopy,
molecular
dynamics
simulations.
tension
test
results
show
that
CnEO-5
has
high
activity
higher
than
traditional
single
structurally
similar
surfactants.
Additionally,
parameters
(e.g.,
ΔG°mic
ΔH°mic
ΔS°mic
et
al.
indicate
exothermic
spontaneous
during
micellization
process.
DLS,
p-values,
TEM
with
shorter
(such
C8EO-5)
tend
form
larger
vesicles
aqueous
solutions,
which
formed
tail
staggered
manner;
Negative
longer
C12EO-5,
C16EO-5)
small
micelles.
certain
application
prospects
improving
recovery.
Langmuir,
Год журнала:
2022,
Номер
38(16), С. 4921 - 4934
Опубликована: Апрель 11, 2022
Novel
cationic
amphiphiles
of
the
3-alkyl-1-(4-methoxyphenyl)-1H-imidazol-3-ium
bromide
series
bearing
methoxyphenyl
fragments
(MPI-n)
have
been
synthesized.
Their
aggregation
properties
in
aqueous
solutions,
solubilization
capacity,
and
hemolytic
antimicrobial
activities
investigated
by
a
number
physicochemical
methods.
Using
tensiometry,
conductometry,
fluorescence
spectroscopy,
it
was
shown
that
MPI-n
lower
CMCs
than
their
nonfunctionalized
counterparts.
The
unusual
alkyl-chain-length-dependent
morphology
aggregates
is
testified
for
this
homological
series.
Amphiphiles
with
12,
14,
16
alkyl
tails
are
characterized
formation
micellar
aggregates,
while
surfactant
decyl
tail
larger
surface
curvature.
MPI-10
aggregate
rationalized
terms
packing
parameter
consideration
supported
size
measurements
probe
techniques,
which
showed
vesicle-like
close-packing
mode
probably
occur.
exhibited
high
capacity
toward
hydrophobic
azo
dye
Orange
OT.
Importantly,
studied
(i)
bacteriostatic
activity
at
level
ciprofloxacin;
(ii)
bactericidal
action
against
all
Gram-positive
bacteria,
including
methicillin-resistant
strains;
(iii)
Gram-negative
bacteria;
(iv)
low
activity.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(15), С. 12312 - 12312
Опубликована: Авг. 1, 2023
A
synthesis
procedure
and
aggregation
properties
of
a
new
homologous
series
dicationic
gemini
surfactants
with
dodecane
spacer
two
carbamate
fragments
(N,N'-dialkyl-N,N'-bis(2-(ethylcarbamoyloxy)ethyl)-N,N'-dimethyldodecan-1,6-diammonium
dibromide,
n-12-n(Et),
where
n
=
10,
12,
14)
were
comprehensively
described.
The
critical
micelle
concentrations
obtained
using
tensiometry,
conductometry,
spectrophotometry,
fluorimetry.
thermodynamic
parameters
adsorption
micellization,
i.e.,
maximum
surface
excess
(Гmax),
the
area
per
surfactant
molecule
(Amin),
degree
counterion
binding
(β),
Gibbs
free
energy
micellization
(∆Gmic),
calculated.
Functional
activity
surfactants,
including
solubilizing
capacity
toward
Orange
OT
indomethacin,
incorporation
into
lipid
bilayer,
minimum
inhibitory
concentration,
bactericidal
fungicidal
concentrations,
was
determined.
Synthesized
further
used
for
modification
liposomes
dual-loaded
α-tocopherol
donepezil
hydrochloride
intranasal
treatment
Alzheimer's
disease.
have
high
stability
(more
than
5
months),
significant
positive
charge
(approximately
+
40
mV),
encapsulation
efficiency
rhodamine
B,
α-tocopherol,
hydrochloride.
Korsmeyer-Peppas,
Higuchi,
first-order
kinetic
models
to
process
in
vitro
release
curves
Intranasal
administration
loaded
21
days
prevented
memory
impairment
decreased
number
Aβ
plaques
by
37.6%,
40.5%,
72.6%
entorhinal
cortex,
DG,
CA1
areas
hippocampus
brain
transgenic
mice
disease
model
(APP/PS1)
compared
untreated
animals.
