Signal Transduction and Targeted Therapy,
Год журнала:
2025,
Номер
10(1)
Опубликована: Март 5, 2025
The
successful
approval
of
peptide-based
drugs
can
be
attributed
to
a
collaborative
effort
across
multiple
disciplines.
integration
novel
drug
design
and
synthesis
techniques,
display
library
technology,
delivery
systems,
bioengineering
advancements,
artificial
intelligence
have
significantly
expedited
the
development
groundbreaking
drugs,
effectively
addressing
obstacles
associated
with
their
character,
such
as
rapid
clearance
degradation,
necessitating
subcutaneous
injection
leading
increasing
patient
discomfort,
ultimately
advancing
translational
research
efforts.
Peptides
are
presently
employed
in
management
diagnosis
diverse
array
medical
conditions,
diabetes
mellitus,
weight
loss,
oncology,
rare
diseases,
additionally
garnering
interest
facilitating
targeted
platforms
advancement
vaccines.
This
paper
provides
an
overview
present
market
clinical
trial
progress
therapeutics,
platforms,
It
examines
key
areas
through
literature
analysis
emphasizes
structural
modification
principles
well
recent
advancements
screening,
design,
technologies.
accelerated
including
peptide-drug
complexes,
new
vaccines,
innovative
diagnostic
reagents,
has
potential
promote
era
precise
customization
disease
therapeutic
schedule.
Advanced Drug Delivery Reviews,
Год журнала:
2023,
Номер
200, С. 115047 - 115047
Опубликована: Авг. 2, 2023
RNA
therapeutics
offer
great
potential
to
transform
the
biomedical
landscape,
encompassing
treatment
of
hereditary
conditions
and
development
better
vaccines.
However,
delivery
RNAs
into
cell
is
hampered,
among
others,
by
poor
endosomal
escape.
This
major
hurdle
often
tackled
using
special
lipids,
polymers,
or
protein-based
vectors.
In
this
review,
we
will
focus
on
most
prominent
peptide-
escape
strategies
with
drugs.
We
discuss
penetrating
peptides,
which
are
still
incorporated
novel
transfection
systems
today
promote
direct
evidence
for
enhanced
action
such
peptides
missing
their
efficiency,
even
in
permissive
culture
conditions,
rather
low.
Endosomal
help
pore
forming
proteins
phospholipases,
other
hand,
allowed
generate
more
efficient
systems.
These
are,
however,
hampered
considerable
toxicity
immunogenicity.
conclude
that
perfect
enhancer
has
yet
be
devised.
To
increase
chances
success,
any
new
system
should
tested
under
relevant
guided
assays
allow
quantification
Molecular Pharmaceutics,
Год журнала:
2024,
Номер
21(5), С. 2081 - 2096
Опубликована: Апрель 17, 2024
Small
interfering
RNAs
(siRNAs)
are
promising
therapeutic
strategies,
and
five
siRNA
drugs
have
been
approved
by
the
Food
Drug
Administration
(FDA)
European
Commission
(EC).
This
marks
a
significant
milestone
in
development
of
for
clinical
applications.
The
agents
can
effectively
deliver
siRNAs
to
liver
treat
liver-related
diseases.
Currently,
researchers
developed
diverse
delivery
platforms
transporting
different
tissues
such
as
brain,
lung,
muscle,
others,
large
number
undergoing
trials.
Here,
these
technologies
latest
advancements
applications
summarized,
this
Review
provides
concise
overview
strategies
employed
both
hepatic
extrahepatic
tissues.
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 20, 2024
Tumor
necrosis
factor-α
(TNF-α)
plays
a
causal
role
in
the
pathogenesis
of
ulcerative
colitis
(UC),
and
anti-TNF-α
siRNA
shows
great
promise
UC
therapy.
However,
delivering
with
site-targeted
stability
therapeutic
efficacy
is
still
challenging
due
to
complex
dynamic
intestinal
microenvironment.
Here,
based
on
functional
plant-derived
ginger
extracellular
vesicles
(EVs)
porous
ZIF-8
nanoparticles,
we
propose
novel
TNF-α
delivery
strategy
(EVs@ZIF-8@siRNA)
for
targeted
Ginger
EVs
show
strong
colon
macrophage
targeting,
as
well
robust
resistance
acidic
degradation
stomach.
Moreover,
6-shogaol
ginger-derived
displays
anti-inflammatory
effects,
which
enhance
treatment
efficiency
by
cooperation
siRNA.
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
12(17), С. 4080 - 4096
Опубликована: Янв. 1, 2024
An
illustrative
depiction
highlighting
the
targeted
drug
delivery
mechanism
by
bio-functionalized
camouflaged
MOF
nanocarriers
that
enhances
precision
targeting
diseased
cells
and
minimizing
side
effects.
