Multifaceted Therapeutic Potential of Plant-Derived Exosomes: Immunomodulation, Anticancer, Anti-Aging, Anti-Melanogenesis, Detoxification, and Drug Delivery
Biomolecules,
Год журнала:
2025,
Номер
15(3), С. 394 - 394
Опубликована: Март 10, 2025
Most
eukaryotic
and
prokaryotic
cells
have
the
potential
to
secrete
a
group
of
structures/membrane-bound
organelles,
collectively
referred
as
extracellular
vesicles
(EVs),
which
offer
several
advantages
producer/receiver
cells.
This
review
provides
an
overview
EVs
from
plant
sources
with
emphasis
on
their
health-promoting
possible
use
therapeutic
agents.
highlights
essential
biological
effects
plant-derived
vesicles,
including
immune
modulation,
anticancer
activities,
protection
against
chemical
toxicity
pathogens,
well
anti-aging,
anti-melanogenesis,
anti-arthritic
effects,
along
ongoing
clinical
studies.
Evidence
revealed
that
EVs’
contents
exert
beneficial
properties
through
regulating
important
signaling
pathways
by
transferring
miRNAs
other
components.
Taken
all
together,
data
proposed
can
be
utilized
nutritional
compounds
agents,
such
drug
carriers.
However,
this
emerging
research
area
requires
further
in
vitro/in
vivo
studies
trials
determine
exact
underlying
mechanisms
positive
health
treating
various
diseases.
Язык: Английский
ZIF-8/doxorubicin nanoparticles camouflaged with Cucurbita-derived exosomes for targeted prostate cancer therapy
Journal of Materials Chemistry B,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Biomimetic
ZIF-8/DOX
nanoparticles,
coated
with
Cucurbita
-derived
exosomes
and
functionalized
EpCAM
aptamer,
were
developed
to
enhance
biocompatibility
immune
evasion,
leading
targeted
prostate
cancer
therapy.
Язык: Английский
Functionalized ZIF-8 as a versatile platform for drug delivery and cancer therapy: strategies, challenges and prospects
Wenyue Gao,
Xinping Han,
Ling Li
и другие.
Journal of Materials Chemistry B,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
This
review
discusses
the
functionalization
strategies
of
ZIF-8
and
challenges
future
developments
in
ZIF-8-based
platforms
for
drug
delivery
cancer
therapy.
Язык: Английский
Plant extracellular vesicles: A promising bionic medicine platform for disease treatment and drug delivery
Deleted Journal,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 20, 2025
Abstract
Plant
extracellular
vesicles
(PEVs)
are
nanoscale
secreted
by
plant
cells
with
intact
membrane
architecture,
which
encapsulate
a
diverse
array
of
biomolecules,
including
lipids,
proteins
and
RNA.
They
integral
to
both
intra‐cellular
communication
within
plants
inter‐species
signaling.
Recently,
some
PEVs
have
been
regarded
as
competitive
candidates
for
disease
therapy
due
their
beneficial
components
distinctive
hollow
biomembrane
structure.
However,
the
broader
applications
currently
impeded
several
challenges
complicated
extraction
processes,
compositional
heterogeneity,
lack
reliable
biomarkers
unclear
mechanisms.
A
detailed
comprehension
preparation
techniques
biological
functions
is
essential
leveraging
potential
in
clinical
medicine.
This
article
first
presented
synthesis
current
methodologies
PEV
isolation,
purification
characterization.
Then,
it
revealed
therapeutic
implications
medicines
common
diseases
based
on
bioactive
molecules
inside,
such
cancer,
inflammation,
metabolic
disorders.
We
especially
explored
emerging
role
low
immunogenicity
power
barriers
crossing
drug
delivery
systems,
underscoring
further
industry
applications.
At
last,
bottleneck
problems
vision
were
also
evoke
more
insightful
deliberation.
review
aims
provide
directions
development
PEV‐derived
innovative
drugs.
Язык: Английский
Engineered Turmeric-Derived Nanovesicles for Ulcerative Colitis Therapy by Attenuating Oxidative Stress and Alleviating Inflammation
Molecular Pharmaceutics,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 26, 2025
Inflammation
and
oxidative
stress
are
important
features
of
traumatic
ulcerative
colitis
(UC).
Turmeric
has
been
used
as
a
dietary
functional
ingredient
for
its
potent
anti-inflammatory
effects
in
UC
therapy.
However,
practical
effectiveness
is
hindered
by
limited
reactive
oxygen
species
(ROS)
elimination
properties.
To
address
this,
we
constructed
unique
treatment
agent
growing
cerium
oxide
(CeO2)
nanocrystals
on
the
membranes
turmeric-derived
nanovesicles
(TNVs),
named
TNV-Ce.
The
resulted
TNV-Ce
could
suppress
inflammation
exhibit
exceptional
ROS-scavenging
activity,
which
was
validated
both
lipopolysaccharide-induced
macrophages
dextran
sulfate
sodium
salt-induced
chronic
mouse
model.
Following
oral
administration,
significantly
accumulated
at
inflamed
sites,
effectively
eliminating
ROS
inhibiting
pro-inflammatory
cytokines
synergistic
action
against
UC.
Язык: Английский
A multifaceted microenvironment nanonanoregulator for targeted ovarian cancer therapy
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Март 27, 2025
The
treatment
of
ovarian
cancer
is
hindered
by
its
insidious
onset
and
rapid
progression.
Exosomes
(EXOs)
present
a
promising
therapeutic
strategy
for
modulating
the
tumor
microenvironment.
However,
concerns
regarding
biosafety
animal-derived
EXOs
pose
significant
challenges
to
development
innovative
formulations.
In
this
study,
we
propose
universal
engineer
plant-derived
as
microenvironment
nanoregulators
targeted
therapy.
derived
from
ginger
were
purified,
loaded
with
natural
bioactive
compound
curcumin
(Cur)
high
encapsulation
efficiency,
functionalized
tumor-targeting
aptamer.
Upon
intravenous
administration,
resulting
multifaceted
nanoregulator,
termed
AGE@Cur,
effectively
accumulates
at
site
exerts
tumor-suppressive
effect
through
remodeling
This
novel
platform
not
only
addresses
limitations
but
also
paves
way
regulators
in
clinical
applications.
Язык: Английский
Advances in plant-derived vesicle like nanoparticles-based therapies for inflammatory diseases
Asian Journal of Pharmaceutical Sciences,
Год журнала:
2025,
Номер
unknown, С. 101052 - 101052
Опубликована: Апрель 1, 2025
Язык: Английский
Extracellular vesicles as vital players in drug delivery: a focus on clinical disease treatment
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2025,
Номер
13
Опубликована: Май 14, 2025
Extracellular
vesicles
(EVs),
a
diverse
population
of
bilayer
lipid-membrane
secreted
by
cells,
have
emerged
as
ideal
drug
carriers
due
to
their
efficient
cellular
uptake
and
targeted
delivery
capabilities.
Advancements
in
medical
bioengineering
collaborations
enabled
EVs
be
engineered
for
specific
marker
expression
or
therapeutic
cargo
transport,
positioning
them
promising
modality
treating
cancer,
neurological
disorders,
cardiovascular
diseases,
beyond.
EV-based
strategies
offer
distinct
advantages,
including
facilitation
intercellular
communication
immune
modulation,
high
biocompatibility
stability,
the
ability
traverse
blood-brain
barrier,
potential
synergistic
interactions
with
encapsulated
therapeutics
enhance
efficacy.
This
review
explores
EV
isolation
scalable
production,
emphasizing
cost-effective
reproducible
manufacturing
strategies,
cargo-loading
methodologies,
applications.
Additionally,
current
landscape
delivery,
clinical
translation
prospects,
prevailing
challenges
are
examined
provide
comprehensive
perspective
on
systems.
Язык: Английский
Morinda Officinalis-Derived Extracellular Vesicle-like Particles Promote Wound Healing via Angiogenesis
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 16, 2025
Wound
healing
is
a
multistage
process,
related
to
complex
cellular
and
molecular
interactions
that
manipulate
the
cell
behaviors
promote
regeneration
repair
of
skin.
Interestingly,
plant-derived
extracellular
vesicles-like
particles
(EVs)
show
great
potential
as
preparations
for
skin
diseases.
In
this
study,
vesicle-like
derived
from
Morinda
Officinalis
(MOEVLPs)
were
isolated
effectively
promoted
proliferation,
migration,
tube
formation
endothelial
cells
in
vitro.
Mechanistically,
MOEVLPs
significantly
activated
MAPK/YAP1
signaling
pathway,
confirmed
by
proteomics
analysis
immunofluorescence
staining,
with
an
increase
YAP1
expression
level
full-thickness
wound
model.
Subsequently,
further
integrated
into
hydrogel
carrier,
enabling
them
affect
microenvironments
accelerate
at
level.
The
functional
exhibited
prolonged
release
MOEVLPs,
promoting
angiogenesis
vivo,
which
provided
promising
strategy
clinical
applications
advanced
healthcare.
Язык: Английский