Morinda Officinalis-Derived Extracellular Vesicle-like Particles Promote Wound Healing via Angiogenesis DOI
Qing Zhao,

Qin-Xiao Hu,

Jianping Li

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Май 16, 2025

Wound healing is a multistage process, related to complex cellular and molecular interactions that manipulate the cell behaviors promote regeneration repair of skin. Interestingly, plant-derived extracellular vesicles-like particles (EVs) show great potential as preparations for skin diseases. In this study, vesicle-like derived from Morinda Officinalis (MOEVLPs) were isolated effectively promoted proliferation, migration, tube formation endothelial cells in vitro. Mechanistically, MOEVLPs significantly activated MAPK/YAP1 signaling pathway, confirmed by proteomics analysis immunofluorescence staining, with an increase YAP1 expression level full-thickness wound model. Subsequently, further integrated into hydrogel carrier, enabling them affect microenvironments accelerate at level. The functional exhibited prolonged release MOEVLPs, promoting angiogenesis vivo, which provided promising strategy clinical applications advanced healthcare.

Язык: Английский

Multifaceted Therapeutic Potential of Plant-Derived Exosomes: Immunomodulation, Anticancer, Anti-Aging, Anti-Melanogenesis, Detoxification, and Drug Delivery DOI Creative Commons
Arzu Zeynep Karabay, Jaleh Barar, Yalda Hekmatshoar

и другие.

Biomolecules, Год журнала: 2025, Номер 15(3), С. 394 - 394

Опубликована: Март 10, 2025

Most eukaryotic and prokaryotic cells have the potential to secrete a group of structures/membrane-bound organelles, collectively referred as extracellular vesicles (EVs), which offer several advantages producer/receiver cells. This review provides an overview EVs from plant sources with emphasis on their health-promoting possible use therapeutic agents. highlights essential biological effects plant-derived vesicles, including immune modulation, anticancer activities, protection against chemical toxicity pathogens, well anti-aging, anti-melanogenesis, anti-arthritic effects, along ongoing clinical studies. Evidence revealed that EVs’ contents exert beneficial properties through regulating important signaling pathways by transferring miRNAs other components. Taken all together, data proposed can be utilized nutritional compounds agents, such drug carriers. However, this emerging research area requires further in vitro/in vivo studies trials determine exact underlying mechanisms positive health treating various diseases.

Язык: Английский

Процитировано

2

ZIF-8/doxorubicin nanoparticles camouflaged with Cucurbita-derived exosomes for targeted prostate cancer therapy DOI
Adeleh Saffar, Ahmad Reza Bahrami, Amir Sh. Saljooghi

и другие.

Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Biomimetic ZIF-8/DOX nanoparticles, coated with Cucurbita -derived exosomes and functionalized EpCAM aptamer, were developed to enhance biocompatibility immune evasion, leading targeted prostate cancer therapy.

Язык: Английский

Процитировано

1

Functionalized ZIF-8 as a versatile platform for drug delivery and cancer therapy: strategies, challenges and prospects DOI

Wenyue Gao,

Xinping Han,

Ling Li

и другие.

Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

This review discusses the functionalization strategies of ZIF-8 and challenges future developments in ZIF-8-based platforms for drug delivery cancer therapy.

Язык: Английский

Процитировано

0

Plant extracellular vesicles: A promising bionic medicine platform for disease treatment and drug delivery DOI Creative Commons
Jichun Yang, Yuhan Wang,

Yunqian Fu

и другие.

Deleted Journal, Год журнала: 2025, Номер unknown

Опубликована: Март 20, 2025

Abstract Plant extracellular vesicles (PEVs) are nanoscale secreted by plant cells with intact membrane architecture, which encapsulate a diverse array of biomolecules, including lipids, proteins and RNA. They integral to both intra‐cellular communication within plants inter‐species signaling. Recently, some PEVs have been regarded as competitive candidates for disease therapy due their beneficial components distinctive hollow biomembrane structure. However, the broader applications currently impeded several challenges complicated extraction processes, compositional heterogeneity, lack reliable biomarkers unclear mechanisms. A detailed comprehension preparation techniques biological functions is essential leveraging potential in clinical medicine. This article first presented synthesis current methodologies PEV isolation, purification characterization. Then, it revealed therapeutic implications medicines common diseases based on bioactive molecules inside, such cancer, inflammation, metabolic disorders. We especially explored emerging role low immunogenicity power barriers crossing drug delivery systems, underscoring further industry applications. At last, bottleneck problems vision were also evoke more insightful deliberation. review aims provide directions development PEV‐derived innovative drugs.

Язык: Английский

Процитировано

0

Engineered Turmeric-Derived Nanovesicles for Ulcerative Colitis Therapy by Attenuating Oxidative Stress and Alleviating Inflammation DOI
Guihong Lu,

Shanming Lu,

Haibing Dai

и другие.

Molecular Pharmaceutics, Год журнала: 2025, Номер unknown

Опубликована: Март 26, 2025

Inflammation and oxidative stress are important features of traumatic ulcerative colitis (UC). Turmeric has been used as a dietary functional ingredient for its potent anti-inflammatory effects in UC therapy. However, practical effectiveness is hindered by limited reactive oxygen species (ROS) elimination properties. To address this, we constructed unique treatment agent growing cerium oxide (CeO2) nanocrystals on the membranes turmeric-derived nanovesicles (TNVs), named TNV-Ce. The resulted TNV-Ce could suppress inflammation exhibit exceptional ROS-scavenging activity, which was validated both lipopolysaccharide-induced macrophages dextran sulfate sodium salt-induced chronic mouse model. Following oral administration, significantly accumulated at inflamed sites, effectively eliminating ROS inhibiting pro-inflammatory cytokines synergistic action against UC.

Язык: Английский

Процитировано

0

A multifaceted microenvironment nanonanoregulator for targeted ovarian cancer therapy DOI Creative Commons
Yizheng Zu, Min Li, R. Li

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Март 27, 2025

The treatment of ovarian cancer is hindered by its insidious onset and rapid progression. Exosomes (EXOs) present a promising therapeutic strategy for modulating the tumor microenvironment. However, concerns regarding biosafety animal-derived EXOs pose significant challenges to development innovative formulations. In this study, we propose universal engineer plant-derived as microenvironment nanoregulators targeted therapy. derived from ginger were purified, loaded with natural bioactive compound curcumin (Cur) high encapsulation efficiency, functionalized tumor-targeting aptamer. Upon intravenous administration, resulting multifaceted nanoregulator, termed AGE@Cur, effectively accumulates at site exerts tumor-suppressive effect through remodeling This novel platform not only addresses limitations but also paves way regulators in clinical applications.

Язык: Английский

Процитировано

0

Advances in plant-derived vesicle like nanoparticles-based therapies for inflammatory diseases DOI Creative Commons
Zhifei Cheng, Wenbo Lu, Wei Shao

и другие.

Asian Journal of Pharmaceutical Sciences, Год журнала: 2025, Номер unknown, С. 101052 - 101052

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0

Extracellular vesicles as vital players in drug delivery: a focus on clinical disease treatment DOI Creative Commons

T.L. Chen,

Dan Chen,

Wanting Su

и другие.

Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 13

Опубликована: Май 14, 2025

Extracellular vesicles (EVs), a diverse population of bilayer lipid-membrane secreted by cells, have emerged as ideal drug carriers due to their efficient cellular uptake and targeted delivery capabilities. Advancements in medical bioengineering collaborations enabled EVs be engineered for specific marker expression or therapeutic cargo transport, positioning them promising modality treating cancer, neurological disorders, cardiovascular diseases, beyond. EV-based strategies offer distinct advantages, including facilitation intercellular communication immune modulation, high biocompatibility stability, the ability traverse blood-brain barrier, potential synergistic interactions with encapsulated therapeutics enhance efficacy. This review explores EV isolation scalable production, emphasizing cost-effective reproducible manufacturing strategies, cargo-loading methodologies, applications. Additionally, current landscape delivery, clinical translation prospects, prevailing challenges are examined provide comprehensive perspective on systems.

Язык: Английский

Процитировано

0

Morinda Officinalis-Derived Extracellular Vesicle-like Particles Promote Wound Healing via Angiogenesis DOI
Qing Zhao,

Qin-Xiao Hu,

Jianping Li

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Май 16, 2025

Wound healing is a multistage process, related to complex cellular and molecular interactions that manipulate the cell behaviors promote regeneration repair of skin. Interestingly, plant-derived extracellular vesicles-like particles (EVs) show great potential as preparations for skin diseases. In this study, vesicle-like derived from Morinda Officinalis (MOEVLPs) were isolated effectively promoted proliferation, migration, tube formation endothelial cells in vitro. Mechanistically, MOEVLPs significantly activated MAPK/YAP1 signaling pathway, confirmed by proteomics analysis immunofluorescence staining, with an increase YAP1 expression level full-thickness wound model. Subsequently, further integrated into hydrogel carrier, enabling them affect microenvironments accelerate at level. The functional exhibited prolonged release MOEVLPs, promoting angiogenesis vivo, which provided promising strategy clinical applications advanced healthcare.

Язык: Английский

Процитировано

0