Bacterial
resistance
to
antibiotics
has
rendered
bacterial
infections
an
escalating
threat
public
health,
prompting
numerous
researchers
strive
towards
the
development
of
novel
antimicrobial
agents.
Designable
ionic
liquids
(ILs)
have
gained
increasing
prominence
in
field
antibacterials.
However,
certain
ILs
exhibit
suboptimal
activity
and
limited
biocompatibility.
In
this
study,
we
synthesized
liquid-derived
carbon
dots
(IL-CDs)
through
vinyl
epoxy
group
reactions,
resulting
enhanced
efficacy
favorable
The
IL-CDs
retain
antibacterial
structure
characteristic
ILs,
including
a
positively
charged
imidazole
long
alkyl
chain.
Moreover,
demonstrate
selective
action
against
Staphylococcus
aureus
(S.
aureus)
while
effectively
inhibiting
S.
biofilm
growth.
Notably,
superior
potency
compared
commercially
available
quaternary
ammonium
salt-based
We
conducted
comprehensive
investigations
into
mechanism
which
primarily
involves
electrostatic
interactions,
hydrophobic
as
well
generation
reactive
oxygen
species
(ROS)
within
bacteria
cells.
vivo
experiments
demonstrated
that
significantly
alleviate
inflammation
expedite
wound
healing
aureus-infected
mice
models;
thus
highlighting
their
potential
therapeutic
candidates
for
diseases
resembling
infection-like
conditions.
Importantly,
our
work
presents
approach
utilizing
IL-based
materials
developing
effective
antibacterials
thereby
offering
new
insights
application
prospects
IL-derived
materials.
Molecules,
Год журнала:
2024,
Номер
29(15), С. 3482 - 3482
Опубликована: Июль 25, 2024
Nanoparticles
are
structures
that
possess
unique
properties
with
high
surface
area-to-volume
ratio.
Their
small
size,
up
to
100
nm,
and
potential
for
modifications
have
enabled
their
use
in
a
wide
range
of
applications.
Various
factors
influence
the
applications
NPs,
including
synthesis
method
physical
attributes
such
as
size
shape.
Additionally,
materials
used
NPs
primary
determinants
application.
Based
on
chosen
material,
generally
classified
into
three
categories:
organic,
inorganic,
carbon-based.
These
categories
include
variety
materials,
proteins,
polymers,
metal
ions,
lipids
derivatives,
magnetic
minerals,
so
on.
Each
material
possesses
activity
application
NPs.
Consequently,
certain
typically
particular
areas
because
they
higher
efficiency
along
tenable
toxicity.
Therefore,
classification
base
NP
hold
significant
importance
both
research
In
this
paper,
we
discuss
these
classifications,
exemplify
most
major
categorize
them
according
preferred
area
This
review
provides
an
overall
application,
Pharmaceutics,
Год журнала:
2024,
Номер
16(2), С. 229 - 229
Опубликована: Фев. 5, 2024
This
review
is
concerned
with
chronic
wounds,
an
emphasis
on
biofilm
and
its
complicated
management
process.
The
basics
of
antimicrobial
photodynamic
therapy
(PDT)
underlying
mechanisms
for
microbial
eradication
are
presented.
Intrinsically
active
nanocarriers
(polydopamine
NPs,
chitosan
polymeric
micelles)
that
can
further
potentiate
the
effect
discussed.
also
delves
into
role
photoactive
electrospun
nanofibers,
either
in
their
eluting
or
non-eluting
mode
action,
accelerating
healing
wounds.
Synergic
strategies
to
augment
PDT-mediated
nanofibers
reviewed.
Biomaterials Science,
Год журнала:
2024,
Номер
12(15), С. 3745 - 3764
Опубликована: Янв. 1, 2024
Hydrogels,
as
an
emerging
biomaterial,
have
found
extensive
use
in
the
healing
of
wounds
due
to
their
distinctive
physicochemical
structure
and
functional
properties.
Moreover,
hydrogels
can
be
made
match
a
range
therapeutic
requirements
for
materials
used
wound
through
specific
modifications.
This
review
provides
step-by-step
explanation
processes
involved
cutaneous
healing,
including
hemostasis,
inflammation,
proliferation,
reconstitution,
along
with
investigation
factors
that
impact
these
processes.
Furthermore,
thorough
analysis
is
conducted
on
various
stages
process
at
which
are
implemented,
anti-infection
measures,
encouraging
regeneration,
scar
reduction,
monitoring.
Next,
latest
progress
multifunctional
methods
achieve
functions
discussed
depth
categorized
elucidation.
Finally,
perspectives
challenges
associated
clinical
applications
discussed.
