Shijie huaren xiaohua zazhi, Год журнала: 2024, Номер 32(12), С. 865 - 871
Опубликована: Дек. 28, 2024
Язык: Английский
Chemical Engineering Journal, Год журнала: 2024, Номер 496, С. 153803 - 153803
Опубликована: Июль 6, 2024
Язык: Английский
Процитировано
27
Journal of Translational Medicine, Год журнала: 2025, Номер 23(1)
Опубликована: Март 7, 2025
Antibiotic resistance is currently one of the most significant threats to global public health and safety. And studies have found that over next 25 years, 39 million people will die directly 169 indirectly due antibiotic-resistant diseases. Consequently, development new types antimicrobial drugs urgently needed. Antimicrobial peptides (AMPs) constitute an essential component innate immune response in all organisms. They exhibit a distinctive mechanism action endows them with broad spectrum biological activities, including antimicrobial, antibiofilm, antiviral, anti-inflammatory effects. However, AMPs also present certain limitations, such as cytotoxicity, susceptibility protein hydrolysis, poor pharmacokinetic properties, which impeded their clinical application. The delivery systems can address these challenges by modifying AMP enabling precise, controlled release at site infection or disease. This review offers comprehensive analysis mechanisms advantages AMPs. systematically evaluate how emerging drug systems, nanoparticles hydrogels, enhance stability bioavailability AMPs, discussing both strengths limitations. Moreover, unlike previous reviews, this highlight recent clinically approved AMP-based those development, emphasizing key translating into practice. With perspectives, it hoped provide some insights overcoming translational barriers advancing
Язык: Английский
Процитировано
5
Antibiotics, Год журнала: 2024, Номер 13(9), С. 794 - 794
Опубликована: Авг. 23, 2024
The emergence of drug resistance genes and the detrimental health effects caused by overuse antibiotics are increasingly prominent problems. There is an urgent need for effective strategies to or antimicrobial in fields biomedicine therapeutics. pathogen-killing ability peptides (AMPs) linked their structure physicochemical properties, including conformation, electrical charges, hydrophilicity, hydrophobicity. AMPs a form innate immune protection found all life forms. A key aspect application involves potential combat emerging antibiotic resistance; certain against resistant microbial strains can be modified through peptide engineering. This review summarizes various used tackle resistance, with particular focus on role as agents that enhance host’s immunological functions. Most recent studies properties impregnation methods AMPs, along biomedical applications, discussed. provides researchers insights into latest advancements AMP research, highlighting compelling evidence effectiveness agents.
Язык: Английский
Процитировано
13
Aggregate, Год журнала: 2025, Номер unknown
Опубликована: Апрель 22, 2025
ABSTRACT Recent advancements in hydrogel‐based flexible materials have revolutionized wound healing and monitoring strategies. These offer promising solutions for medical treatment real‐time diagnostics. Their rich water content, biocompatibility, tunable properties closely mimic the natural extracellular matrix, supporting regeneration. Unlike traditional materials, systems address critical issues such as material stability toxicity while integrating advanced devices. This review highlights latest innovations materials. It focuses on flexibility, potential integration with smart systems. The covers design principles fabrication techniques nanofibers, elastomers, conducting polymers. also discusses development of electronic skin innovative dressings. In addition, explains how sensing capabilities, stimuli‐responsive functions, antibacterial agents are incorporated into these Finally, article examines challenges future directions field. emphasizes transformative multifunctional improving continuous monitoring.
Язык: Английский
Процитировано
1
Gels, Год журнала: 2024, Номер 10(8), С. 495 - 495
Опубликована: Июль 26, 2024
Bacterial infection treatment for chronic wounds has posed a major medical threat and challenge. Bacteria at the wounded sites can compete with immune system subsequently invade live tissues, leading to more severe tissue damage. Therefore, there is an urgent demand wound dressings antibacterial anti-inflammatory properties. Considering concept of moist healing, hydrogels three-dimensional (3D) network structure are widely used as due their excellent hydrophilicity, water retention properties, biocompatibility. Developing infected been receiving extensive attention recently. This article categorizes according materials modes, introduces recent findings progress regarding status. More importantly, development emerging technologies, new therapies utilized prepare such nanoenzymes, photothermal therapy (PTT), photodynamic (PDT), metal–organic frameworks (MOFs), other external stimuli-responsive methods. this review also examines progress, challenges, future trends dressings. In following studies, will still be focus on that have high performance, multi-functions, intelligence, especially biocompatibility, long-lasting property, responsiveness, on-demand therapeutic ability.
Язык: Английский
Процитировано
8
Science China Materials, Год журнала: 2024, Номер unknown
Опубликована: Сен. 10, 2024
Язык: Английский
Процитировано
7
ACS Applied Nano Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 27, 2025
Язык: Английский
Процитировано
0
Advanced Functional Materials, Год журнала: 2025, Номер unknown
Опубликована: Март 17, 2025
Abstract Hydrogel wound dressings are appealing for managing injuries due to their multifunctional properties. The adhesive nature allows them cover complex shapes, stop bleeding quickly, and eliminate the need invasive procedures. However, adhesion can be compromised by water molecules from exudates. Furthermore, bacterial infection inflammation remain common challenges in healing. Herein, a poly(ectoine)‐based hydrogel with remarkable wet adhesion, antimicrobial, anti‐inflammatory properties treatment is reported. Poly(ectoine methacrylate) (PEMA) exhibits strong absorption, effectively removing interfacial hydration layer promote binding of catechol groups substrates. incorporation ectoine methacrylate dopamine imparts capabilities, while Jelleine‐I antimicrobial peptide ( J–I AMP) integrated into hydrogel's main chain offers long‐lasting antibacterial effects. In vitro vivo tests demonstrate that this dressing holds potential promoting
Язык: Английский
Процитировано
0
Journal of Functional Biomaterials, Год журнала: 2025, Номер 16(5), С. 174 - 174
Опубликована: Май 12, 2025
Wound healing is a complex, multiphase process crucial for restoring tissue integrity and functionality after injury. Among the emerging therapeutic approaches, antimicrobial peptides (AMPs) have shown substantial promise because of their dual role in microbial defense cellular modulation. AMP-IBP5, novel AMP derived from insulin-like growth factor-binding protein 5, exhibits both wound-healing properties, making it promising candidate. This peptide robust activity, augments keratinocyte proliferation, increases fibroblast migration, induces angiogenesis, modulates immune response. Mechanistically, AMP-IBP5 activates Mas-related G protein-coupled receptors low-density lipoprotein receptor-related 1 (LRP1) keratinocytes, stimulating IL-8 production vascular endothelial factor expression to accelerate wound healing. molecule also interacts with LRP1 fibroblasts increase cell migration promote angiogenesis while mitigating inflammatory responses through targeted cytokine Preclinical studies demonstrated its remarkable efficacy promoting repair diabetic wounds skin conditions, including atopic dermatitis psoriasis. review delves into broad potential across dermatological applications, focusing on intricate mechanisms action, comparative advantages, path toward clinical commercial application.
Язык: Английский
Процитировано
0
Journal of Fluorescence, Год журнала: 2024, Номер unknown
Опубликована: Окт. 15, 2024
Язык: Английский
Процитировано
1