Genes, Год журнала: 2025, Номер 16(3), С. 353 - 353
Опубликована: Март 19, 2025
Background: Nibribacter radioresistens, a UV and gamma radiation-tolerant bacterium, was reported to have superior antibacterial activities against variety of pathogenic bacteria through the production antimicrobial peptides (AMPs), but nothing is known about its AMPs. Methods/Results: In this study, our genomic transcriptomic data showed that N. radioresistens genome contains 11 AMP gene candidates, designated as NB_AMP1 NB_AMP11, which are expressed differently in logarithmic growth stationary phase. Moreover, cell-free supernatant all Escherichia coli DH5α strains containing cloned AMPs except for NB_AMP5 NB_AMP7 exhibited both Gram-negative Gram-positive such E. Staphylococcus aureus. Synthetic supported AMPs, and, particular, synthetic NB_AMP2 S. Conclusions: Altogether, these results suggest candidates from may function peptides, effectively causing cellular lysis pore formation bacterial membrane.
Язык: Английский