Expert Opinion on Drug Delivery,
Год журнала:
2024,
Номер
21(3), С. 381 - 397
Опубликована: Фев. 24, 2024
Research
on
nanotechnology
in
medicine
has
also
involved
the
ocular
field
and
nanomicelles
are
among
applications
developed.
This
approach
is
used
to
increase
both
water
solubility
of
hydrophobic
drugs
their
penetration/permeation
within/through
tissues
since
able
encapsulate
insoluble
drug
into
core
small
size
allows
them
penetrate
and/or
diffuse
through
aqueous
pores
tissues.
The Ocular Surface,
Год журнала:
2023,
Номер
28, С. 213 - 252
Опубликована: Апрель 1, 2023
Eye
strain
when
performing
tasks
reliant
on
a
digital
environment
can
cause
discomfort,
affecting
productivity
and
quality
of
life.
Digital
eye
(the
preferred
terminology)
was
defined
as
"the
development
or
exacerbation
recurrent
ocular
symptoms
and/or
signs
related
specifically
to
device
screen
viewing".
prevalence
up
97%
has
been
reported,
due
no
previously
agreed
definition/diagnostic
criteria
limitations
current
questionnaires
which
fail
differentiate
such
from
those
arising
non-digital
tasks.
Objective
blink
rate
critical
flicker
frequency
changes
are
not
'diagnostic'
nor
validated
sensitive.
The
mechanisms
attributed
surface
disease
mainly
reduced
completeness,
partial/uncorrected
refractive
error
underlying
binocular
vision
anomalies,
together
with
the
cognitive
demand
task
differences
in
position,
size,
brightness
glare
compared
an
equivalent
task.
In
general,
interventions
well
established;
patients
experiencing
should
be
provided
full
correction
for
appropriate
working
distances.
Improving
blinking,
optimizing
work
encouraging
regular
breaks
may
help.
Based
current,
best
evidence,
blue-light
blocking
do
appear
effective
management
strategy.
More
larger
clinical
trials
needed
assess
artificial
tear
effectiveness
relieving
strain,
particularly
comparing
different
constituents;
systematic
review
within
report
identified
use
secretagogues
warm
compress/humidity
goggles/ambient
humidifiers
promising
strategies,
along
nutritional
supplementation
(such
omega-3
fatty
acid
berry
extracts).
International Journal of Pharmaceutics,
Год журнала:
2024,
Номер
662, С. 124510 - 124510
Опубликована: Июль 24, 2024
The
global
shortage
of
corneal
transplants
has
spurred
an
urgency
in
the
quest
for
efficient
treatments.
This
systematic
review
not
only
provides
a
concise
overview
current
landscape
morphology,
physiology,
diseases,
and
conventional
treatments
but
crucially
delves
into
forefront
tissue
engineering
regeneration.
Emphasizing
cellular
acellular
components,
bioprinting
techniques,
pertinent
biological
assays,
it
explores
optimization
strategies
manufacturing
cost-effectiveness.
To
bridge
gap
between
research
industrial
production,
outlines
essential
regulatory
strategy
required
Europe,
encompassing
relevant
directives,
frameworks,
governing
bodies.
comprehensive
framework
spans
entire
process,
from
procuring
initial
components
to
marketing
subsequent
product
surveillance.
In
pivotal
shift
towards
future,
culminates
by
highlighting
latest
advancements
this
sector,
particularly
integration
therapy
with
artificial
intelligence.
synergy
promises
substantial
overall
paving
way
unprecedented
breakthroughs
essence,
elucidates
state
also
pathways
anticipates
transformative
impact
intelligence,
providing
guide
researchers,
practitioners,
policymakers
field.
American Journal Of Pathology,
Год журнала:
2024,
Номер
194(5), С. 810 - 827
Опубликована: Фев. 5, 2024
Corneal
nerve
impairment
contributes
significantly
to
dry
eye
disease
(DED)
symptoms
and
is
thought
be
secondary
corneal
epithelial
damage.
Transient
receptor
potential
vanilloid-1
(TRPV1)
channels
abound
in
fibers
respond
inflammation-derived
ligands,
which
increase
DED.
TRPV1
overactivation
promotes
axonal
degeneration
vitro,
but
whether
it
participates
DED-associated
dysfunction
unknown.
To
explore
this,
DED
was
surgically
induced
wild-type
TRPV1-knockout
mice,
developed
comparable
damage
reduced
tear
secretion.
However,
mechanosensitivity
decreased
progressively
only
mice.
Sensitivity
capsaicin
(TRPV1
agonist)
increased
consistently,
this
strain
displayed
DED-induced
pain
signs.
Wild-type
mice
exhibited
throughout
the
epithelium,
whereas
a
reduction
most
superficial
endings
that
failed
propagate
deeper
subbasal
nerves.
Pharmacologic
blockade
reproduced
these
findings
CD4
