Spektrum der Augenheilkunde, Год журнала: 2023, Номер unknown
Опубликована: Дек. 18, 2023
Язык: Английский
Journal of Clinical Medicine, Год журнала: 2024, Номер 13(3), С. 659 - 659
Опубликована: Янв. 23, 2024
(1) Background: Dry eye disease (DED) is a chronic ocular surface condition that requires precise diagnostic tools. The present study aimed to investigate the potential of absolute inter-eye difference (|OD-OS|) in tear meniscus height (TMH) for detection presence aqueous deficient dry (ADDE). (2) Methods: A sample 260 participants with complaints underwent examinations thorough assessments based on Tear Film and Ocular Surface Society guidelines (TFOS DEWS II). Participants were subsequently categorized as No ADDE TMH. Statistical analyses determine optimal TMH|OD-OS| cut-off value randomly selected group (200 participants) performed, while separate validation analysis obtained random cross-validation (60 was also performed. (3) Results: significant capability (area under curve = 0.719 ± 0.036, p < 0.001) found. identified 0.033 mm demonstrated reliable specificity (77.6%) moderate sensitivity (59.1%). Cross-validation confirmed value's association TFOS II criterion (Cramer's V 0.354, 0.006). (4) Conclusions: provides evidence identifying ADDE. enhances offers sensitivity, providing an objective tool clinical decision making.
Язык: Английский
Процитировано
4
Vision, Год журнала: 2024, Номер 8(1), С. 8 - 8
Опубликована: Фев. 26, 2024
Background: The prevalence of dry eye disease (DED) is increasing globally, resulting in a variety symptoms characterized by discomfort and visual disturbances. accurate diagnosis the often challenging complex, requiring specialized diagnostic tools. This study aimed to investigate impact tear film instability on function evaluate value post-blink blur time (PBBT) as an alternative method for assessing stability. Methods: included 62 subjects: 31 with subjective DED (Group A) control group consisting healthy participants B). Symptoms were assessed using standard Schein questionnaire, supplemented additional questions. PBBT was measured Snellen charts potential association between dysfunction. Additional clinical assessments break-up (TBUT). Results: Statistically significant differences observed average values TBUT examined groups. 8.95 ± 5.38 s 14.66 10.50 group, p < 0.001. Group A exhibited 4.77 2.37 s, while B had 7.63 3.25 Additionally, strong positive correlation identified (r = 0.455; 0.001). Conclusions: research confirms that stability has important role refraction light maintenance optical quality vision. could potentially objective clinically screening test DED.
Язык: Английский
Процитировано
4
Journal of Clinical Medicine, Год журнала: 2025, Номер 14(2), С. 623 - 623
Опубликована: Янв. 19, 2025
Background: The aim of the present study was to establish a cut-off value Lipid Layer Pattern (LLP) between participants with different subtypes Dry Eye Disease (DED) including Deficient (ADDE), Evaporative (EDE), and Mixed (MDE). Methods: 240 diagnosed DED according Tear Film Ocular Surface Society in Workshop II guidelines were included study. Meniscus Height (TMH) using Tearscope illumination Meibomian Gland Loss Area (MGLA) Keratograph 5M assessed categorize into an ADDE group, EDE or MDE group. Then, LLP following Guillon (LLP-G) Colour (LLP-C) schemes. Results: Receiver Operating Characteristics (ROC) showed that both LLP-G LLP-C have no diagnostic potential distinguishing (both p ≥ 0.724). However, differentiate from MDE, ROC procedures good values Closed Meshwork-Wave (AUC ± SD = 0.609 0.049, 0.038, sensitivity: 23.9%; specificity: 76.1%) Grey-White 0.611 0.050, 0.034, 40.7%; 73.9%) for LLP-C, respectively. Also, significant distinguish found, Meshwork 0.604 0.043, 40.8%; 0.051, 44.7%; Conclusions: Using Tearscope, has other DED.
Язык: Английский
Процитировано
0
Journal of Clinical Medicine, Год журнала: 2023, Номер 12(23), С. 7484 - 7484
Опубликована: Дек. 4, 2023
Dry eye disease (DED) is a common chronic condition with increasing prevalence. Standard discriminative visual acuity not reflective of real-world function, as patients can achieve normal acuities by blinking. Participants recruited from tertiary referral centre were divided into two groups-Severe DED (with significant, central staining) and Mild (absence such staining). Functional Visual Acuity (FVA) in both groups was assessed using the DryeyeKT mobile application Impact Vision Impairment (IVI) questionnaire to assess quality life (QOL). Among 78 participants (74.4% women), 30 (38.5%) had Severe 48 (61.5%) DED. In women, produced significantly worse FVA 0.53 ± 0.20 vs. 0.73 0.30 group (p = 0.006). decreased age, showing significant inverse correlation (r -0.55). A poorer ≤ 0.6 seen older (68.2 years 7.68) an > younger (58.9 10.7), p < 0.001. When adjusting for still 0.107 lower group, 0.003. There difficulty performing specific daily activities after gender FVA. reduced severe people. impacts certain aspects QOL. However, no relationship found between only reason compromise health-related QOL dry eye.
Язык: Английский
Процитировано
10
Photonics, Год журнала: 2024, Номер 11(2), С. 165 - 165
Опубликована: Фев. 8, 2024
Myopia is a refractive error widely spread throughout the world, usually related to excessive axial length (AL) of eye. This elongation could have severe consequences, even leading blindness. However, AL varies among subjects, and it may be correlated with other anthropometric parameters. The aim this study was evaluate relationships between AL, body height, error, sex. A total 72 eyes 36 myopic participants mean age 11.1 ± 1.42 years (ranging from 8 14 years) were included in study. Participants underwent objective refraction by NVision-K5001, measurement Topcon MYAH biometer, height measurement. Significant correlations observed spherical equivalent (SE) (Spearman’s correlation, all p ≤ 0.016). When grouped significant differences for SE, when percentile, SE (Kruskal–Wallis test, 0.006). There difference genders (Mann–Whitney U 0.038). relates state eye also influenced individual anatomical characteristics.
Язык: Английский
Процитировано
3
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(14), С. 11273 - 11273
Опубликована: Июль 10, 2023
Ocular surface diseases (OSDs) are significant causes of ocular morbidity, and often associated with chronic inflammation, redness, irritation, discomfort, pain. In severe OSDs, loss vision can result from failure, characterised by limbal stem cell deficiencies, corneal vascularisation, opacification, keratinisation. External internal exposomes measures environmental factors that individuals exposed to, have been increasingly studied for their impact on diseases. consist external such as dust, pollution, stress; the microbiome, gut microflora, oxidative stress. Concerning exposomes, alterations in commensal microbiome patients OSDs reported due to advancements metagenomics using next-generation sequencing. Changes may be a consequence underlying disease processes or role pathogenesis OSDs. Understanding changes various other also help establish causative inflammation scarring, hallmarks This review provides summary current evidence
Язык: Английский
Процитировано
7
Journal of Clinical Medicine, Год журнала: 2024, Номер 13(6), С. 1618 - 1618
Опубликована: Март 12, 2024
Background: To evaluate the effects of 10% GlicoPro tear substitute therapy in patients with severe dry eye disease (DED). Methods: In this prospective longitudinal study, 30 individuals receiving four times daily for DED were evaluated. The ocular surface index (OSDI) questionnaire, average non-invasive break-up time (A-NIBUT), non-anesthetic and anesthetic corneal esthesiometry (CE), pain, presence conjunctivochalasis (CCH) used as clinical endpoints. Treatment compliance using dosing diaries AEs was assessed. Results: A significant improvement observed endpoints: ΔOSDI questionnaire −39.27 ± 13.22 [−65 to −15] points, ΔA-NIBUT 3.10 1.31 [1 5] s, Δnon-anesthetic CE 14 6.35 [5 25] mm, Δanesthetic 13 5.35 20] mm (p < 0.001 all comparisons). Ocular pain reduced 92.5% at end follow-up. However, there no change CCH. addition, fully compliant related use reported. Conclusions: has potential achieve beneficial treatments.
Язык: Английский
Процитировано
2
Journal of Clinical Medicine, Год журнала: 2023, Номер 12(9), С. 3203 - 3203
Опубликована: Апрель 29, 2023
Autoimmune thyroid diseases (ATDs) are potentially connected to lacrimal gland dysfunction and ocular surface disruption. This study aimed evaluate the relationships between ATD, dry eye disease (DED), corneal damage. In a matched nationwide cohort study, we used Taiwan's National Health Insurance research database compare incidences of DED damage subjects with without ATD. Multivariable Cox proportional hazards regression models were estimate adjusted hazard ratio (aHR) 95% confidence interval (CI) for ophthalmological outcomes. A total 50,251 pairs 748,961 person-years follow-up included analysis. The incidence was 16.37 8.36 per 1000 in ATD non-ATD groups, respectively. ATDs significantly associated increased (aHR: 1.81, CI: 1.73-1.89, p < 0.0001). association generally consistent across subgroups age, sex, different comorbidity levels, use systemic corticosteroids or not. Furthermore, patients had higher risk compared 1.31, 1.19-1.44, 0.0001), including recurrent erosions 2.00, 1.66-2.41, 0.0001) scars 1.26, 1.01-1.59, = 0.0432). Other independent factors diabetes mellitus, Charlson Comorbidity Index scores, corticosteroids. Our results suggested that risks Considering high prevalence prophylactic therapeutic strategies should be further developed prevent irreversible vision loss this susceptible population.
Язык: Английский
Процитировано
4
Diagnostics, Год журнала: 2024, Номер 14(6), С. 586 - 586
Опубликована: Март 10, 2024
This study aimed to evaluate the potential association between coronary heart disease (CHD) severity and subsequent dry eye (DED) with a different through use of National Health Insurance Research Database (NHIRD) Taiwan. A retrospective cohort was conducted. The CHD population further divided into severe that had received artery bypass graft (CABG) surgery group mild medicine group, then matched 1:2 ratio, 29,852 14,926 patients were put groups, respectively. primary outcomes development DED after diagnosis. Cox proportional hazards regression used produce adjusted hazard ratio (aHR) 95% confidence interval (CI) groups. There 3440 1276 cases in And another 37 48 events observed incidence significantly higher compared (aHR: 5.454, CI: 1.551–7.180, p = 0.0001). cumulative probabilities than (both < In subgroup analysis, correlation aged older 70 years (p conclusion, is associated incidence.
Язык: Английский
Процитировано
1
Photonics, Год журнала: 2024, Номер 11(4), С. 377 - 377
Опубликована: Апрель 17, 2024
The present study aimed to assess the agreement of three commercially available devices on measurement anterior chamber depth (ACD) with and without compensation by central corneal thickness (CCT). Fifty eyes were included in an observational cross-sectional study. Participants underwent a single visit during which used obtain inclusion/exclusion (ARK510A, Canon TX-10) studied (VX-120, Lenstar LS900 EchoScan US-800) parameters. Based invasiveness, tests always performed same order one researcher (to avoid inter-observer variability) only right eye overstating precision estimates) each participant. keratometry, autorefraction, intraocular pressure angle values as inclusion criteria, while CCT ACD analysis between devices. There was general paired difference measurements (Greenhouse–Geisser: p ≤ 0.001; Sidak: all 0.001). No significant found compensated = 0.200). Pairwise showed VX-120 vs. (Sidak: 0.021). differences clinically acceptable. Consequently, using these instruments interchangeably daily routines based this correction is justified.
Язык: Английский
Процитировано
1