Application and Progression of Single‐Cell RNA Sequencing in Diabetes Mellitus and Diabetes Complications

Journal of Diabetes Research, Год журнала: 2025, Номер 2025(1)

Опубликована: Янв. 1, 2025

Diabetes is a systemic metabolic disorder primarily caused by insulin deficiency and resistance, leading to chronic hyperglycemia. Prolonged diabetes can result in damage multiple organs, including the heart, brain, liver, muscles, adipose tissue, thereby causing various fatal complications such as diabetic retinopathy, cardiomyopathy, nephropathy. Single‐cell RNA sequencing (scRNA‐seq) has emerged valuable tool for investigating cell diversity pathogenesis of identifying potential therapeutic targets or complications. This review provides comprehensive overview recent applications scRNA‐seq diabetes‐related researches highlights novel biomarkers immunotherapy with cell‐type information its associated

Язык: Английский

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The potential therapeutic role of IL-35 in pathophysiological processes in type 1 diabetes mellitus

Cytokine, Год журнала: 2024, Номер 182, С. 156732 - 156732

Опубликована: Авг. 9, 2024

Язык: Английский

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Physiological and pathogenic T cell autoreactivity converge in type 1 diabetes

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Окт. 29, 2024

Язык: Английский

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Type 1 diabetes: immune pathology and novel therapeutic approaches

Diabetology International, Год журнала: 2024, Номер 15(4), С. 761 - 776

Опубликована: Сен. 11, 2024

Язык: Английский

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Comment on Narsale et al. Th2 cell clonal expansion at diagnosis in human type 1 diabetes. Clin Immunol. 2023 Oct 29

Clinical Immunology, Год журнала: 2023, Номер 258, С. 109873 - 109873

Опубликована: Дек. 19, 2023

Язык: Английский

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