Manual Therapy Improves Fibromyalgia Symptoms by Downregulating SIK1 DOI Open Access
Javier Bonastre-Férez, Karen Giménez-Orenga, Francisco Javier Falaguera-Vera

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(17), С. 9523 - 9523

Опубликована: Сен. 1, 2024

Fibromyalgia (FM), classified by ICD-11 with code MG30.0, is a chronic debilitating disease characterized widespread pain, fatigue, cognitive impairment, sleep, and intestinal alterations, among others. FM affects large proportion of the worldwide population, increased prevalence women. The lack understanding its etiology pathophysiology hampers development effective treatments. Our group had developed manual therapy (MT) pressure-controlled custom protocol on showing hyperalgesia/allodynia, patient’s quality life benefits in cohort 38 cases (NCT04174300). With aim therapeutic molecular mechanisms triggered MT, this study interrogated Peripheral Blood Mononuclear Cell (PBMC) transcriptomes from participants clinical trial using whole RNA sequencing (RNAseq) reverse transcription followed quantitative Polymerase Chain Reaction (RT-qPCR) technologies. results show that salt-induced kinase SIK1 gene was consistently downregulated MT FM, correlating improvement patient symptoms. In addition, compared findings non-FM control subjected to same protocol, evidencing those changes expression only occurred individuals FM. This positions as potential biomarker monitor response target which will be further explored continuation studies.

Язык: Английский

The PACE Trial’s GET Manual for Therapists Exposes the Fixed Incremental Nature of Graded Exercise Therapy for ME/CFS DOI Creative Commons
Mark Vink,

Katarzyna Partyka-Vink

Life, Год журнала: 2025, Номер 15(4), С. 584 - 584

Опубликована: Апрель 2, 2025

The British National Institute for Health and Care Excellence (NICE) published its updated guidelines myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) in October 2021. NICE concluded, after an extensive review of the literature, that graded exercise therapy (GET) is harmful should not be used, cognitive behavioural (CBT) only adjunctive a curative treatment. An article by White et al., which written 51 researchers, claims there are eight anomalies process interpretation evidence NICE. In this article, we reviewed they used to support their claims. Their three most important redefined disease, CBT GET effective, fixed incremental increases part GET. However, our analysis shows disease was Instead, it 1990s group doctors, including number authors when erased main characteristic (an abnormally delayed muscle recovery trivial exertion, which, over years, has evolved into post-exertional malaise) replaced with chronic disabling severe fatigue. own studies show do lead substantial improvement quality-of-life scores or reduction CFS symptom count, nor objective improvement. Also, both treatments have negative instead positive effect on work disability status. Moreover, recent systematic review, included one showed ME/CFS patients remain severely disabled treatment CBT. Our of, example, PACE trial’s manual therapists exposes nature Why aware unclear because them were involved trial. Three centre leaders principal investigators, four others also leaders, another independent safety assessors many these wrote, writing, manual. conclusion, arguments claim anomalous highlight absence made. Furthermore, GET, but ME/CFS.

Язык: Английский

Процитировано

0
Clinical Characterization of New-Onset Chronic Musculoskeletal Pain in Long COVID: A Cross-Sectional Study DOI Creative Commons
Omar Khoja, Bárbara Silva-Passadouro, E Cristescu

и другие.

Journal of Pain Research, Год журнала: 2024, Номер Volume 17, С. 2531 - 2550

Опубликована: Июль 1, 2024

New-onset chronic musculoskeletal (MSK) pain is one of the common persistent symptoms in Long COVID (LC). This study investigated its clinical characteristics, underlying mechanisms, and impact on function, psychological health, quality life.

Язык: Английский

Процитировано

2
New-Onset Chronic Musculoskeletal Pain Following COVID-19 Infection Fulfils the Fibromyalgia Clinical Syndrome Criteria: A Preliminary Study DOI Creative Commons
Omar Khoja, Matthew R Mulvey, Sarah Astill

и другие.

Biomedicines, Год журнала: 2024, Номер 12(9), С. 1940 - 1940

Опубликована: Авг. 23, 2024

New-onset chronic musculoskeletal (MSK) pain (>3 months duration) is a common symptom of post-COVID-19 syndrome (PCS). This study aimed to characterise new-onset MSK in patients with PCS and its overlap Fibromyalgia Syndrome (FMS). We enrolled assessed the nature associated symptoms using C19-YRS (Yorkshire Rehabilitation Scale). The FMS assessment was conducted as part standard clinical examination American College Rheumatology (ACR) 2010 criteria: (1) Widespread Pain Index (WPI) ≥ 7 severity (SS) score 5, or WPI between 3 6 SS 9, (2) consistent for at least months, (3) no alternative diagnosis. Of eighteen (average age 49.6 (SD 11.8) years; BMI 31.7 8.6)), twelve were female. average duration 27.9 6.97) post-infection. Thirteen (72.2%) met criteria, an 8.8 8.2, indicating high level significant quality life impacts. These findings support hypothesis that may develop long-term sequela viral infection, underscoring need further research into post-viral conditions.

Язык: Английский

Процитировано

2
New-onset chronic musculoskeletal pain following COVID-19 infection fulfil the Fibromyalgia clinical syndrome criteria DOI
Omar Khoja, Matthew R Mulvey, Sarah Astill

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июль 11, 2024

ABSTRACT Background New-onset chronic musculoskeletal (MSK) pain (> 3 months duration) is one of the commonest persistent symptoms Post-COVID syndrome (PCS). There emerging evidence that MSK and associated in PCS have similarities to Fibromyalgia Syndrome (FMS). This study aimed characterise related new-onset its overlap with Methods Patients following COVID-19 infection were enrolled nature captured using C19-YRS (Yorkshire Rehabilitation Scale). FMS assessment was conducted as part standard clinical examination American College Rheumatology (ACR) 2010 criteria. Diagnosis made when they meet criteria (1) Widespread Pain Index (WPI) ≥ 7 Symptoms Severity (SS) score 5, or WPI 3-6 SS 9, (2) been present at a similar level for least months, (3) patient does not disorder would otherwise explain symptoms. Results Eighteen patients, twelve whom female, an average age 49.6 (SD 11.8) years Body Mass 31.7 8.6) enrolled. The duration from 27.9 6.97) months. widespread, primarily manifesting muscle pain. Thirteen (72.2%) patients met diagnostic FMS, 8.8 8.2, indicating high significant adverse impact on their quality life. Conclusion found 72.2% FMS. These findings support hypothesis may develop long-term sequela viral infection, underscoring need further research into post-viral conditions.

Язык: Английский

Процитировано

1
Manual Therapy Improves Fibromyalgia Symptoms by Downregulating SIK1 DOI Open Access
Javier Bonastre-Férez, Karen Giménez-Orenga, Francisco Javier Falaguera-Vera

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(17), С. 9523 - 9523

Опубликована: Сен. 1, 2024

Fibromyalgia (FM), classified by ICD-11 with code MG30.0, is a chronic debilitating disease characterized widespread pain, fatigue, cognitive impairment, sleep, and intestinal alterations, among others. FM affects large proportion of the worldwide population, increased prevalence women. The lack understanding its etiology pathophysiology hampers development effective treatments. Our group had developed manual therapy (MT) pressure-controlled custom protocol on showing hyperalgesia/allodynia, patient’s quality life benefits in cohort 38 cases (NCT04174300). With aim therapeutic molecular mechanisms triggered MT, this study interrogated Peripheral Blood Mononuclear Cell (PBMC) transcriptomes from participants clinical trial using whole RNA sequencing (RNAseq) reverse transcription followed quantitative Polymerase Chain Reaction (RT-qPCR) technologies. results show that salt-induced kinase SIK1 gene was consistently downregulated MT FM, correlating improvement patient symptoms. In addition, compared findings non-FM control subjected to same protocol, evidencing those changes expression only occurred individuals FM. This positions as potential biomarker monitor response target which will be further explored continuation studies.

Язык: Английский

Процитировано

0