Gut Microbiota and Their Metabolites: The Hidden Driver of Diabetic Nephropathy? Unveiling Gut Microbe's Role in DN
Journal of Diabetes,
Год журнала:
2025,
Номер
17(4)
Опубликована: Апрель 1, 2025
ABSTRACT
Background
Diabetic
nephropathy
(DN)
is
a
severe
microvascular
complication
of
diabetes
with
complex
pathogenesis.
Methods
Recent
studies
were
reviewed
to
explore
the
role
gut
microbiota
and
its
metabolites
in
DN
development.
Results
Dysbiosis
bacteria
contributes
pathological
changes
such
as
glomerular
sclerosis
renal
tubule
injury.
Microbial
are
involved
through
immune
inflammatory
pathways.
Conclusions
Understanding
relationship
between
microbiota,
metabolites,
may
offer
potential
implications
for
diagnosis,
prevention,
treatment.
Translating
this
knowledge
into
clinical
practice
presents
challenges
opportunities.
Язык: Английский
SUSTAINABLE FOOD SYSTEMS: FUNCTIONAL FOODS AND MANAGEMENT OF FOOD WASTE
GIDA / THE JOURNAL OF FOOD,
Год журнала:
2025,
Номер
50(3), С. 415 - 426
Опубликована: Май 12, 2025
The
increasing
global
population,
changing
consumption
patterns
and
climate
change
are
putting
significant
pressure
on
food
systems.
There
is
a
strong
focus
the
development
of
sustainable
systems
that
prioritize
efficient
use
resources,
reduce
environmental
impacts,
ensure
everyone
has
access
to
healthy
nutritious
food.
Functional
foods
known
for
their
high
nutritional
values
beneficial
bioactive
components
positively
affect
human
health.
Additionally,
they
have
potential
help
waste.
This
review
examines
relationship
between
functional
nutrition
impacts
waste
in
this
context
by
referencing
current
academic
literature.
Also,
detailed
examination
upcycled
revalue
attribute
economic
value
according
circular
economy
principles
were
given.
It
expected
reducing
will
provide
benefits
environment,
economy,
health
through
inclusion
practices
foods.
Язык: Английский
The Effect of Microbiome-Modulating Agents (MMAs) on Type 1 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Nutrients,
Год журнала:
2024,
Номер
16(11), С. 1675 - 1675
Опубликована: Май 29, 2024
Gut
microbiome-modulating
agents
(MMAs),
including
probiotics,
prebiotics,
postbiotics,
and
synbiotics,
are
shown
to
ameliorate
type
1
diabetes
(T1D)
by
restoring
the
microbiome
from
dysbiosis.
The
objective
of
this
systematic
review
meta-analysis
was
assess
impact
MMAs
on
hemoglobin
A1c
(HbA1c)
biomarkers
associated
with
(T1D).
A
comprehensive
search
conducted
in
PubMed,
Web
Science,
Embase,
Cochrane
Library,
National
Knowledge
Infrastructure,
WeiPu,
WanFang
Data
up
30
November
2023.
Ten
randomized
controlled
trials
(n
=
630)
were
included,
study
quality
evaluated
using
risk-of-bias
tool.
Random-effect
models
standardized
mean
differences
(SMDs)
utilized.
MMA
supplementation
improvements
HbA1c
(SMD
−0.52,
95%
CI
[−0.83,
−0.20]),
daily
insulin
usage
−0.41,
confidence
interval
(CI)
[−0.76,
−0.07]),
fasting
C-peptide
0.99,
[0.17,
1.81])
but
had
no
effects
FBG,
CRP,
TNF-α,
IL-10,
LDL,
HDL,
Shannon
index.
Subgroup
analysis
indicated
that
a
long-term
intervention
(>3
months)
might
exert
more
substantial
effect.
These
findings
suggest
an
association
between
glycemic
control
T1D.
Further
large-scale
clinical
necessary
confirm
these
investigations
inflammation
gut
microbiota
composition
while
adjusting
confounding
factors
such
as
diet,
physical
activity,
dose
form
intervention.
Язык: Английский
Probiotics intervention for type 2 diabetes mellitus therapy: a review from proposed mechanisms to future prospects
Critical Reviews in Food Science and Nutrition,
Год журнала:
2024,
Номер
unknown, С. 1 - 19
Опубликована: Авг. 8, 2024
Type
2
diabetes
mellitus
(T2DM)
is
one
of
the
metabolic
diseases
with
highest
morbidity
rates
in
world.
Probiotics
have
positive
health
impacts
on
human
and
a
considerable
amount
research
has
demonstrated
their
beneficial
effects
treating
T2DM.
However,
probiotic
intervention
T2DM
complex
mechanisms
because
pathogenesis
complex.
This
review
summarized
from
perspective
pathogenesis.
First,
objectives
aimed
at
intestinal
tract
reparative
effects,
pancreatic
function,
host
metabolism
self-recovery
were
comprehensively
reviewed.
Next,
we
concluded
clinical
application
status
ingested
probiotics
patients
T2DM,
an
obvious
imbalance
exists
between
theoretical
applications.
Finally,
emerging
interventions
analyzed
literature
this
regard,
including
next-generation
probiotics;
suggestions
for
consumption
aim
diabetic
complications;
as
well
association
novel
remission
potential
intervention.
In
conclusion,
sheds
light
role
probiotics,
proposed
to
prospects
relieving
Язык: Английский
Impact of Probiotics on the Glycemic Control of Pediatric and Adolescent Individuals with Type 1 Diabetes: A Systematic Review and Meta-Analysis
Nutrients,
Год журнала:
2024,
Номер
16(16), С. 2629 - 2629
Опубликована: Авг. 9, 2024
Aims:
Human
recombinant
insulin
is
currently
the
only
therapy
for
children
and
adolescents
with
type
1
diabetes
(T1D),
although
not
always
efficient
glycemic
control
of
these
individuals.
The
interrelation
between
gut
microbiome
apparently
healthy
populations,
as
well
various
populations
diabetes,
undeniable.
Probiotics
are
biotherapeutics
that
deliver
active
components
to
targets,
primarily
gastrointestinal
tract.
This
systematic
review
meta-analysis
examined
effect
administration
probiotics
on
pediatric
adolescent
individuals
T1D.
Materials
Methods:
Randomized
controlled
trials
employing
in
T1D
(with
≥10
per
treatment
arm),
written
English,
providing
parameters
control,
such
mean
glucose
concentrations
glycosylated
hemoglobin
(HbA1c),
were
deemed
eligible.
Results:
search
strategy
resulted
six
papers
contradictory
findings.
Ultimately,
five
studies
acceptable
quality,
comprising
388
T1D,
included
meta-analysis.
Employing
a
random
fixed
effects
model
revealed
statistically
significant
negative
sizes
those
individuals,
i.e.,
higher
HbA1c
than
controls.
Conclusions:
Children
who
received
demonstrated
worse
controls
after
intervention.
Adequately
powered
studies,
extended
follow-up
periods,
along
monitoring
compliance
proper
strains,
required
unravel
mechanisms
action
relative
probiotics,
particularly
concerning
diabetes-related
complications
metabolic
outcomes.
Язык: Английский
Optimizing the Health of Type 2 Diabetes Mellitus Patients with Islamic Approaches and Volunteers
Qubahan Academic Journal,
Год журнала:
2024,
Номер
4(2)
Опубликована: Май 20, 2024
Depression,
which
is
prevalent
in
patients
with
diabetes
mellitus,
can
be
addressed
by
integrating
Islamic
mindfulness
practices
and
family
volunteer
support.
This
study
assessed
the
impact
of
combining
practice
(IMP)
support
on
depressive
symptoms
knowledge
type
2
mellitus
(T2DM).
A
total
120
Muslim
diagnosed
T2DM
having
a
Beck's
Depression
Inventory
(BDI)
score
>17
participated.
The
intervention
group
engaged
facilitated
discussions
led
volunteers,
focusing
techniques
education.
results
underscored
importance
combined
awareness
for
depression,
showing
reduced
as
measured
BDI
after
intervention.
In
addition,
showed
improved
chronic
condition
based
Diabetes
Knowledge
Questionnaire
(DKQ)
data
compared
to
control
group.
conclusion,
caring
depression
reduce
improve
knowledge.
Язык: Английский
Can an intensive food-as-medicine programme enhance preventive care engagement without improving glycaemic control in patients with T2DM?
Evidence-Based Nursing,
Год журнала:
2024,
Номер
unknown, С. ebnurs - 104016
Опубликована: Июль 13, 2024
Язык: Английский
Unravelling the Role of Gut and Oral Microbiota in the Pediatric Population with Type 1 Diabetes Mellitus
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(19), С. 10611 - 10611
Опубликована: Окт. 2, 2024
Type
1
Diabetes
Mellitus
(T1DM)
is
a
chronic
autoimmune
disease
that
results
in
the
destruction
of
pancreatic
β
cells,
leading
to
hyperglycaemia
and
need
for
lifelong
insulin
therapy.
Although
genetic
predisposition
environmental
factors
are
considered
key
contributors
T1DM,
exact
causes
remain
partially
unclear.
Recent
evidence
has
focused
on
relationship
between
gut,
oral
cavity,
immune
regulation,
systemic
inflammation.
In
individuals
with
changes
gut
microbial
composition
commonly
observed,
indicating
dysbiosis
may
contribute
dysregulation.
Gut
can
influence
system
through
increased
intestinal
permeability,
altered
production
short
chain
fatty
acids
(SCFAs),
interactions
mucosal
system,
potentially
triggering
response.
Similarly,
development
inflammation
thus
progression
T1DM.
A
comprehensive
understanding
these
relationships
essential
identification
biomarkers
early
diagnosis
monitoring,
as
well
therapies
aimed
at
restoring
balance.
This
review
presents
synthesis
current
research
connection
T1DM
microbiome
dysbiosis,
focus
microbiomes
pediatric
populations.
It
explores
potential
mechanisms
by
which
contributes
pathogenesis
examines
microbiome-based
therapies,
including
probiotics,
prebiotics,
synbiotics,
faecal
microbiota
transplantation
(FMT).
complex
highlights
longitudinal
studies
monitor
over
time,
investigate
causal
specific
species
develop
personalised
medicine
approaches.
Язык: Английский
Engineering Probiotics for Diabetes Management: Advances, Challenges, and Future Directions in Translational Microbiology
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 10917 - 10940
Опубликована: Окт. 1, 2024
Diabetes
Mellitus
(DM)
is
a
substantial
health
concern
worldwide,
and
its
incidence
progressively
escalating.
Conventional
pharmacological
interventions
frequently
entail
undesirable
side
effects,
while
probiotics
offer
benefits,
they
are
hindered
by
constraints
such
as
diminished
stability
effectiveness
within
the
gastrointestinal
milieu.
Given
these
complications,
advent
of
bioengineered
promising
alternative
for
DM
management.
Язык: Английский