Gut Microbiota and Their Metabolites: The Hidden Driver of Diabetic Nephropathy? Unveiling Gut Microbe's Role in DN

Journal of Diabetes, Journal Year: 2025, Volume and Issue: 17(4)

Published: April 1, 2025

ABSTRACT Background Diabetic nephropathy (DN) is a severe microvascular complication of diabetes with complex pathogenesis. Methods Recent studies were reviewed to explore the role gut microbiota and its metabolites in DN development. Results Dysbiosis bacteria contributes pathological changes such as glomerular sclerosis renal tubule injury. Microbial are involved through immune inflammatory pathways. Conclusions Understanding relationship between microbiota, metabolites, may offer potential implications for diagnosis, prevention, treatment. Translating this knowledge into clinical practice presents challenges opportunities.

Language: Английский

---

SUSTAINABLE FOOD SYSTEMS: FUNCTIONAL FOODS AND MANAGEMENT OF FOOD WASTE

GIDA / THE JOURNAL OF FOOD, Journal Year: 2025, Volume and Issue: 50(3), P. 415 - 426

Published: May 12, 2025

The increasing global population, changing consumption patterns and climate change are putting significant pressure on food systems. There is a strong focus the development of sustainable systems that prioritize efficient use resources, reduce environmental impacts, ensure everyone has access to healthy nutritious food. Functional foods known for their high nutritional values beneficial bioactive components positively affect human health. Additionally, they have potential help waste. This review examines relationship between functional nutrition impacts waste in this context by referencing current academic literature. Also, detailed examination upcycled revalue attribute economic value according circular economy principles were given. It expected reducing will provide benefits environment, economy, health through inclusion practices foods.

Language: Английский

---

The Effect of Microbiome-Modulating Agents (MMAs) on Type 1 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Nutrients, Journal Year: 2024, Volume and Issue: 16(11), P. 1675 - 1675

Published: May 29, 2024

Gut microbiome-modulating agents (MMAs), including probiotics, prebiotics, postbiotics, and synbiotics, are shown to ameliorate type 1 diabetes (T1D) by restoring the microbiome from dysbiosis. The objective of this systematic review meta-analysis was assess impact MMAs on hemoglobin A1c (HbA1c) biomarkers associated with (T1D). A comprehensive search conducted in PubMed, Web Science, Embase, Cochrane Library, National Knowledge Infrastructure, WeiPu, WanFang Data up 30 November 2023. Ten randomized controlled trials (n = 630) were included, study quality evaluated using risk-of-bias tool. Random-effect models standardized mean differences (SMDs) utilized. MMA supplementation improvements HbA1c (SMD −0.52, 95% CI [−0.83, −0.20]), daily insulin usage −0.41, confidence interval (CI) [−0.76, −0.07]), fasting C-peptide 0.99, [0.17, 1.81]) but had no effects FBG, CRP, TNF-α, IL-10, LDL, HDL, Shannon index. Subgroup analysis indicated that a long-term intervention (>3 months) might exert more substantial effect. These findings suggest an association between glycemic control T1D. Further large-scale clinical necessary confirm these investigations inflammation gut microbiota composition while adjusting confounding factors such as diet, physical activity, dose form intervention.

Language: Английский

---

Probiotics intervention for type 2 diabetes mellitus therapy: a review from proposed mechanisms to future prospects

Critical Reviews in Food Science and Nutrition, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 19

Published: Aug. 8, 2024

Type 2 diabetes mellitus (T2DM) is one of the metabolic diseases with highest morbidity rates in world. Probiotics have positive health impacts on human and a considerable amount research has demonstrated their beneficial effects treating T2DM. However, probiotic intervention T2DM complex mechanisms because pathogenesis complex. This review summarized from perspective pathogenesis. First, objectives aimed at intestinal tract reparative effects, pancreatic function, host metabolism self-recovery were comprehensively reviewed. Next, we concluded clinical application status ingested probiotics patients T2DM, an obvious imbalance exists between theoretical applications. Finally, emerging interventions analyzed literature this regard, including next-generation probiotics; suggestions for consumption aim diabetic complications; as well association novel remission potential intervention. In conclusion, sheds light role probiotics, proposed to prospects relieving

Language: Английский

---

Impact of Probiotics on the Glycemic Control of Pediatric and Adolescent Individuals with Type 1 Diabetes: A Systematic Review and Meta-Analysis

Nutrients, Journal Year: 2024, Volume and Issue: 16(16), P. 2629 - 2629

Published: Aug. 9, 2024

Aims: Human recombinant insulin is currently the only therapy for children and adolescents with type 1 diabetes (T1D), although not always efficient glycemic control of these individuals. The interrelation between gut microbiome apparently healthy populations, as well various populations diabetes, undeniable. Probiotics are biotherapeutics that deliver active components to targets, primarily gastrointestinal tract. This systematic review meta-analysis examined effect administration probiotics on pediatric adolescent individuals T1D. Materials Methods: Randomized controlled trials employing in T1D (with ≥10 per treatment arm), written English, providing parameters control, such mean glucose concentrations glycosylated hemoglobin (HbA1c), were deemed eligible. Results: search strategy resulted six papers contradictory findings. Ultimately, five studies acceptable quality, comprising 388 T1D, included meta-analysis. Employing a random fixed effects model revealed statistically significant negative sizes those individuals, i.e., higher HbA1c than controls. Conclusions: Children who received demonstrated worse controls after intervention. Adequately powered studies, extended follow-up periods, along monitoring compliance proper strains, required unravel mechanisms action relative probiotics, particularly concerning diabetes-related complications metabolic outcomes.

Language: Английский

---

Optimizing the Health of Type 2 Diabetes Mellitus Patients with Islamic Approaches and Volunteers

Qubahan Academic Journal, Journal Year: 2024, Volume and Issue: 4(2)

Published: May 20, 2024

Depression, which is prevalent in patients with diabetes mellitus, can be addressed by integrating Islamic mindfulness practices and family volunteer support. This study assessed the impact of combining practice (IMP) support on depressive symptoms knowledge type 2 mellitus (T2DM). A total 120 Muslim diagnosed T2DM having a Beck's Depression Inventory (BDI) score >17 participated. The intervention group engaged facilitated discussions led volunteers, focusing techniques education. results underscored importance combined awareness for depression, showing reduced as measured BDI after intervention. In addition, showed improved chronic condition based Diabetes Knowledge Questionnaire (DKQ) data compared to control group. conclusion, caring depression reduce improve knowledge.

Language: Английский

---

Can an intensive food-as-medicine programme enhance preventive care engagement without improving glycaemic control in patients with T2DM?

Evidence-Based Nursing, Journal Year: 2024, Volume and Issue: unknown, P. ebnurs - 104016

Published: July 13, 2024

Language: Английский

---

Unravelling the Role of Gut and Oral Microbiota in the Pediatric Population with Type 1 Diabetes Mellitus

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10611 - 10611

Published: Oct. 2, 2024

Type 1 Diabetes Mellitus (T1DM) is a chronic autoimmune disease that results in the destruction of pancreatic β cells, leading to hyperglycaemia and need for lifelong insulin therapy. Although genetic predisposition environmental factors are considered key contributors T1DM, exact causes remain partially unclear. Recent evidence has focused on relationship between gut, oral cavity, immune regulation, systemic inflammation. In individuals with changes gut microbial composition commonly observed, indicating dysbiosis may contribute dysregulation. Gut can influence system through increased intestinal permeability, altered production short chain fatty acids (SCFAs), interactions mucosal system, potentially triggering response. Similarly, development inflammation thus progression T1DM. A comprehensive understanding these relationships essential identification biomarkers early diagnosis monitoring, as well therapies aimed at restoring balance. This review presents synthesis current research connection T1DM microbiome dysbiosis, focus microbiomes pediatric populations. It explores potential mechanisms by which contributes pathogenesis examines microbiome-based therapies, including probiotics, prebiotics, synbiotics, faecal microbiota transplantation (FMT). complex highlights longitudinal studies monitor over time, investigate causal specific species develop personalised medicine approaches.

Language: Английский

---

Engineering Probiotics for Diabetes Management: Advances, Challenges, and Future Directions in Translational Microbiology

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 10917 - 10940

Published: Oct. 1, 2024

Diabetes Mellitus (DM) is a substantial health concern worldwide, and its incidence progressively escalating. Conventional pharmacological interventions frequently entail undesirable side effects, while probiotics offer benefits, they are hindered by constraints such as diminished stability effectiveness within the gastrointestinal milieu. Given these complications, advent of bioengineered promising alternative for DM management.

Language: Английский

---