Interoception and aging
Ageing Research Reviews,
Год журнала:
2025,
Номер
unknown, С. 102743 - 102743
Опубликована: Апрель 1, 2025
Язык: Английский
Alterations and mechanistic insights of gut microbiota and its metabolites in type 2 diabetes mellitus and Alzheimer's disease
iMetaOmics.,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 11, 2025
Abstract
Epidemiological
studies
suggest
a
link
between
type
2
diabetes
mellitus
(T2DM)
and
Alzheimer's
disease
(AD),
possibly
due
to
gut
microbiota
dysbiosis,
although
the
exact
mechanisms
are
unclear.
This
narrative
review
uniquely
addresses
how
microbiota‐derived
metabolites
mediate
overlapping
pathologies
of
insulin
resistance,
neuroinflammation,
amyloidogenesis
in
T2DM
AD,
proposing
framework
for
dual
therapeutic
targeting.
provides
an
in‐depth
examination
roles
their
context
AD.
study
indicates
that
dysbiosis
significantly
impacts
pathogenesis
progression
both
diseases
by
modulating
metabolic
pathways,
immune
functions,
inflammatory
responses.
Key
bacteria,
such
as
Akkermansia
muciniphila
(which
releases
outer
membrane
vesicles),
Lactobacillus
,
Bifidobacterium
well
like
short‐chain
fatty
acids
(SCFAs),
bile
(BAs),
lipopolysaccharide
(LPS),
vitamins,
Trimethylamine
N‐oxide
(TMAO)
regulate
AD
through
complex
mechanisms.
Multiple
signaling
including
G‐protein
coupled
receptor
41/43
(GPR41/43),
phosphoinositide
3‐kinase
(PI3K)/protein
kinase
B
(Akt),
Toll‐like
4
(TLR4)/nuclear
factor
kappa‐light‐chain‐enhancer
activated
cells
(NF‐κB),
endoplasmic
reticulum
(ER)
stress‐mediated
also
involved.
These
findings
offer
insights
into
potential
targeted
therapies
Язык: Английский
New insights into the pharmacological mechanisms of Jinqi Jiangtang Tablets in the treatment of type 2 diabetes mellitus: A multi-omics approach combined with experimental validation
Journal of Ethnopharmacology,
Год журнала:
2025,
Номер
unknown, С. 120020 - 120020
Опубликована: Май 1, 2025
Язык: Английский
The hypoglycemic effect of enzymatic modified dietary fiber from bamboo shoot on type 2 diabetes rats
Journal of Food Science,
Год журнала:
2024,
Номер
89(9), С. 5900 - 5911
Опубликована: Авг. 16, 2024
Abstract
Bamboo
shoot
is
a
healthy
food
rich
in
dietary
fiber
(DF).
However,
its
highly
insoluble
DF
and
fibrous
texture
limit
application
industrially
processed
foods.
To
achieve
industrial
processing
of
bamboo
shoot,
cellulase
was
used
to
improve
the
physical
characteristics
this
study.
After
enzymatic
hydrolysis,
content
soluble
(SDF)
increased
by
99.28%
(from
5.53%
11.02%)
significantly
(
p
<
0.01).
At
same
time,
effect
enzymatic‐modified
SDF
(EMBSDF)
on
streptozotocin‐induced
type
2
diabetes
rats
explored.
Results
demonstrated
that
high
dose
EMBSDF
(312.8
mg/kg)
treated
showed
significant
improvements
terms
glucose
tolerance
insulin
sensitivity
0.01)
compared
with
rats.
Meantime,
it
observed
levels
glucagon‐like
peptide‐1,
adiponectin
interleukin‐4
were
57.79%,
159.13%,
6.17%,
respectively.
The
tumor
necrosis
factor‐α,
C‐reactive
protein,
leptin
decreased
62.89%,
31.53%,
7.84%,
Furthermore,
apparent
kidney
pancreas
histology
found
high‐dose
mid‐dose
EMBSDF‐treated
These
results
indicated
modified
improved
diabetes.
Язык: Английский