The hypoglycemic effect of enzymatic modified dietary fiber from bamboo shoot on type 2 diabetes rats DOI

Xiangjie Yao,

Renkou Wan,

Chunxiao Li

et al.

Journal of Food Science, Journal Year: 2024, Volume and Issue: 89(9), P. 5900 - 5911

Published: Aug. 16, 2024

Abstract Bamboo shoot is a healthy food rich in dietary fiber (DF). However, its highly insoluble DF and fibrous texture limit application industrially processed foods. To achieve industrial processing of bamboo shoot, cellulase was used to improve the physical characteristics this study. After enzymatic hydrolysis, content soluble (SDF) increased by 99.28% (from 5.53% 11.02%) significantly ( p < 0.01). At same time, effect enzymatic‐modified SDF (EMBSDF) on streptozotocin‐induced type 2 diabetes rats explored. Results demonstrated that high dose EMBSDF (312.8 mg/kg) treated showed significant improvements terms glucose tolerance insulin sensitivity 0.01) compared with rats. Meantime, it observed levels glucagon‐like peptide‐1, adiponectin interleukin‐4 were 57.79%, 159.13%, 6.17%, respectively. The tumor necrosis factor‐α, C‐reactive protein, leptin decreased 62.89%, 31.53%, 7.84%, Furthermore, apparent kidney pancreas histology found high‐dose mid‐dose EMBSDF‐treated These results indicated modified improved diabetes.

Language: Английский

Interoception and aging DOI

Erliang Li,

Weihong Niu,

Chao Lu

et al.

Ageing Research Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102743 - 102743

Published: April 1, 2025

Language: Английский

Citations

0
Alterations and mechanistic insights of gut microbiota and its metabolites in type 2 diabetes mellitus and Alzheimer's disease DOI Creative Commons
Guangyi Xu, Yu An,

Yage Du

et al.

iMetaOmics., Journal Year: 2025, Volume and Issue: unknown

Published: May 11, 2025

Abstract Epidemiological studies suggest a link between type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD), possibly due to gut microbiota dysbiosis, although the exact mechanisms are unclear. This narrative review uniquely addresses how microbiota‐derived metabolites mediate overlapping pathologies of insulin resistance, neuroinflammation, amyloidogenesis in T2DM AD, proposing framework for dual therapeutic targeting. provides an in‐depth examination roles their context AD. study indicates that dysbiosis significantly impacts pathogenesis progression both diseases by modulating metabolic pathways, immune functions, inflammatory responses. Key bacteria, such as Akkermansia muciniphila (which releases outer membrane vesicles), Lactobacillus , Bifidobacterium well like short‐chain fatty acids (SCFAs), bile (BAs), lipopolysaccharide (LPS), vitamins, Trimethylamine N‐oxide (TMAO) regulate AD through complex mechanisms. Multiple signaling including G‐protein coupled receptor 41/43 (GPR41/43), phosphoinositide 3‐kinase (PI3K)/protein kinase B (Akt), Toll‐like 4 (TLR4)/nuclear factor kappa‐light‐chain‐enhancer activated cells (NF‐κB), endoplasmic reticulum (ER) stress‐mediated also involved. These findings offer insights into potential targeted therapies

Language: Английский

Citations

0
The hypoglycemic effect of enzymatic modified dietary fiber from bamboo shoot on type 2 diabetes rats DOI

Xiangjie Yao,

Renkou Wan,

Chunxiao Li

et al.

Journal of Food Science, Journal Year: 2024, Volume and Issue: 89(9), P. 5900 - 5911

Published: Aug. 16, 2024

Abstract Bamboo shoot is a healthy food rich in dietary fiber (DF). However, its highly insoluble DF and fibrous texture limit application industrially processed foods. To achieve industrial processing of bamboo shoot, cellulase was used to improve the physical characteristics this study. After enzymatic hydrolysis, content soluble (SDF) increased by 99.28% (from 5.53% 11.02%) significantly ( p < 0.01). At same time, effect enzymatic‐modified SDF (EMBSDF) on streptozotocin‐induced type 2 diabetes rats explored. Results demonstrated that high dose EMBSDF (312.8 mg/kg) treated showed significant improvements terms glucose tolerance insulin sensitivity 0.01) compared with rats. Meantime, it observed levels glucagon‐like peptide‐1, adiponectin interleukin‐4 were 57.79%, 159.13%, 6.17%, respectively. The tumor necrosis factor‐α, C‐reactive protein, leptin decreased 62.89%, 31.53%, 7.84%, Furthermore, apparent kidney pancreas histology found high‐dose mid‐dose EMBSDF‐treated These results indicated modified improved diabetes.

Language: Английский

Citations

1