Implications of altered NAD metabolism in metabolic disorders DOI Creative Commons
Keisuke Okabe, Keisuke Yaku, Kazuyuki Tobe

и другие.

Journal of Biomedical Science, Год журнала: 2019, Номер 26(1)

Опубликована: Май 11, 2019

Nicotinamide adenine dinucleotide (NAD) is an important coenzyme that participates in various energy metabolism pathways, including glycolysis, β-oxidation, and oxidative phosphorylation. Besides, it a required cofactor for post-translational modifications such as ADP-ribosylation deacetylation by poly (ADP-ribose) polymerases (PARPs) sirtuins, respectively. Thus, NAD regulates metabolism, DNA damage repair, gene expression, stress response through these enzymes. Numerous studies have shown levels decrease with aging under disturbed nutrient conditions, obesity. Additionally, decline closely related to the development of metabolic disorders, diabetes fatty liver disease. In addition, many revealed administration precursors, nicotinamide mononucleotide (NMN) riboside (NR), efficiently increase tissues prevent diseases. These precursors are contained natural foods, cow milk, vegetables, meats. Therefore, altered can be practical target nutritional intervention. Recently, several human clinical trials using been conducted investigate safety, pharmacokinetics, efficacy against disorders glucose intolerance. this review, we summarize current knowledge on implications diseases discuss outcomes recent trials.

Язык: Английский

Kynurenine pathway, NAD+ synthesis, and mitochondrial function: Targeting tryptophan metabolism to promote longevity and healthspan DOI
Raúl Castro-Portuguez, George L. Sutphin

Experimental Gerontology, Год журнала: 2020, Номер 132, С. 110841 - 110841

Опубликована: Янв. 16, 2020

Язык: Английский

Процитировано

205
Metabolic rearrangements in primary liver cancers: cause and consequences DOI

Letizia Satriano,

Monika Lewińska, Pedro M. Rodrigues

и другие.

Nature Reviews Gastroenterology & Hepatology, Год журнала: 2019, Номер 16(12), С. 748 - 766

Опубликована: Окт. 30, 2019

Язык: Английский

Процитировано

197
Mitochondrial dysfunction, oxidative stress, neuroinflammation, and metabolic alterations in the progression of Alzheimer’s disease: A meta-analysis of in vivo magnetic resonance spectroscopy studies DOI Creative Commons
Tao Song, Xiaopeng Song,

Chenyawen Zhu

и другие.

Ageing Research Reviews, Год журнала: 2021, Номер 72, С. 101503 - 101503

Опубликована: Окт. 29, 2021

Язык: Английский

Процитировано

190
Bacteria Boost Mammalian Host NAD Metabolism by Engaging the Deamidated Biosynthesis Pathway DOI
Igor Shats, Jason G. Williams,

Juan Liu

и другие.

Cell Metabolism, Год журнала: 2020, Номер 31(3), С. 564 - 579.e7

Опубликована: Март 1, 2020

Язык: Английский

Процитировано

175
Implications of altered NAD metabolism in metabolic disorders DOI Creative Commons
Keisuke Okabe, Keisuke Yaku, Kazuyuki Tobe

и другие.

Journal of Biomedical Science, Год журнала: 2019, Номер 26(1)

Опубликована: Май 11, 2019

Nicotinamide adenine dinucleotide (NAD) is an important coenzyme that participates in various energy metabolism pathways, including glycolysis, β-oxidation, and oxidative phosphorylation. Besides, it a required cofactor for post-translational modifications such as ADP-ribosylation deacetylation by poly (ADP-ribose) polymerases (PARPs) sirtuins, respectively. Thus, NAD regulates metabolism, DNA damage repair, gene expression, stress response through these enzymes. Numerous studies have shown levels decrease with aging under disturbed nutrient conditions, obesity. Additionally, decline closely related to the development of metabolic disorders, diabetes fatty liver disease. In addition, many revealed administration precursors, nicotinamide mononucleotide (NMN) riboside (NR), efficiently increase tissues prevent diseases. These precursors are contained natural foods, cow milk, vegetables, meats. Therefore, altered can be practical target nutritional intervention. Recently, several human clinical trials using been conducted investigate safety, pharmacokinetics, efficacy against disorders glucose intolerance. this review, we summarize current knowledge on implications diseases discuss outcomes recent trials.

Язык: Английский

Процитировано

173