Implications of altered NAD metabolism in metabolic disorders DOI Creative Commons
Keisuke Okabe, Keisuke Yaku, Kazuyuki Tobe

et al.

Journal of Biomedical Science, Journal Year: 2019, Volume and Issue: 26(1)

Published: May 11, 2019

Nicotinamide adenine dinucleotide (NAD) is an important coenzyme that participates in various energy metabolism pathways, including glycolysis, β-oxidation, and oxidative phosphorylation. Besides, it a required cofactor for post-translational modifications such as ADP-ribosylation deacetylation by poly (ADP-ribose) polymerases (PARPs) sirtuins, respectively. Thus, NAD regulates metabolism, DNA damage repair, gene expression, stress response through these enzymes. Numerous studies have shown levels decrease with aging under disturbed nutrient conditions, obesity. Additionally, decline closely related to the development of metabolic disorders, diabetes fatty liver disease. In addition, many revealed administration precursors, nicotinamide mononucleotide (NMN) riboside (NR), efficiently increase tissues prevent diseases. These precursors are contained natural foods, cow milk, vegetables, meats. Therefore, altered can be practical target nutritional intervention. Recently, several human clinical trials using been conducted investigate safety, pharmacokinetics, efficacy against disorders glucose intolerance. this review, we summarize current knowledge on implications diseases discuss outcomes recent trials.

Language: Английский

Kynurenine pathway, NAD+ synthesis, and mitochondrial function: Targeting tryptophan metabolism to promote longevity and healthspan DOI
Raúl Castro-Portuguez, George L. Sutphin

Experimental Gerontology, Journal Year: 2020, Volume and Issue: 132, P. 110841 - 110841

Published: Jan. 16, 2020

Language: Английский

Citations

205
Metabolic rearrangements in primary liver cancers: cause and consequences DOI

Letizia Satriano,

Monika Lewińska, Pedro M. Rodrigues

et al.

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2019, Volume and Issue: 16(12), P. 748 - 766

Published: Oct. 30, 2019

Language: Английский

Citations

197
Mitochondrial dysfunction, oxidative stress, neuroinflammation, and metabolic alterations in the progression of Alzheimer’s disease: A meta-analysis of in vivo magnetic resonance spectroscopy studies DOI Creative Commons
Tao Song, Xiaopeng Song,

Chenyawen Zhu

et al.

Ageing Research Reviews, Journal Year: 2021, Volume and Issue: 72, P. 101503 - 101503

Published: Oct. 29, 2021

Language: Английский

Citations

190
Bacteria Boost Mammalian Host NAD Metabolism by Engaging the Deamidated Biosynthesis Pathway DOI
Igor Shats, Jason G. Williams,

Juan Liu

et al.

Cell Metabolism, Journal Year: 2020, Volume and Issue: 31(3), P. 564 - 579.e7

Published: March 1, 2020

Language: Английский

Citations

175
Implications of altered NAD metabolism in metabolic disorders DOI Creative Commons
Keisuke Okabe, Keisuke Yaku, Kazuyuki Tobe

et al.

Journal of Biomedical Science, Journal Year: 2019, Volume and Issue: 26(1)

Published: May 11, 2019

Nicotinamide adenine dinucleotide (NAD) is an important coenzyme that participates in various energy metabolism pathways, including glycolysis, β-oxidation, and oxidative phosphorylation. Besides, it a required cofactor for post-translational modifications such as ADP-ribosylation deacetylation by poly (ADP-ribose) polymerases (PARPs) sirtuins, respectively. Thus, NAD regulates metabolism, DNA damage repair, gene expression, stress response through these enzymes. Numerous studies have shown levels decrease with aging under disturbed nutrient conditions, obesity. Additionally, decline closely related to the development of metabolic disorders, diabetes fatty liver disease. In addition, many revealed administration precursors, nicotinamide mononucleotide (NMN) riboside (NR), efficiently increase tissues prevent diseases. These precursors are contained natural foods, cow milk, vegetables, meats. Therefore, altered can be practical target nutritional intervention. Recently, several human clinical trials using been conducted investigate safety, pharmacokinetics, efficacy against disorders glucose intolerance. this review, we summarize current knowledge on implications diseases discuss outcomes recent trials.

Language: Английский

Citations

173