Frontiers in Cell and Developmental Biology,
Год журнала:
2023,
Номер
11
Опубликована: Фев. 27, 2023
Mitochondria
are
central
hubs
for
energy
production,
metabolism
and
cellular
signal
transduction
in
eukaryotic
cells.
Maintenance
of
mitochondrial
homeostasis
is
important
function
survival.
In
particular,
metabolic
state
constant
communication
with
homeostasis.
One
the
most
processes
that
provide
cell
amino
acid
metabolism.
Almost
all
20
acids
serve
as
building
blocks
proteins
produced
or
degraded
mitochondria.
The
synthesis
aspartate
arginine
depends
on
activity
respiratory
chain,
which
essential
proliferation.
degradation
branched-chain
mainly
occurs
matrix,
contributing
to
metabolism,
biogenesis,
well
protein
quality
control
both
mitochondria
cytosol.
Dietary
supplementation
restriction
worms,
flies
mice
modulates
lifespan
health,
has
been
associated
changes
antioxidant
response,
tricarboxylic
cycle
chain.
Consequently,
impaired
primary
diseases
dysfunction
such
cancer.
Here,
we
present
recent
observations
crosstalk
between
homeostasis,
summarise
underlying
molecular
mechanisms
date,
discuss
their
role
functions
organismal
physiology.
The Journal of Cell Biology,
Год журнала:
2021,
Номер
220(9)
Опубликована: Июль 30, 2021
Ferroptosis
is
a
form
of
iron-dependent
regulated
cell
death
driven
by
uncontrolled
lipid
peroxidation.
Mitochondria
are
double-membrane
organelles
that
have
essential
roles
in
energy
production,
cellular
metabolism,
and
regulation.
However,
their
role
ferroptosis
has
been
unclear
somewhat
controversial.
In
this
Perspective,
I
summarize
the
diverse
metabolic
processes
mitochondria
actively
drive
ferroptosis,
discuss
recently
discovered
mitochondria-localized
defense
systems
detoxify
mitochondrial
peroxides
protect
against
present
new
evidence
for
regulating
outline
outstanding
questions
on
fascinating
topic
future
investigations.
An
in-depth
understanding
functions
will
important
implications
both
fundamental
biology
disease
treatment.
FEBS Letters,
Год журнала:
2020,
Номер
595(8), С. 976 - 1002
Опубликована: Дек. 12, 2020
Most
of
the
genetic
information
has
been
lost
or
transferred
to
nucleus
during
evolution
mitochondria.
Nevertheless,
mitochondria
have
retained
their
own
genome
that
is
essential
for
oxidative
phosphorylation
(OXPHOS).
In
mammals,
a
gene‐dense
circular
mitochondrial
DNA
(mtDNA)
about
16.5
kb
encodes
13
proteins,
which
constitute
only
1%
proteome.
Mammalian
mtDNA
present
in
thousands
copies
per
cell
and
mutations
often
affect
fraction
them.
pathogenic
human
are
recessive
cause
OXPHOS
defects
if
above
certain
critical
threshold.
However,
emerging
evidence
strongly
suggests
proportion
mutated
not
determinant
disease
but
also
absolute
copy
number
matters.
this
review,
we
critically
discuss
current
knowledge
role
regulation
various
types
diseases,
including
disorders,
neurodegenerative
disorders
cancer,
ageing.
We
provide
an
overview
new
exciting
therapeutic
strategies
directly
manipulate
restore
diseases.
Signal Transduction and Targeted Therapy,
Год журнала:
2023,
Номер
8(1)
Опубликована: Сен. 21, 2023
Abstract
Ferroptosis
is
an
iron-dependent
form
of
regulated
cell
death
with
distinct
characteristics,
including
altered
iron
homeostasis,
reduced
defense
against
oxidative
stress,
and
abnormal
lipid
peroxidation.
Recent
studies
have
provided
compelling
evidence
supporting
the
notion
that
ferroptosis
plays
a
key
pathogenic
role
in
many
diseases
such
as
various
cancer
types,
neurodegenerative
disease,
involving
tissue
and/or
organ
injury,
inflammatory
infectious
diseases.
Although
precise
regulatory
networks
underlie
are
largely
unknown,
particularly
respect
to
initiation
progression
diseases,
recognized
bona
fide
target
for
further
development
treatment
prevention
strategies.
Over
past
decade,
considerable
progress
has
been
made
developing
pharmacological
agonists
antagonists
these
ferroptosis-related
conditions.
Here,
we
provide
detailed
overview
our
current
knowledge
regarding
ferroptosis,
its
pathological
roles,
regulation
during
disease
progression.
Focusing
on
use
chemical
tools
preclinical
studies,
also
summarize
recent
advances
targeting
across
growing
spectrum
ferroptosis-associated
Finally,
discuss
new
challenges
opportunities
potential
strategy
treating
Cell Death Discovery,
Год журнала:
2021,
Номер
7(1)
Опубликована: Окт. 5, 2021
Abstract
Characterized
by
excessive
iron
accumulation
and
lipid
peroxidation,
ferroptosis
is
a
novel
form
of
iron-dependent
cell
death,
which
morphologically,
genetically,
biochemically
distinct
from
other
well-known
death.
In
recent
years,
has
been
quickly
gaining
attention
in
the
field
liver
diseases,
as
predisposed
to
oxidative
injury
generally,
primary
characteristic
most
major
diseases.
current
review,
we
first
delineate
three
cellular
defense
mechanisms
against
(GPx4
mitochondria
cytosol,
FSP1
on
plasma
membrane,
DHODH
mitochondria),
along
with
four
canonical
modulators
(system
Xc
−
,
nuclear
factor
erythroid
2-related
2,
p53,
GTP
cyclohydrolase-1).
Next,
review
progress
studies
delineating
molecular
underlying
pathophysiology
several
common
diseases
including
ischemia/reperfusion-related
(IRI),
nonalcoholic
fatty
disease
(NAFLD),
alcoholic
(ALD),
hemochromatosis
(HH),
drug-induced
(DILI),
hepatocellular
carcinoma
(HCC).
Furthermore,
also
highlight
both
challenges
promises
that
emerged
should
be
addressed
pursued
future
investigations
before
regulation
could
adopted
an
effective
therapeutic
target
clinical
practice.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(3), С. 2606 - 2606
Опубликована: Янв. 30, 2023
Cancer
cells
undergo
metabolic
reprogramming
and
switch
to
a
‘glycolysis-dominant’
profile
promote
their
survival
meet
requirements
for
energy
macromolecules.
This
phenomenon,
also
known
as
the
‘Warburg
effect,’
provides
advantage
cancer
make
tumor
environment
more
pro-cancerous.
Additionally,
increased
glycolytic
dependence
promotes
chemo/radio
resistance.
A
similar
is
shown
by
immune
in
microenvironment,
inducing
competition
between
tumor-infiltrating
over
nutrients.
Several
recent
studies
have
that
targeting
enhanced
glycolysis
promising
strategy
them
susceptible
treatment
with
other
conventional
modalities,
including
chemotherapy,
radiotherapy,
hormonal
therapy,
immunotherapy,
photodynamic
therapy.
Although
several
strategies
been
developed
of
are
different
stages
pre-clinical
clinical
evaluation,
there
still
lack
effective
specifically
target
cell
improve
efficacy.
Herein,
we
reviewed
our
current
understanding
role
how
this
phenomenon
could
be
potential
efficacy
