Nature Cell Biology,
Год журнала:
2023,
Номер
25(5), С. 672 - 684
Опубликована: Май 1, 2023
Abstract
Dietary
mono-unsaturated
fatty
acids
(MUFAs)
are
linked
to
longevity
in
several
species.
But
the
mechanisms
by
which
MUFAs
extend
lifespan
remain
unclear.
Here
we
show
that
an
organelle
network
involving
lipid
droplets
and
peroxisomes
is
critical
for
MUFA-induced
Caenorhabditis
elegans
.
upregulate
number
of
fat
storage
tissues.
Increased
droplet
necessary
predicts
remaining
lifespan.
Lipidomics
datasets
reveal
also
modify
ratio
membrane
lipids
ether
lipids—a
signature
associated
with
decreased
oxidation.
In
agreement
this,
decrease
oxidation
middle-aged
individuals.
Intriguingly,
not
only
but
peroxisome
number.
A
targeted
screen
identifies
genes
involved
co-regulation
peroxisomes,
reveals
induction
both
organelles
optimal
longevity.
Our
study
uncovers
homeostasis
regulation,
opening
new
avenues
interventions
delay
aging.
Cell,
Год журнала:
2022,
Номер
185(14), С. 2401 - 2421
Опубликована: Июль 1, 2022
Ferroptosis,
a
form
of
cell
death
driven
by
iron-dependent
lipid
peroxidation,
was
identified
as
distinct
phenomenon
and
named
decade
ago.
Ferroptosis
has
been
implicated
in
broad
set
biological
contexts,
from
development
to
aging,
immunity,
cancer.
This
review
describes
key
regulators
this
within
framework
metabolism,
ROS
biology,
iron
biology.
Key
concepts
major
unanswered
questions
the
ferroptosis
field
are
highlighted.
The
next
promises
yield
further
breakthroughs
mechanisms
governing
additional
ways
harnessing
for
therapeutic
benefit.
Cell Death and Disease,
Год журнала:
2022,
Номер
13(4)
Опубликована: Апрель 16, 2022
Abstract
Ferroptosis,
a
newly
discovered
iron-dependent
cell
death
pathway,
is
characterized
by
lipid
peroxidation
and
GSH
depletion
mediated
iron
metabolism
morphologically,
biologically
genetically
different
from
other
programmed
deaths.
Besides,
ferroptosis
usually
found
accompanied
inflammatory
reactions.
So
far,
it
has
been
participating
in
the
development
of
many
kinds
diseases.
Macrophages
are
group
immune
cells
that
widely
exist
our
body
for
host
defense
play
an
important
role
tissue
homeostasis
mediating
inflammation
regulating
iron,
amino
acid
metabolisms
through
their
unique
functions
like
phagocytosis
efferocytosis,
cytokines
secretion
ROS
production
under
polarization.
According
to
these
common
points
characteristics
macrophages
functions,
it’s
obvious
there
must
be
relationship
between
ferroptosis.
Therefore,
review
aims
at
revealing
interaction
concerning
three
integrating
application
certain
curing
diseases,
mostly
cancer.
Finally,
we
also
provide
inspirations
further
studies
therapy
some
diseases
targeting
resident
distinct
tissues
regulate
Facts
Ferroptosis
considered
as
form
its
nonapoptotic
hydroperoxide,
metabolisms.
playing
crucial
part
various
including
hepatic
neurological
cancer,
etc.
phagocytic
cells,
existing
owning
such
production.
proved
participate
initiating
reactions
maintain
balance
body.
Recent
try
treat
cancer
altering
macrophages’
polarization
which
damages
tumor
microenvironment
induces
cells.
Open
questions
How
do
specifically?
Can
use
treating
than
cancer?
What
can
related
macrophages?
Is
more
effective
therapies
when
diseases?
