Social Determinants of Cardiovascular Disease

Circulation Research, Год журнала: 2022, Номер 130(5), С. 782 - 799

Опубликована: Март 3, 2022

Social determinants of health (SDoH), which encompass the economic, social, environmental, and psychosocial factors that influence health, play a significant role in development cardiovascular disease (CVD) risk as well CVD morbidity mortality. The COVID-19 pandemic current social justice movement sparked by death George Floyd have laid bare long-existing inequities our society driven SDoH. Despite recent focus on these structural drivers disparities, impact SDoH outcomes remains understudied incompletely understood. To further investigate mechanisms connecting CVD, ultimately design targeted effective interventions, it is important to foster interdisciplinary efforts incorporate translational, epidemiological, clinical research examining SDoH-CVD relationships. This review aims facilitate coordination intervention providing an evidence-based framework for rooted lived experiences marginalized populations. Our highlights critical structural/socioeconomic, most strongly associated with explores several underlying biologic pathogenesis, including excess stress hormones, inflammation, immune cell function, cellular aging. We present landmark studies findings about framework, careful consideration constructs measures utilized. Finally, we provide roadmap future focused individual, clinical, policy approaches directed towards developing multilevel community-engaged interventions promote health.

Язык: Английский

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The global burden of metabolic disease: Data from 2000 to 2019

Cell Metabolism, Год журнала: 2023, Номер 35(3), С. 414 - 428.e3

Опубликована: Март 1, 2023

Язык: Английский

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Global, regional, and national burden of Alzheimer's disease and other dementias, 1990–2019

Frontiers in Aging Neuroscience, Год журнала: 2022, Номер 14

Опубликована: Окт. 10, 2022

Background With the increase in aging population worldwide, Alzheimer's disease has become a rapidly increasing public health concern. Monitoring dementia burden will support development strategies by providing scientific data. Methods Based on data obtained from 2019 Global Burden of Disease (GBD) database, numbers and age-standardized rates (ASRs) incidence, prevalence, death, disability-adjusted life-years (DALYs) other dementias 1990 to were analyzed. Calculated estimated annual percentage changes (EAPCs) Joinpoint regression analyses performed evaluate trends during this period. We also evaluated correlations between epidemiology sociodemographic index (SDI), an indicator level social country or region considering education rate, economic situation, total fertility rate. Results From 2019, incidence prevalence increased 147.95 160.84%, respectively. The ASR DALYs both men women consistently over study All ASRs higher than those men, but increases more pronounced men. In addition, positively correlated with SDI. Moreover, proportion patients 70 years old was SDI level. Smoking major risk factor for while obesity women. Conclusion worldwide. This trend serious high-SDI areas, especially among elderly populations who should receive additional attention. Policy-makers take steps reverse situation. Notably, at disease, showed faster increase. give attention population, attach importance interventions targeting factors, formulate action plans address dementia.

Язык: Английский

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Global Burden, Risk Factor Analysis, and Prediction Study of Ischemic Stroke, 1990–2030

Neurology, Год журнала: 2023, Номер 101(2)

Опубликована: Май 17, 2023

Ischemic stroke (IS), 1 of the 2 main subtypes stroke, occurs because brain ischemia caused by thrombosis a cerebral blood vessel. IS is one most important neurovascular causes death and disability. It affected many risk factors, such as smoking high body mass index (BMI), which are also critical in preventive control other cardiovascular cerebrovascular diseases. However, there still few systematic analyses current predicted disease burden attributable factors IS.Based on Global Burden Disease 2019 database, we used age-standardized mortality rate disability-adjusted life year to systematically present geographical distribution trends worldwide from 1990 calculating estimated annual percentage change analyze predict number accounted 7 major for 2020-2030.Between 2019, global deaths increased 2.04 million 3.29 expected increase further 4.90 2030. The downward trend was more pronounced women, young people, sociodemographic (SDI) regions. At same time, study found that behavioral diet sodium, 5 metabolic including systolic pressure, low-density lipoprotein cholesterol, kidney dysfunction, fasting plasma glucose, BMI, contributors now future.Our provides first comprehensive summary past 30 years prediction its until 2030, providing detailed statistics decision-making prevention globally. An inadequate would lead an especially low SDI Our identifies high-risk populations helps public health professionals develop targeted strategies reduce IS.

Язык: Английский

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White adipocyte dysfunction and obesity-associated pathologies in humans

Nature Reviews Molecular Cell Biology, Год журнала: 2023, Номер 25(4), С. 270 - 289

Опубликована: Дек. 12, 2023

Язык: Английский

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Secular trends of epidemiologic patterns of chronic kidney disease over three decades: an updated analysis of the Global Burden of Disease Study 2019

BMJ Open, Год журнала: 2023, Номер 13(3), С. e064540 - e064540

Опубликована: Март 1, 2023

Objectives To assess the characteristics of global death burden imposed by chronic kidney disease (CKD) and attributable risk factors from 1990 to 2019 help inform a framework for policy discussions, resource allocation research priorities. Design A population-based observational study. Setting The data relative were obtained Global Burden Disease (GBD) Study database. Main outcome measures Based on GBD database, we estimated CKD stratified sociodemographic index (SDI), geographic location, sex, age group, time period 2019. Results Over three decade study period, number CKD-related deaths increased 0.60 million (95% uncertainty interval (UI): 0.57–0.63 million) in 1.43 UI: 1.31–1.52 age-standardised rate (ASDR) CKD, among all causes, 15th 10th Globally, ASDR males was higher than that females. mainly occurred those aged over 50 years, especially regions with SDIs. negatively related SDI (ρ=−0.603, p<0.0001). Among factors, metabolic systolic blood pressure, fasting plasma glucose body mass index, main contributors deaths. Although high-temperature-related low, trend sharply lower regions. Conclusions continue increase, majority occurring elderly adults. is Additionally, increasing burdens should receive social attention.

Язык: Английский

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Association of triglyceride-glucose index and its related parameters with atherosclerotic cardiovascular disease: evidence from a 15-year follow-up of Kailuan cohort

Cardiovascular Diabetology, Год журнала: 2024, Номер 23(1)

Опубликована: Июнь 19, 2024

Abstract Background Triglyceride glucose (TyG) index and its related parameters have been introduced as cost-effective surrogate indicators of insulin resistance, while prospective evidence their effects on atherosclerotic cardiovascular disease (ASCVD) remained scattered inconsistent. We aimed to evaluate the association TyG with new-onset ASCVD, predictive capacity were further compared. Method A total 95,342 ASCVD-free participants enrolled from Kailuan study. defined by fasting blood glucose, triglyceride, body mass (BMI), waist circumstance (WC) waist-to-height ratio (WHtR). The primary outcome was incident comprising myocardial infarction (MI) ischemic stroke (IS). Cox proportional hazard models restricted cubic spline (RCS) analyses adopted investigate between each ASCVD. C-index, integrated discrimination improvement (IDI), net reclassification (NRI) used for comparison value Results During a median follow-up 15.0 years, 8,031 new cases ASCVD identified. incidence rate increased along elevated levels index, relationships found be nonlinear in RCS analyses. (HR) 95% confidence interval (95% CI) 1.39 (1.35, 1.43), 1.46 (1.41, 1.50), 1.50 (1.46, 1.55), 1.52 (1.48, 1.57) per 1 IQR increase baseline TyG, TyG-BMI, TyG-WC, TyG-WHtR, respectively, more pronounced females younger individuals aged < 60 years ( P interaction <0.05). Using updated mean or time-varying measurements instead did not significantly alter findings. Additionally, TyG-WC TyG-WHtR showed better performance predicting risk than IDI 0.004 (0.001, 0.004) category-free NRI 0.120 (0.025, 0.138) 0.143 (0.032, 0.166), respectively. Similar findings observed MI IS. Conclusions Both positively associated had which might suitable indices stratification enhance prevention

Язык: Английский

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Major lipids and lipoprotein levels and risk of blood pressure elevation: a Mendelian Randomisation study

EBioMedicine, Год журнала: 2024, Номер 100, С. 104964 - 104964

Опубликована: Янв. 5, 2024

Quantitative nuclear magnetic resonance (NMR) metabolomics techniques provide detailed measurements of lipoprotein particle concentration. Metabolic dysfunction often represents a cluster conditions, including dyslipidaemia, hypertension, and diabetes, that increase the risk cardiovascular diseases (CVDs). However, causal relationship between lipid profiles blood pressure (BP) remains unclear. We performed Mendelian Randomisation (MR) study to disentangle prioritize potential effects major lipids, particles, circulating metabolites on BP pulse (PP).

Язык: Английский

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Global burden of cardiovascular diseases attributed to low physical activity: An analysis of 204 countries and territories between 1990 and 2019

American Journal of Preventive Cardiology, Год журнала: 2024, Номер 17, С. 100633 - 100633

Опубликована: Фев. 6, 2024

Low physical activity is a major risk factor for cardiovascular diseases (CVDs). This study aimed to estimate the global, regional, national, and sex-age-specific burden of CVDs attributed low from 1990 2019.

Язык: Английский

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Global trends in the burden of ischemic heart disease based on the global burden of disease study 2021: the role of metabolic risk factors

BMC Public Health, Год журнала: 2025, Номер 25(1)

Опубликована: Янв. 24, 2025

Ischemic heart disease (IHD) remains a leading cause of mortality and morbidity globally. This study aims to evaluate the trends in IHD burden across different socioeconomic regions using data from Global Burden Disease Study 2021 (GBD 2021) understand impact metabolic risk factors on these trends. Data GBD was analyzed global age-standardized death rates (ASDR) disability-adjusted life years (ASRDALYs) linked IHD. Key evaluated included high systolic blood pressure (SBP), low-density lipoprotein cholesterol (LDLc), fasting plasma glucose (FPG), body mass index (BMI). Temporal were assessed estimated annual percentage changes (EAPCs), with further analysis by age, sex socio-demographic (SDI). Resource-abundant showed notable reductions ASDR ASRDALYs, largely due effective management SBP LDLc, resulting an EAPC -3.43 (95% CI: -3.32, -3.53). In contrast, resource-limited regions, particularly among males, experienced stagnation or even increases burden. The low-, low-middle-, middle-SDI ranged − 0.12 -0.04, -0.19) 0.16 0.09, 0.23). Among values 0.22 0.14, 0.29) 0.55 0.47, 0.62). increase primarily driven rising levels FPG BMI. Younger populations (15–49 years) disproportionately affected, showing increasing exposure risks. Regional disparities persist, factors. have benefitted control whereas face growing challenges, especially related use secondary database provides comprehensive perspective but may not fully capture local variations Targeted public health strategies early interventions are essential reduce vulnerable populations.

Язык: Английский

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