Molecules-mediated bidirectional interactions between microbes and human cells DOI Creative Commons
Shengbo Wu, Xin Bu, Danlei Chen

и другие.

npj Biofilms and Microbiomes, Год журнала: 2025, Номер 11(1)

Опубликована: Март 4, 2025

Complex molecules-mediated interactions, which are based on the bidirectional information exchange between microbes and human cells, enable defense against diseases health maintenance. Recently, diverse single-direction interactions active metabolites, immunity factors, quorum sensing signals have largely been summarized separately. In this review, according to a simplified timeline, we proposed framework of Molecules-mediated Bidirectional Interactions (MBI) microbe humans decipher understand their intricate systematically. About microbe-derived various molecules, such as short-chain fatty acids, bile tryptophan catabolites, corresponding receptors. Concerning human-derived reviewed effect including hormones, cytokines, other circulatory metabolites microbial characteristics phenotypes. Finally, discussed challenges trends for developing deciphering molecule-mediated potential applications in guard health.

Язык: Английский

Divergence of gut bacteria through the selection of genomic variants implicated in the metabolism of sugars, amino acids, and purines by small extracellular vesicles in milk DOI Creative Commons
Fang Zhou, Peerzada Tajamul Mumtaz,

Haluk Dogan

и другие.

Gut Microbes, Год журнала: 2025, Номер 17(1)

Опубликована: Янв. 6, 2025

Here, we report that small extracellular vesicles (sEVs) in milk mediate the communication between bacteria and animal kingdoms, increase divergence of intestine, alter metabolite production by bacteria. We show bovine sEVs select approximately 55,000 genomic variants 19 species from murine cecum ex vivo. The are transcribed into mRNA. selection alters bacterial metabolism, leading to an up 12-fold difference abundance more than 1000 metabolites cultured sEV-free media compared sEV-containing media. Evidence is particularly strong sEV changes metabolism sugars, amino acids, purines which might contribute development spatial learning memory deficiencies seizure phenotypes reported for sEV-depleted infants mice. Human a rich source sEVs, whereas formula contains only trace amounts sEVs. This implicates nutritional altered microbial beyond mere communities.

Язык: Английский

Процитировано

0
Nutrition in Fattening Lambs DOI

José María Bello Dronda,

Alejandra Valentín Rincón,

Ana Cristina Vitor

и другие.

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
White matter hyperintensity severity modifies gut metabolite association with cognitive outcomes DOI Creative Commons
Naruchorn Kijpaisalratana, Chia‐Ling Phuah, Zsuzsanna Ament

и другие.

The Journal of Prevention of Alzheimer s Disease, Год журнала: 2025, Номер unknown, С. 100086 - 100086

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Metabolic insights into gut microbiota in the pharmacology of natural medicines DOI
Zixin Chen,

Junchi Zhou,

Xiao Zheng

и другие.

Chinese Journal of Natural Medicines, Год журнала: 2025, Номер 23(2), С. 158 - 168

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Molecules-mediated bidirectional interactions between microbes and human cells DOI Creative Commons
Shengbo Wu, Xin Bu, Danlei Chen

и другие.

npj Biofilms and Microbiomes, Год журнала: 2025, Номер 11(1)

Опубликована: Март 4, 2025

Complex molecules-mediated interactions, which are based on the bidirectional information exchange between microbes and human cells, enable defense against diseases health maintenance. Recently, diverse single-direction interactions active metabolites, immunity factors, quorum sensing signals have largely been summarized separately. In this review, according to a simplified timeline, we proposed framework of Molecules-mediated Bidirectional Interactions (MBI) microbe humans decipher understand their intricate systematically. About microbe-derived various molecules, such as short-chain fatty acids, bile tryptophan catabolites, corresponding receptors. Concerning human-derived reviewed effect including hormones, cytokines, other circulatory metabolites microbial characteristics phenotypes. Finally, discussed challenges trends for developing deciphering molecule-mediated potential applications in guard health.

Язык: Английский

Процитировано

0