Molecules-mediated bidirectional interactions between microbes and human cells DOI Creative Commons
Shengbo Wu, Xin Bu, Danlei Chen

et al.

npj Biofilms and Microbiomes, Journal Year: 2025, Volume and Issue: 11(1)

Published: March 4, 2025

Complex molecules-mediated interactions, which are based on the bidirectional information exchange between microbes and human cells, enable defense against diseases health maintenance. Recently, diverse single-direction interactions active metabolites, immunity factors, quorum sensing signals have largely been summarized separately. In this review, according to a simplified timeline, we proposed framework of Molecules-mediated Bidirectional Interactions (MBI) microbe humans decipher understand their intricate systematically. About microbe-derived various molecules, such as short-chain fatty acids, bile tryptophan catabolites, corresponding receptors. Concerning human-derived reviewed effect including hormones, cytokines, other circulatory metabolites microbial characteristics phenotypes. Finally, discussed challenges trends for developing deciphering molecule-mediated potential applications in guard health.

Language: Английский

Divergence of gut bacteria through the selection of genomic variants implicated in the metabolism of sugars, amino acids, and purines by small extracellular vesicles in milk DOI Creative Commons
Fang Zhou, Peerzada Tajamul Mumtaz,

Haluk Dogan

et al.

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 6, 2025

Here, we report that small extracellular vesicles (sEVs) in milk mediate the communication between bacteria and animal kingdoms, increase divergence of intestine, alter metabolite production by bacteria. We show bovine sEVs select approximately 55,000 genomic variants 19 species from murine cecum ex vivo. The are transcribed into mRNA. selection alters bacterial metabolism, leading to an up 12-fold difference abundance more than 1000 metabolites cultured sEV-free media compared sEV-containing media. Evidence is particularly strong sEV changes metabolism sugars, amino acids, purines which might contribute development spatial learning memory deficiencies seizure phenotypes reported for sEV-depleted infants mice. Human a rich source sEVs, whereas formula contains only trace amounts sEVs. This implicates nutritional altered microbial beyond mere communities.

Language: Английский

Citations

0
Nutrition in Fattening Lambs DOI

José María Bello Dronda,

Alejandra Valentín Rincón,

Ana Cristina Vitor

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
White matter hyperintensity severity modifies gut metabolite association with cognitive outcomes DOI Creative Commons
Naruchorn Kijpaisalratana, Chia‐Ling Phuah, Zsuzsanna Ament

et al.

The Journal of Prevention of Alzheimer s Disease, Journal Year: 2025, Volume and Issue: unknown, P. 100086 - 100086

Published: Feb. 1, 2025

Language: Английский

Citations

0
Metabolic insights into gut microbiota in the pharmacology of natural medicines DOI
Zixin Chen,

Junchi Zhou,

Xiao Zheng

et al.

Chinese Journal of Natural Medicines, Journal Year: 2025, Volume and Issue: 23(2), P. 158 - 168

Published: Feb. 1, 2025

Language: Английский

Citations

0
Molecules-mediated bidirectional interactions between microbes and human cells DOI Creative Commons
Shengbo Wu, Xin Bu, Danlei Chen

et al.

npj Biofilms and Microbiomes, Journal Year: 2025, Volume and Issue: 11(1)

Published: March 4, 2025

Complex molecules-mediated interactions, which are based on the bidirectional information exchange between microbes and human cells, enable defense against diseases health maintenance. Recently, diverse single-direction interactions active metabolites, immunity factors, quorum sensing signals have largely been summarized separately. In this review, according to a simplified timeline, we proposed framework of Molecules-mediated Bidirectional Interactions (MBI) microbe humans decipher understand their intricate systematically. About microbe-derived various molecules, such as short-chain fatty acids, bile tryptophan catabolites, corresponding receptors. Concerning human-derived reviewed effect including hormones, cytokines, other circulatory metabolites microbial characteristics phenotypes. Finally, discussed challenges trends for developing deciphering molecule-mediated potential applications in guard health.

Language: Английский

Citations

0