Journal of Experimental & Clinical Cancer Research,
Год журнала:
2024,
Номер
43(1)
Опубликована: Фев. 12, 2024
Nasopharyngeal
carcinoma
(NPC)
poses
a
significant
health
burden
in
specific
regions
of
Asia,
and
some
NPC
patients
have
bone
metastases
at
the
time
initial
diagnosis.
Bone
metastasis
can
cause
pathologic
fractures
pain,
reducing
patients'
quality
life,
is
associated
with
worse
survival.
This
study
aims
to
unravel
complex
role
insulin-like
growth
factor
1
receptor
(IGF-1R)
metastasis,
offering
insights
into
potential
therapeutic
targets.
We
assessed
IGF-1R
expression
cells
explored
its
correlation
metastasis.
Experiments
investigated
impact
osteoclast-secreted
IGF-1
on
IGF-1R/AKT/S6
pathway
promoting
cell
proliferation
within
marrow.
Additionally,
reciprocal
influence
tumor-secreted
Granulocyte-macrophage
colony-stimulating
(GM-CSF)
osteoclast
differentiation
resorption
was
examined.
The
effects
neutralizing
antibody,
inhibitor
(NVP-AEW541)
mTORC
(rapamycin)
nasopharyngeal
were
also
animal
experiments.
Elevated
correlated
an
increased
tendency
for
IGF-1,
secreted
by
osteoclasts,
activated
pathway,
Tumor-secreted
GM-CSF
further
stimulated
differentiation,
exacerbating
resorption.
NVP-AEW541
rapamycin
respectively
effective
slowing
down
rate
destruction.
intricate
interplay
among
IGF-1R,
highlights
targets
precise
control
providing
valuable
developing
targeted
interventions.
Cell Proliferation,
Год журнала:
2024,
Номер
57(10)
Опубликована: Май 3, 2024
Abstract
The
Hippo
signalling
pathway
is
a
conserved
kinase
cascade
that
orchestrates
diverse
cellular
processes,
such
as
proliferation,
apoptosis,
lineage
commitment
and
stemness.
With
the
onset
of
society
ages,
research
on
skeletal
aging‐mechanics‐bone
homeostasis
has
exploded.
In
recent
years,
aging
mechanical
force
in
system
have
gained
groundbreaking
progress.
Under
regulation
mechanics
aging,
crucial
role
development
bone.
We
synthesize
current
knowledge
pathway,
particularly
its
downstream
effectors
yes‐associated
protein
(YAP)
transcriptional
co‐activator
with
PDZ‐binding
motif
(TAZ),
bone
homeostasis.
discuss
specification
function
different
cell
types
by
pathway.
interactions
other
pathways,
Wnt,
transforming
growth
factor
beta
nuclear
kappa‐B,
are
also
mentioned
because
their
importance
for
modulating
Furthermore,
YAP/TAZ
been
extensively
studied
mechanotransducers.
Due
to
space
limitations,
we
focus
reviewing
how
forces
influence
fate,
communications
through
dysregulated
Summary
Efficient
regeneration
of
bone
defects
caused
by
disease
or
significant
trauma
is
a
major
challenge
in
current
medicine,
which
particularly
difficult
yet
under
the
emerging
psychological
stress
modern
society.
Notably,
brain–bone
axis
has
been
proposed
as
prominent
new
concept
recent
years,
among
autonomic
nerves
act
an
essential
and
skeletal
pathophysiological
factor
related
to
stress.
Studies
have
established
that
sympathetic
cues
lead
impairment
homeostasis
mainly
through
acting
on
mesenchymal
stem
cells
(MSCs)
their
derivatives
with
also
affecting
hematopoietic
cell
(HSC)-lineage
osteoclasts,
neural
regulation
lineages
increasingly
recognized
contribute
degenerative
disease,
osteoporosis.
This
review
summarizes
distribution
characteristics
bone,
introduces
regulatory
effects
mechanisms
MSC
HSC
lineages,
expounds
crucial
role
physiology
pathology,
acts
bridge
between
brain
bone.
With
translational
perspective,
we
further
highlight
basis
stress-induced
loss
series
pharmaceutical
therapeutic
strategies
implications
toward
regeneration.
The
summary
research
progress
this
field
will
add
knowledge
landscape
inter-organ
crosstalk
provide
medicinal
for
achievement
clinical
future.
International Journal of Oral Science,
Год журнала:
2023,
Номер
15(1)
Опубликована: Авг. 15, 2023
Abstract
The
crosstalk
between
the
nerve
and
stomatognathic
systems
plays
a
more
important
role
in
organismal
health
than
previously
appreciated
with
presence
of
emerging
concept
“brain-oral
axis”.
A
deeper
understanding
intricate
interaction
nervous
system
is
warranted,
considering
their
significant
developmental
homology
anatomical
proximity,
complex
innervation
jawbone
compared
to
other
skeletons.
In
this
review,
we
provide
an
in-depth
look
at
studies
concerning
neurodevelopment,
craniofacial
development,
congenital
anomalies
that
occur
when
two
develop
abnormally.
It
summarizes
cross-regulation
nerves
jawbones
effects
various
states
on
intrabony
distribution.
Diseases
closely
related
both
are
divided
into
diseases
caused
by
neurological
illnesses,
aberrant
system.
two-way
relationships
common
diseases,
such
as
periodontitis
neurodegenerative
disorders,
depression
oral
were
also
discussed.
This
review
provides
valuable
insights
novel
strategies
for
neuro-skeletal
tissue
engineering
early
prevention
treatment
orofacial
diseases.
Macromolecular Bioscience,
Год журнала:
2022,
Номер
23(4)
Опубликована: Дек. 27, 2022
Abstract
Exosomes,
as
messengers
of
cell‐to‐cell
communication,
have
many
functional
properties
similar
to
those
their
derived
cells.
Because
they
contain
a
large
number
bioactive
components
that
regulate
recipient
cell
behavior,
are
inanimate
and
do
not
require
external
maintenance
or
assistance.
Various
cell‐derived
exosomes
involved
in
physiological
processes
bone
tissue
repair.
Hydrogels
widely
used
scaffolding
materials
for
repair
because
3D
network
structure
resembles
the
natural
extracellular
matrix.
Moreover,
material
biological
functions
adjustable.
Exosomes
can
be
delivered
directly
damage
site
by
hydrogel,
duration
action
vivo
prolonged
slow
release.
Therefore,
exosome‐loaded
hydrogel
(Exo‐Gel)
system
is
promising
engineering.
In
this
study,
progress
application
Exo‐Gel
improvement
strategies,
problems
research
prospects
current
hydrogels
been
applied
reviewed.
Journal of Experimental & Clinical Cancer Research,
Год журнала:
2024,
Номер
43(1)
Опубликована: Фев. 12, 2024
Nasopharyngeal
carcinoma
(NPC)
poses
a
significant
health
burden
in
specific
regions
of
Asia,
and
some
NPC
patients
have
bone
metastases
at
the
time
initial
diagnosis.
Bone
metastasis
can
cause
pathologic
fractures
pain,
reducing
patients'
quality
life,
is
associated
with
worse
survival.
This
study
aims
to
unravel
complex
role
insulin-like
growth
factor
1
receptor
(IGF-1R)
metastasis,
offering
insights
into
potential
therapeutic
targets.
We
assessed
IGF-1R
expression
cells
explored
its
correlation
metastasis.
Experiments
investigated
impact
osteoclast-secreted
IGF-1
on
IGF-1R/AKT/S6
pathway
promoting
cell
proliferation
within
marrow.
Additionally,
reciprocal
influence
tumor-secreted
Granulocyte-macrophage
colony-stimulating
(GM-CSF)
osteoclast
differentiation
resorption
was
examined.
The
effects
neutralizing
antibody,
inhibitor
(NVP-AEW541)
mTORC
(rapamycin)
nasopharyngeal
were
also
animal
experiments.
Elevated
correlated
an
increased
tendency
for
IGF-1,
secreted
by
osteoclasts,
activated
pathway,
Tumor-secreted
GM-CSF
further
stimulated
differentiation,
exacerbating
resorption.
NVP-AEW541
rapamycin
respectively
effective
slowing
down
rate
destruction.
intricate
interplay
among
IGF-1R,
highlights
targets
precise
control
providing
valuable
developing
targeted
interventions.
