IGF-1R mediates crosstalk between nasopharyngeal carcinoma cells and osteoclasts and promotes tumor bone metastasis DOI Creative Commons
Kaifan Yang, Yanjun Hu, Yuanyuan Feng

и другие.

Journal of Experimental & Clinical Cancer Research, Год журнала: 2024, Номер 43(1)

Опубликована: Фев. 12, 2024

Nasopharyngeal carcinoma (NPC) poses a significant health burden in specific regions of Asia, and some NPC patients have bone metastases at the time initial diagnosis. Bone metastasis can cause pathologic fractures pain, reducing patients' quality life, is associated with worse survival. This study aims to unravel complex role insulin-like growth factor 1 receptor (IGF-1R) metastasis, offering insights into potential therapeutic targets. We assessed IGF-1R expression cells explored its correlation metastasis. Experiments investigated impact osteoclast-secreted IGF-1 on IGF-1R/AKT/S6 pathway promoting cell proliferation within marrow. Additionally, reciprocal influence tumor-secreted Granulocyte-macrophage colony-stimulating (GM-CSF) osteoclast differentiation resorption was examined. The effects neutralizing antibody, inhibitor (NVP-AEW541) mTORC (rapamycin) nasopharyngeal were also animal experiments. Elevated correlated an increased tendency for IGF-1, secreted by osteoclasts, activated pathway, Tumor-secreted GM-CSF further stimulated differentiation, exacerbating resorption. NVP-AEW541 rapamycin respectively effective slowing down rate destruction. intricate interplay among IGF-1R, highlights targets precise control providing valuable developing targeted interventions.

Язык: Английский

The Hippo signalling pathway in bone homeostasis: Under the regulation of mechanics and aging DOI Creative Commons
Zhengda Li, Junqing Lin, Jing Wu

и другие.

Cell Proliferation, Год журнала: 2024, Номер 57(10)

Опубликована: Май 3, 2024

Abstract The Hippo signalling pathway is a conserved kinase cascade that orchestrates diverse cellular processes, such as proliferation, apoptosis, lineage commitment and stemness. With the onset of society ages, research on skeletal aging‐mechanics‐bone homeostasis has exploded. In recent years, aging mechanical force in system have gained groundbreaking progress. Under regulation mechanics aging, crucial role development bone. We synthesize current knowledge pathway, particularly its downstream effectors yes‐associated protein (YAP) transcriptional co‐activator with PDZ‐binding motif (TAZ), bone homeostasis. discuss specification function different cell types by pathway. interactions other pathways, Wnt, transforming growth factor beta nuclear kappa‐B, are also mentioned because their importance for modulating Furthermore, YAP/TAZ been extensively studied mechanotransducers. Due to space limitations, we focus reviewing how forces influence fate, communications through dysregulated

Язык: Английский

Процитировано

6

Autonomic neural regulation in mediating the brain–bone axis: mechanisms and implications for regeneration under psychological stress DOI Open Access
Chao Ma, Yujie Zhang, Yuwei Cao

и другие.

QJM, Год журнала: 2023, Номер 117(2), С. 95 - 108

Опубликована: Май 30, 2023

Summary Efficient regeneration of bone defects caused by disease or significant trauma is a major challenge in current medicine, which particularly difficult yet under the emerging psychological stress modern society. Notably, brain–bone axis has been proposed as prominent new concept recent years, among autonomic nerves act an essential and skeletal pathophysiological factor related to stress. Studies have established that sympathetic cues lead impairment homeostasis mainly through acting on mesenchymal stem cells (MSCs) their derivatives with also affecting hematopoietic cell (HSC)-lineage osteoclasts, neural regulation lineages increasingly recognized contribute degenerative disease, osteoporosis. This review summarizes distribution characteristics bone, introduces regulatory effects mechanisms MSC HSC lineages, expounds crucial role physiology pathology, acts bridge between brain bone. With translational perspective, we further highlight basis stress-induced loss series pharmaceutical therapeutic strategies implications toward regeneration. The summary research progress this field will add knowledge landscape inter-organ crosstalk provide medicinal for achievement clinical future.

Язык: Английский

Процитировано

13

The interaction between the nervous system and the stomatognathic system: from development to diseases DOI Creative Commons
Yuzhu Wu, Yanhua Lan, Jiajie Mao

и другие.

International Journal of Oral Science, Год журнала: 2023, Номер 15(1)

Опубликована: Авг. 15, 2023

Abstract The crosstalk between the nerve and stomatognathic systems plays a more important role in organismal health than previously appreciated with presence of emerging concept “brain-oral axis”. A deeper understanding intricate interaction nervous system is warranted, considering their significant developmental homology anatomical proximity, complex innervation jawbone compared to other skeletons. In this review, we provide an in-depth look at studies concerning neurodevelopment, craniofacial development, congenital anomalies that occur when two develop abnormally. It summarizes cross-regulation nerves jawbones effects various states on intrabony distribution. Diseases closely related both are divided into diseases caused by neurological illnesses, aberrant system. two-way relationships common diseases, such as periodontitis neurodegenerative disorders, depression oral were also discussed. This review provides valuable insights novel strategies for neuro-skeletal tissue engineering early prevention treatment orofacial diseases.

Язык: Английский

Процитировано

12

Exosome‐Hydrogel System in Bone Tissue Engineering: A Promising Therapeutic Strategy DOI
Junwu Wang, Mengyue Zhu, Yingkun Hu

и другие.

Macromolecular Bioscience, Год журнала: 2022, Номер 23(4)

Опубликована: Дек. 27, 2022

Abstract Exosomes, as messengers of cell‐to‐cell communication, have many functional properties similar to those their derived cells. Because they contain a large number bioactive components that regulate recipient cell behavior, are inanimate and do not require external maintenance or assistance. Various cell‐derived exosomes involved in physiological processes bone tissue repair. Hydrogels widely used scaffolding materials for repair because 3D network structure resembles the natural extracellular matrix. Moreover, material biological functions adjustable. Exosomes can be delivered directly damage site by hydrogel, duration action vivo prolonged slow release. Therefore, exosome‐loaded hydrogel (Exo‐Gel) system is promising engineering. In this study, progress application Exo‐Gel improvement strategies, problems research prospects current hydrogels been applied reviewed.

Язык: Английский

Процитировано

17

IGF-1R mediates crosstalk between nasopharyngeal carcinoma cells and osteoclasts and promotes tumor bone metastasis DOI Creative Commons
Kaifan Yang, Yanjun Hu, Yuanyuan Feng

и другие.

Journal of Experimental & Clinical Cancer Research, Год журнала: 2024, Номер 43(1)

Опубликована: Фев. 12, 2024

Nasopharyngeal carcinoma (NPC) poses a significant health burden in specific regions of Asia, and some NPC patients have bone metastases at the time initial diagnosis. Bone metastasis can cause pathologic fractures pain, reducing patients' quality life, is associated with worse survival. This study aims to unravel complex role insulin-like growth factor 1 receptor (IGF-1R) metastasis, offering insights into potential therapeutic targets. We assessed IGF-1R expression cells explored its correlation metastasis. Experiments investigated impact osteoclast-secreted IGF-1 on IGF-1R/AKT/S6 pathway promoting cell proliferation within marrow. Additionally, reciprocal influence tumor-secreted Granulocyte-macrophage colony-stimulating (GM-CSF) osteoclast differentiation resorption was examined. The effects neutralizing antibody, inhibitor (NVP-AEW541) mTORC (rapamycin) nasopharyngeal were also animal experiments. Elevated correlated an increased tendency for IGF-1, secreted by osteoclasts, activated pathway, Tumor-secreted GM-CSF further stimulated differentiation, exacerbating resorption. NVP-AEW541 rapamycin respectively effective slowing down rate destruction. intricate interplay among IGF-1R, highlights targets precise control providing valuable developing targeted interventions.

Язык: Английский

Процитировано

4