G3 Genes Genomes Genetics,
Год журнала:
2024,
Номер
14(9)
Опубликована: Июнь 26, 2024
Abstract
Multicopied
mitogenome
are
prone
to
mutation
during
replication
often
resulting
in
heteroplasmy.
The
derived
variants
a
cell,
organ,
or
an
individual
animal
constitute
mitogene
pool.
pool
is
initiated
by
small
fraction
of
the
egg
However,
characteristics
and
relationship
between
them
has
not
yet
been
investigated.
This
study
quantitatively
analyzed
heteroplasmy
landscape,
genetic
loads,
selection
strength
hatchling
silver
carp
(Hypophthalmichthys
molitrix)
using
high-throughput
resequencing.
results
showed
heteroplasmic
sites
distribute
across
whole
both
eggs
hatchlings.
dominant
substitution
was
Transversion
Transition
hatching
accounting
for
95.23%±2.07%
85.38%±6.94%
total
HP
sites,
respectively.
loads
were
0.293±0.044
0.228±0.022
hatchlings
(P=0.048).
dN/dS
ratio
58.03±38.98
9.44±3.93
(P=0.037).
These
suggest
that
mitogenomes
under
strong
positive
with
tolerance
deleterious
effects,
while
but
much
weaker
showing
marked
quality
control.
Based
on
these
findings,
we
proposed
trans-generation
dynamics
model
explain
differential
development
mode
two
oocyte
maturation
ontogenesis
offspring.
sheds
light
significance
persistence
populations
subsequent
integration
ecological
studies
conservation
practices.
Diabetology & Metabolic Syndrome,
Год журнала:
2023,
Номер
15(1)
Опубликована: Ноя. 6, 2023
Abstract
Obese
sarcopenia
is
a
severe
and
prevalent
disease
in
an
aging
society.
Compared
to
alone,
the
development
advanced
stage
of
obesity
faster
more
severe.
Diagnosis
cause
adipocyte
accumulation
also
complicated;
however,
no
effective
pharmacological
treatment
available.
Chronic
inflammation
one
causes
sarcopenia,
obese
patients,
who
are
likely
develop
chronic
inflammation,
may
simultaneously
suffer
from
sarcopenia.
Mitochondrial
metabolic
disorders
have
been
easily
observed
tissue
cells
patients
with
include
abnormal
mtDNA
release,
mitochondrial
autophagy,
dynamic
disorders.
Therefore,
this
review
will
reveal
mechanism
myasthenia
gravis
perspective
mitochondria
discuss
currently
existing
small-molecule
drugs.
Journal of Translational Genetics and Genomics,
Год журнала:
2023,
Номер
unknown
Опубликована: Янв. 1, 2023
Maintenance
of
genome
integrity
is
essential
for
cellular
survival.
There
are
mechanisms
utilized
by
the
cells
to
sense
and
respond
assaults
on
genomic
DNA.
These
conserved
across
all
domains
life
collectively
called
DNA
damage
response
pathways.
However,
eukaryotic
also
have
extrachromosomal
in
mitochondria
(mtDNA),
which
indispensable
mitochondrial
function,
hence
cell
Indeed,
impaired
activity
arising
due
mutations
mtDNA
has
been
found
be
associated
with
many
human
pathologies.
Despite
its
importance,
our
understanding
how
ensure
limited.
Since
do
not
encode
machinery
required
maintenance
their
own
genomes,
they
depend
nucleus
replication,
transcription,
repair
processes.
This
adds
a
layer
complexity
requirement
organelle
crosstalk
coordination
damage.
review
summarizes
recent
findings
that
provide
new
insights
into
involved
quality
control,
acting
at
level
or
discusses
few
avenues
research
towards
comprehensive
"mtDNA
response".
G3 Genes Genomes Genetics,
Год журнала:
2024,
Номер
14(9)
Опубликована: Июнь 26, 2024
Abstract
Multicopied
mitogenome
are
prone
to
mutation
during
replication
often
resulting
in
heteroplasmy.
The
derived
variants
a
cell,
organ,
or
an
individual
animal
constitute
mitogene
pool.
pool
is
initiated
by
small
fraction
of
the
egg
However,
characteristics
and
relationship
between
them
has
not
yet
been
investigated.
This
study
quantitatively
analyzed
heteroplasmy
landscape,
genetic
loads,
selection
strength
hatchling
silver
carp
(Hypophthalmichthys
molitrix)
using
high-throughput
resequencing.
results
showed
heteroplasmic
sites
distribute
across
whole
both
eggs
hatchlings.
dominant
substitution
was
Transversion
Transition
hatching
accounting
for
95.23%±2.07%
85.38%±6.94%
total
HP
sites,
respectively.
loads
were
0.293±0.044
0.228±0.022
hatchlings
(P=0.048).
dN/dS
ratio
58.03±38.98
9.44±3.93
(P=0.037).
These
suggest
that
mitogenomes
under
strong
positive
with
tolerance
deleterious
effects,
while
but
much
weaker
showing
marked
quality
control.
Based
on
these
findings,
we
proposed
trans-generation
dynamics
model
explain
differential
development
mode
two
oocyte
maturation
ontogenesis
offspring.
sheds
light
significance
persistence
populations
subsequent
integration
ecological
studies
conservation
practices.
