The neuroscience of cancer

Nature, Год журнала: 2023, Номер 618(7965), С. 467 - 479

Опубликована: Июнь 14, 2023

Язык: Английский

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How cancer hijacks the body’s homeostasis through the neuroendocrine system

Trends in Neurosciences, Год журнала: 2023, Номер 46(4), С. 263 - 275

Опубликована: Фев. 17, 2023

Язык: Английский

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Ablation of Gap Junction Protein Improves the Efficiency of Nanozyme‐Mediated Catalytic/Starvation/Mild‐Temperature Photothermal Therapy

Advanced Materials, Год журнала: 2023, Номер 35(22)

Опубликована: Март 25, 2023

Reactive oxygen species (ROS)-mediated tumor catalytic therapy is typically hindered by gap junction proteins that form cell-to-cell channels to remove cytotoxic ROS, thereby protecting cells from oxidative damage. In this work, a multifunctional nanozyme, FePGOGA, designed and prepared Fe(III)-mediated polymerization (FeP), followed glucose oxidase (GOx) GAP19 peptides co-loading through electrostatic π-π interactions. The FePGOGA nanozyme exhibits excellent cascade peroxidase- glutathione-oxidase-like activities efficiently catalyze hydrogen peroxide conversion hydroxyl radicals convert reduced glutathione oxidized disulfide. loaded GOx starves the tumors aggravates stress decomposition, while block hemichannels inducing degradation of Cx43, thus increasing accumulation intracellular decreasing transport glucose. Furthermore, ROS reacts with primary amines heat shock destroy their structure function, enabling photothermal at widely sought-after mild temperature (mildPTT, ≤45 °C). vivo experiments demonstrate significant antitumor effectof on cal27 xenograft under near-infrared light irradiation. This study demonstrates successful ablation overcome resistance ROS-mediated therapy, providing regulator suppress self-preservation during starvation, mildPTT.

Язык: Английский

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Metabolic heterogeneity in cancer

Nature Metabolism, Год журнала: 2024, Номер 6(1), С. 18 - 38

Опубликована: Янв. 24, 2024

Язык: Английский

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Nerve Growth Factor and the Role of Inflammation in Tumor Development

Current Issues in Molecular Biology, Год журнала: 2024, Номер 46(2), С. 965 - 989

Опубликована: Янв. 23, 2024

Nerve growth factor (NGF) plays a dual role both in inflammatory states and cancer, acting as pro-inflammatory oncogenic an anti-inflammatory pro-apoptotic mediator context-dependent way based on the signaling networks its interaction with diverse cellular components within microenvironment. This report aims to provide summary subsequent review of literature NGF regulating microenvironment tumor cell growth, survival, death. The inflammation tumorigenesis component system, various respective microenvironments, ability cause epigenetic changes, treatment cancer have been highlighted this paper.

Язык: Английский

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Metabolic reprogramming and therapeutic resistance in primary and metastatic breast cancer

Molecular Cancer, Год журнала: 2024, Номер 23(1)

Опубликована: Ноя. 21, 2024

Metabolic alterations, a hallmark of cancer, enable tumor cells to adapt their environment by modulating glucose, lipid, and amino acid metabolism, which fuels rapid growth contributes treatment resistance. In primary breast metabolic shifts such as the Warburg effect enhanced lipid synthesis are closely linked chemotherapy failure. Similarly, metastatic lesions often display distinct profiles that not only sustain but also confer resistance targeted therapies immunotherapies. The review emphasizes two major aspects: mechanisms driving in both how unique environments sites further complicate treatment. By targeting vulnerabilities at stages, new strategies could improve efficacy existing provide better outcomes for cancer patients.

Язык: Английский

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Nociceptive neurons promote gastric tumour progression via a CGRP–RAMP1 axis

Nature, Год журнала: 2025, Номер unknown

Опубликована: Фев. 19, 2025

Язык: Английский

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Redox regulation: mechanisms, biology and therapeutic targets in diseases

Signal Transduction and Targeted Therapy, Год журнала: 2025, Номер 10(1)

Опубликована: Март 7, 2025

Redox signaling acts as a critical mediator in the dynamic interactions between organisms and their external environment, profoundly influencing both onset progression of various diseases. Under physiological conditions, oxidative free radicals generated by mitochondrial respiratory chain, endoplasmic reticulum, NADPH oxidases can be effectively neutralized NRF2-mediated antioxidant responses. These responses elevate synthesis superoxide dismutase (SOD), catalase, well key molecules like nicotinamide adenine dinucleotide phosphate (NADPH) glutathione (GSH), thereby maintaining cellular redox homeostasis. Disruption this finely tuned equilibrium is closely linked to pathogenesis wide range Recent advances have broadened our understanding molecular mechanisms underpinning dysregulation, highlighting pivotal roles genomic instability, epigenetic modifications, protein degradation, metabolic reprogramming. findings provide foundation for exploring regulation mechanistic basis improving therapeutic strategies. While antioxidant-based therapies shown early promise conditions where stress plays primary pathological role, efficacy diseases characterized complex, multifactorial etiologies remains controversial. A deeper, context-specific signaling, particularly redox-sensitive proteins, designing targeted aimed at re-establishing balance. Emerging small molecule inhibitors that target specific cysteine residues proteins demonstrated promising preclinical outcomes, setting stage forthcoming clinical trials. In review, we summarize current intricate relationship disease also discuss how these insights leveraged optimize strategies practice.

Язык: Английский

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Unraveling the peripheral nervous System's role in tumor: A Double-edged Sword

Cancer Letters, Год журнала: 2025, Номер 611, С. 217451 - 217451

Опубликована: Янв. 8, 2025

Язык: Английский

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Li–Mg–Si bioceramics provide a dynamic immuno-modulatory and repair-supportive microenvironment for peripheral nerve regeneration

Bioactive Materials, Год журнала: 2023, Номер 28, С. 227 - 242

Опубликована: Май 30, 2023

Biomaterials can modulate the local immune and repair-supportive microenvironments to promote peripheral nerve regeneration. Inorganic bioceramics have been widely used for regulating tissue regeneration response. However, little is known on whether inorganic potential enhancing what are mechanisms underlying their actions. Here, lithium-magnesium-silicon (Li-Mg-Si, LMS) containing scaffolds fabricated characterized. The LMS-containing had no cytotoxicity against rat Schwann cells (SCs), but promoted migration differentiation towards a remyelination state by up-regulating expression of neurotrophic factors in β-catenin-dependent manner. Furthermore, using single cell-sequencing, we showed that macrophage polarization pro-regenerative M2-like cells, which subsequently facilitated SCs. Moreover, implantation with guidance conduits (NGCs) increased frequency infiltration enhanced motor functional recovery model sciatic injury. Collectively, these findings indicated LMS offered strategy modulating microenvironment promoting SCs remyelination.

Язык: Английский

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