Journal of Controlled Release, Год журнала: 2025, Номер 381, С. 113580 - 113580
Опубликована: Фев. 28, 2025
Язык: Английский
Coordination Chemistry Reviews, Год журнала: 2023, Номер 491, С. 215245 - 215245
Опубликована: Май 22, 2023
Язык: Английский
Процитировано
84
Nano-Micro Letters, Год журнала: 2023, Номер 16(1)
Опубликована: Ноя. 21, 2023
Since the discovery of enzyme-like activity Fe
Язык: Английский
Процитировано
62
Deleted Journal, Год журнала: 2023, Номер 1(4)
Опубликована: Сен. 19, 2023
Abstract Enzymes are highly efficient catalysts employed in the biomedical field. However, their use is limited by poor stability and high cost. To address this, there an imperative need for research on nanozymes. In last decade, introduction of nanozymes has led to exponential growth nanozyme‐based biosensors. The rapid precise detection clinical biomarkers crucial various disease diagnostics. recent years, researchers have developed different catalytic active nanomaterials combined them with colorimetric, fluorescent, electrochemical methods detect biomarkers. This review critically overviews progress, future prospects, challenges biomarker assays past few years.
Язык: Английский
Процитировано
55
Advanced Functional Materials, Год журнала: 2023, Номер 33(48)
Опубликована: Июль 21, 2023
Abstract Single‐atom nanozymes (SAzymes) are considered as the most promising candidates for natural enzymes due to their atomically dispersed active sites that closely resemble metal centers of counterparts. However, a significant challenge still exists improving catalytic activities, retarding practical applications. Herein, this article presents through application human self‐driven triboelectric device impose electrical stimulus, multiple enzyme‐like activities single‐atom copper nanozyme (Cu‐NC) remarkably improved, thereby boosting cancer cell oxidative damage and death realizing improved therapy. Under an stimulus with 20 V voltage, peroxidase, catalase, oxidase, glutathione oxidase like Cu‐NC all boost generation free radicals. Through calculation, work analyzes how modulates activity via decreasing adsorption energy H 2 O on Cu sites, increasing d xy orbital near Fermi level, shifting d‐band center Cu, facilitating reactions. This opens new perspectives nanoenzymes
Язык: Английский
Процитировано
48
Acta Biomaterialia, Год журнала: 2023, Номер 168, С. 580 - 592
Опубликована: Июль 13, 2023
Язык: Английский
Процитировано
43
Surfaces and Interfaces, Год журнала: 2024, Номер 45, С. 103846 - 103846
Опубликована: Янв. 3, 2024
Язык: Английский
Процитировано
36
Coordination Chemistry Reviews, Год журнала: 2024, Номер 517, С. 215937 - 215937
Опубликована: Июнь 15, 2024
Язык: Английский
Процитировано
27
Coordination Chemistry Reviews, Год журнала: 2024, Номер 504, С. 215654 - 215654
Опубликована: Янв. 20, 2024
Язык: Английский
Процитировано
18
Advanced Healthcare Materials, Год журнала: 2023, Номер 13(1)
Опубликована: Сен. 24, 2023
Copper (Cu), an indispensable trace element within the human body, serving as intrinsic constituent of numerous natural enzymes, carrying out vital biological functions. Furthermore, nanomaterials exhibiting enzyme-mimicking properties, commonly known nanozymes, possess distinct advantages over their enzyme counterparts, including cost-effectiveness, enhanced stability, and adjustable performance. These advantageous attributes have captivated attention researchers, inspiring them to devise various Cu-based nanomaterials, such copper oxide, Cu metal-organic framework, CuS, explore potential in enzymatic catalysis. This comprehensive review encapsulates most recent advancements illuminating applications realm biochemistry. Initially, it is delved into emulation typical types achieved by nanomaterials. Subsequently, latest breakthroughs concerning nanozymes biochemical sensing, bacterial inhibition, cancer therapy, neurodegenerative diseases treatment discussed. Within this segment, also explored modulation nanozyme activity. Finally, a visionary outlook for future development presented.
Язык: Английский
Процитировано
40
ACS Applied Bio Materials, Год журнала: 2023, Номер 6(9), С. 3577 - 3599
Опубликована: Авг. 17, 2023
Nanozymes are nanoparticles with intrinsic enzyme-mimicking properties that have become more prevalent because of their ability to outperform conventional enzymes by overcoming drawbacks related stability, cost, and storage. the potential manipulate active sites natural enzymes, which is why they considered promising candidates function as enzyme mimetics. Several microscopy- spectroscopy-based techniques been used for characterization nanozymes. To date, a wide range nanozymes, including catalase, oxidase, peroxidase, superoxide dismutase, designed effectively mimic enzymes. The activity nanozymes can be controlled regulating structural morphological aspects multifaceted benefits, exploited on large scale application in biomedical sector. versatility aids monitoring treating cancer, other neurodegenerative diseases, metabolic disorders. Due compelling advantages significant research advancements made this area. Although act potent mimetics specificities suboptimal, there still room diversification analytical purposes. Designing diverse nanozyme systems sensitive one or substrates through specialized has subject an in-depth study. Hence, we believe stimuli-responsive may open avenues diagnosis treatment fusing catalytic nanomaterial systems.
Язык: Английский
Процитировано
37