The Potential of Superoxide Dismutase-Rich Tetraselmis chuii as a Promoter of Cellular Health

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(4), С. 1693 - 1693

Опубликована: Фев. 16, 2025

Tetraselmis chuii (T. chuii) is a green, marine, eukaryotic, microalgae that was authorized in the European Union (EU) as novel food for human consumption 2014, and supplement 2017. This narrative review will provide an overview of preclinical clinical trials assessing efficacy T. chuii-derived ingredient, characterized by high superoxide dismutase (SOD) activity (SOD-rich chuii), to improve various aspects cellular health. Collectively, results from vitro, more importantly vivo research, support SOD-rich potential promoter Principally, ingredient appears function indirect antioxidant boosting intracellular systems. Moreover, it can positively modulate inflammatory status up-regulating anti-inflammatory down-regulating pro-inflammatory cytokines factors. In addition, promote health though protecting DNA damage, immune function, strengthening cell structure integrity, modulating signaling pathways. There also some evidence suggest may mitochondrial through up-regulation genes linked biogenesis ATP synthesis. From conducted date, transcriptional activation nuclear factor erythroid 2-related 2 (NRF2) sirtuin 1 (SIRT1) appear be important mediating effects on These exciting preliminary observations represent natural blue with enhance

Язык: Английский

---

Carbon-Coated Iron Oxide Nanoparticles Promote Reductive Stress-Mediated Cytotoxic Autophagy in Drug-Induced Senescent Breast Cancer Cells

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(12), С. 15457 - 15478

Опубликована: Март 14, 2024

The surface modification of magnetite nanoparticles (Fe3O4 NPs) is a promising approach to obtaining biocompatible and multifunctional nanoplatforms with numerous applications in biomedicine, for example, fight cancer. However, little known about the effects Fe3O4 NP-associated reductive stress against cancer cells, especially chemotherapy-induced drug-resistant senescent cells. In present study, NPs situ coated by dextran (Fe3O4@Dex) glucosamine-based amorphous carbon coating (Fe3O4@aC) potent activity were characterized tested drug-induced breast cells (Hs 578T, BT-20, MDA-MB-468, MDA-MB-175-VII cells). Fe3O4@aC caused decrease reactive oxygen species (ROS) production an increase levels antioxidant proteins FOXO3a, SOD1, GPX4 that was accompanied elevated cell cycle inhibitors (p21, p27, p57), proinflammatory (NFκB, IL-6, IL-8) autophagic (BECN1, LC3B) markers, nucleolar stress, subsequent apoptotic death etoposide-stimulated also promoted stress-mediated cytotoxicity nonsenescent We postulate NPs, addition their well-established hyperthermia oxidative anticancer effects, can be considered, if modified using activity, as stimulators cytotoxic both different gene mutation statuses.

Язык: Английский

---

Reactive oxygen species control protein degradation at the mitochondrial import gate

Molecular Cell, Год журнала: 2024, Номер 84(23), С. 4612 - 4628.e13

Опубликована: Дек. 1, 2024

Язык: Английский

---

Dissecting the pleiotropic roles of reactive oxygen species (ROS) in lung cancer: From carcinogenesis toward therapy

Medicinal Research Reviews, Год журнала: 2024, Номер 44(4), С. 1566 - 1595

Опубликована: Янв. 29, 2024

Lung cancer is a major cause of morbidity and mortality. The specific pulmonary structure to directly connect with ambient air makes it more susceptible damage from airborne toxins. External oxidative stimuli endogenous reactive oxygen species (ROS) play crucial role in promoting lung carcinogenesis development. biological properties higher ROS levels tumor cells than normal make them sensitive vulnerable injury. Therefore, the strategy targeting has been proposed for therapy decades. However, embarrassing that countless attempts at ROS-based therapies have had very limited success, no FDA approval anticancer list was mechanistically based on manipulation. Even compared untargetable proteins, such as transcription factors, are difficult be targeted due their chemical properties. Thus, pleiotropic roles provide therapeutic potential drug discovery, while better dissection mechanistic action signaling pathways prerequisite future breakthroughs. This review discusses critical carcinogenesis, ROS-inspired pathways, treatment, exemplified by cancer. In particular, an eight considerations rule ROS-targeting strategies design

Язык: Английский

---

A NRF2 Regulated and the Immunosuppressive Microenvironment Reversed Nanoplatform for Cholangiocarcinoma Photodynamic‐Gas Therapy

Advanced Science, Год журнала: 2024, Номер 11(14)

Опубликована: Фев. 2, 2024

Abstract Photodynamic therapy (PDT) is a minimally invasive and controllable local cancer treatment for cholangiocarcinoma (CCA). However, the efficacy of PDT hindered by intratumoral hypoxia presence an antioxidant microenvironment. To address these limitations, combining with gas may be promising strategy to enhance tumor oxygenation. Moreover, augmentation oxidative damage induced can achieved inhibiting NRF2, core regulatory molecule involved in response. In this study, integrated nanotherapeutic platform called CMArg@Lip, incorporating therapies using ROS‐responsive liposomes encapsulating photosensitizer Ce6, NO gas‐generating agent L‐arginine, NRF2 inhibitor ML385, successfully developed. The utilization CMArg@Lip effectively deals challenges posed microenvironment, resulting elevated levels subsequent induction ferroptosis CCA. Additionally, findings suggest that exhibits notable immunomodulatory effects, including promotion immunogenic cell death facilitation dendritic maturation. Furthermore, it contributes anti‐tumor function cytotoxic T lymphocytes through downregulation PD‐L1 expression cells activation STING signaling pathway myeloid‐derived suppressor cells, thereby reprogramming immunosuppressive microenvironment via various mechanisms.

Язык: Английский

---

Photothermal and ferroptosis synergistic therapy for liver cancer using iron-doped polydopamine nanozymes

Colloids and Surfaces B Biointerfaces, Год журнала: 2024, Номер 239, С. 113911 - 113911

Опубликована: Апрель 11, 2024

Язык: Английский

---

Reductive stress: The key pathway in metabolic disorders induced by overnutrition

Journal of Advanced Research, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

The balance of redox states is crucial for maintaining physiological homeostasis. For decades, the focus has been mainly on concept oxidative stress, which involved in mechanism almost all diseases. However, robust evidence highlighted that reductive other side spectrum, plays a pivotal role development various diseases, particularly those related to metabolism and cardiovascular health. In this review, we present an extensive array occurrence stress its significant implications metabolic Reductive defined as shift cellular towards more reduced state, characterized by excess endogenous reductants (such NADH, NADPH, GSH) over their oxidized counterparts (NAD+, NADP+, GSSG). While predominant studied obesity, disorders, growing underscores critical stress. This review discusses how contributes pathologies, emphasizing effects key processes. example, excessive NADH accumulation can disrupt mitochondrial function impairing electron transport chain, leading decreased ATP production increased reactive oxygen species. endoplasmic reticulum (ER), equivalents hampers protein folding, triggering ER activating unfolded response, lead insulin resistance compromised Furthermore, explore antioxidant supplementation exacerbate further shifting balance, potentially undermining beneficial exercise, health, aggravating obese individuals. body calls reevaluation disease pathogenesis therapeutic interventions.

Язык: Английский

---

Health position paper and redox perspectives – Bench to Bedside Transition for Pharmacological Regulation of NRF2 in Noncommunicable Diseases

Redox Biology, Год журнала: 2025, Номер unknown, С. 103569 - 103569

Опубликована: Март 1, 2025

Nuclear factor erythroid 2-related 2 (NRF2) is a redox-activated transcription regulating cellular defense against oxidative stress, thereby playing pivotal role in maintaining homeostasis. Its dysregulation implicated the progression of wide array human diseases, making NRF2 compelling target for therapeutic interventions. However, challenges persist drug discovery and safe targeting NRF2, as unresolved questions remain especially regarding its context-specific diseases off-target effects. This comprehensive review discusses dualistic disease pathophysiology, covering protective and/or destructive roles autoimmune, respiratory, cardiovascular, metabolic well digestive system cancer. Additionally, we also development drugs that either activate or inhibit discuss main barriers translating NRF2-based therapies from bench to bedside, consider ways monitor activation vivo.

Язык: Английский

---

Translocation renal cell carcinoma says no to the Warburg effect

Nature Metabolism, Год журнала: 2025, Номер unknown

Опубликована: Фев. 6, 2025

Язык: Английский

---

Ferroptosis: iron release mechanisms in the bioenergetic process

Cancer and Metastasis Reviews, Год журнала: 2025, Номер 44(1)

Опубликована: Фев. 25, 2025

Язык: Английский

---