Liver Research,
Год журнала:
2023,
Номер
7(3), С. 165 - 176
Опубликована: Сен. 1, 2023
Bile
acids
(BAs)
play
important
roles
in
the
digestion
of
dietary
fats
and
molecular
signal
transduction,
modulation
BA
composition
usually
affects
progression
metabolic
diseases.
While
liver
produces
primary
BAs,
gut
microbiota
modifies
these
products
into
various
forms
that
greatly
increase
their
diversity
biological
functions.
Mechanistically,
BAs
can
regulate
own
metabolism
transport
as
well
other
key
aspects
processes
via
dedicated
receptors.
Disruption
homeostasis
leads
to
diseases,
including
dysfunction-associated
steatotic
disease
(MASLD)
hepatocellular
carcinoma
(HCC).
Here,
we
summarize
microbial
transformations
downstream
signaling
development
diseases
present
new
insights
novel
therapeutic
strategies
targeting
pathways
may
contribute
Cell,
Год журнала:
2024,
Номер
187(11), С. 2717 - 2734.e33
Опубликована: Апрель 22, 2024
The
gut
microbiota
has
been
found
to
play
an
important
role
in
the
progression
of
metabolic
dysfunction-associated
steatohepatitis
(MASH),
but
mechanisms
have
not
established.
Here,
by
developing
a
click-chemistry-based
enrichment
strategy,
we
identified
several
microbial-derived
bile
acids,
including
previously
uncharacterized
3-succinylated
cholic
acid
(3-sucCA),
which
is
negatively
correlated
with
liver
damage
patients
liver-tissue-biopsy-proven
fatty
disease
(MAFLD).
By
screening
human
bacterial
isolates,
Bacteroides
uniformis
strains
as
effective
producers
3-sucCA
both
vitro
and
vivo.
activity-based
protein
purification
identification,
enzyme
annotated
β-lactamase
B.
responsible
for
biosynthesis.
Furthermore,
that
lumen-restricted
metabolite
alleviates
MASH
promoting
growth
Akkermansia
muciniphila.
Together,
our
data
offer
new
insights
into
microbiota-liver
axis
may
be
leveraged
augment
management
MASH.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Май 22, 2024
Abstract
With
the
increasing
trend
of
global
aging,
sarcopenia
has
become
a
significant
public
health
issue.
Goji
berry,
also
known
as
“Gou
qi
zi”
in
China,
is
traditional
Chinese
herb
that
can
enhance
structure
and
function
muscles
bones.
Otherwise,
previous
excellent
publications
illustrated
plant-derived
exosome-like
nanoparticles
exert
good
bioactive
functions
different
aging
or
disease
models.
Thus,
we
issued
hypothesis
Gouqi-derived
nanovesicles
(GqDNVs)
may
have
ability
to
improve
skeletal
muscle
health,
though
effect
its
mechanism
need
be
explored.
Hence,
extracted
GqDNVs
from
fresh
berries
Lycium
barbarum
L.
(goji)
found
contents
are
rich
saccharides
lipids.
Based
on
pathway
annotations
predictions
non-targeted
metabolome
analysis,
tightly
associated
with
pathways
metabolism.
In
atrophy
model
mice,
intramuscular
injection
improves
cross-sectional
area
quadriceps
muscle,
grip
strength
AMPK/SIRT1/PGC1α
expression.
After
separately
inhibiting
AMPK
PGC1α
C2C12
cells
dexamethasone
administration,
activated
plays
chief
role
improving
cell
proliferation
induced
by
GqDNVs.
Furthermore,
energy-targeted
analysis
demonstrates
up-regulate
metabolism
amino
sugar
nucleotide
sugar,
autophagy
oxidative
phosphorylation
process,
which
indicates
activation
regeneration.
Besides,
Spearman
rank
shows
close
associations
between
quality
metabolites
expression
levels
SIRT1.
this
study,
provide
new
founding
accompanying
signaling
pathway.
Therefore,
anti-aging
potential
adjuvant
complementary
method
idea
future
therapy
research.
Graphical
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Июль 11, 2024
Background
Metabolic
dysfunction-associated
steatohepatitis
(MASH)
is
an
inflammatory
subtype
of
metabolic
steatotic
liver
disease
(MASLD)
has
recently
been
proposed
as
a
replacement
term
for
NAFLD,
common,
multifactorial
and
poorly
understood
whose
incidence
increasing
worldwide.
In
recent
years,
there
scientific
interest
in
exploring
the
relationship
between
gut
microbiota
MASH.
To
learn
more
about
MASH,
this
study
aims
to
provide
comprehensive
analysis
knowledge
structure
research
hotspots
from
bibliometric
perspective.
Methods
We
searched
Web
Science
Core
Collection
articles
reviews
that
covered
connections
MASH
over
last
decade.
The
Online
Analysis
Platforms,
VOSviewer,
CiteSpace,
R
tool
“bibliometrix”
were
used
analyzed
existing
publications
trends
hotspots.
Results
A
total
4,069
documents
related
interaction
retrieved
2014
2023.
number
annual
increased
significantly
decade,
particularly
United
States
China.
University
California-San
Diego
was
most
productive
institution,
while
researcher
Rohit
Loomba
published
papers
field.
Younossi
ZM
ranked
first
co-cited
author
largest
contributor
highly
cited
Gastroenterology
hepatology
common
specialty
category.
journal
decade
Hepatology.
Keyword
Bursts
highlighted
importance
studying
association
well
factors
such
syndrome,
insulin
resistance,
endotoxemia
overgrowth
bacteria.
clusters
with
co-citation
illustrate
important
topics
including
intestinal
permeability,
sensitivity
immunology.
keywords
include
obesity,
dysbiosis,
inflammation
oxidative
stress,
which
are
current
Conclusion
Our
highlights
key
aspects
field
emphasizes
multiorgan
crosstalk
MASLD/MASH
pathogenesis.
particular,
central
role
gut-liver
axis
significant
influence
dysbiosis
on
progression
highlighted.
Furthermore,
our
results
highlight
transformative
potential
microbiota-specific
therapies
cover
way
innovative
healthcare
pharmaceutical
strategies.
Nutrients,
Год журнала:
2024,
Номер
16(9), С. 1299 - 1299
Опубликована: Апрель 26, 2024
In
this
study,
the
influence
of
total
sn-2
palmitic
triacylglycerols
(TAGs)
and
ratio
1-oleoyl-2-palmitoyl-3-linoleoylglycerol
(OPL)
to
1,3-dioleoyl-2-palmitoylglycerol
(OPO)
in
human
milk
fat
substitute
(HMFS)
on
metabolic
changes
were
investigated
Sprague–Dawley
rats.
Metabolomics
lipidomics
profiling
analysis
indicated
that
increasing
TAGs
OPL
OPO
HMFS
could
significantly
glycine,
serine
threonine
metabolism,
glycerophospholipid
glycerolipid
sphingolipid
bile
acid
biosynthesis,
taurine
hypotaurine
metabolism
pathways
rats
after
4
weeks
feeding,
which
mainly
related
lipid,
energy
metabolism.
Meanwhile,
up-regulation
taurine,
L-tryptophan,
L-cysteine,
down-regulations
lysoPC
(18:0)
hypoxanthine
would
contribute
reduction
inflammatory
response
oxidative
stress,
improvement
immunity
function
addition,
targeted
biochemical
factors
also
revealed
HMFS-fed
had
increased
levels
anti-inflammatory
factor
(IL-4),
immunoglobulin
A
(IgA),
superoxide
dismutase
(SOD),
glutathione
peroxidase
(GSH-px),
decreased
pro-inflammatory
(IL-6
TNF-α)
malondialdehyde
(MDA),
compared
with
those
control
fat-fed
Collectively,
these
observations
present
new
vivo
nutritional
evidence
for
regulatory
effects
TAG
structure
composition
substitutes
host.
