Microbial transformations of bile acids and their receptors in the regulation of metabolic dysfunction-associated steatotic liver disease DOI Creative Commons
Yuhua Gao, Jun Lin, Chuan Ye

и другие.

Liver Research, Год журнала: 2023, Номер 7(3), С. 165 - 176

Опубликована: Сен. 1, 2023

Bile acids (BAs) play important roles in the digestion of dietary fats and molecular signal transduction, modulation BA composition usually affects progression metabolic diseases. While liver produces primary BAs, gut microbiota modifies these products into various forms that greatly increase their diversity biological functions. Mechanistically, BAs can regulate own metabolism transport as well other key aspects processes via dedicated receptors. Disruption homeostasis leads to diseases, including dysfunction-associated steatotic disease (MASLD) hepatocellular carcinoma (HCC). Here, we summarize microbial transformations downstream signaling development diseases present new insights novel therapeutic strategies targeting pathways may contribute

Язык: Английский

Gut symbionts alleviate MASH through a secondary bile acid biosynthetic pathway DOI Creative Commons
Qixing Nie, Xi Luo, Kai Wang

и другие.

Cell, Год журнала: 2024, Номер 187(11), С. 2717 - 2734.e33

Опубликована: Апрель 22, 2024

The gut microbiota has been found to play an important role in the progression of metabolic dysfunction-associated steatohepatitis (MASH), but mechanisms have not established. Here, by developing a click-chemistry-based enrichment strategy, we identified several microbial-derived bile acids, including previously uncharacterized 3-succinylated cholic acid (3-sucCA), which is negatively correlated with liver damage patients liver-tissue-biopsy-proven fatty disease (MAFLD). By screening human bacterial isolates, Bacteroides uniformis strains as effective producers 3-sucCA both vitro and vivo. activity-based protein purification identification, enzyme annotated β-lactamase B. responsible for biosynthesis. Furthermore, that lumen-restricted metabolite alleviates MASH promoting growth Akkermansia muciniphila. Together, our data offer new insights into microbiota-liver axis may be leveraged augment management MASH.

Язык: Английский

Процитировано

100

Glycine homeostasis requires reverse SHMT flux DOI Creative Commons
Matthew J. McBride,

Craig J Hunter,

Zhaoyue Zhang

и другие.

Cell Metabolism, Год журнала: 2024, Номер 36(1), С. 103 - 115.e4

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

21

Serine synthesis via reversed SHMT2 activity drives glycine depletion and acetaminophen hepatotoxicity in MASLD DOI Creative Commons
Alia Ghrayeb, Alexandra C Finney,

Bella Agranovich

и другие.

Cell Metabolism, Год журнала: 2024, Номер 36(1), С. 116 - 129.e7

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

18

Gouqi-derived nanovesicles (GqDNVs) inhibited dexamethasone-induced muscle atrophy associating with AMPK/SIRT1/PGC1α signaling pathway DOI Creative Commons
Xiaolei Zhou,

Shiyin Xu,

Zixuan Zhang

и другие.

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Май 22, 2024

Abstract With the increasing trend of global aging, sarcopenia has become a significant public health issue. Goji berry, also known as “Gou qi zi” in China, is traditional Chinese herb that can enhance structure and function muscles bones. Otherwise, previous excellent publications illustrated plant-derived exosome-like nanoparticles exert good bioactive functions different aging or disease models. Thus, we issued hypothesis Gouqi-derived nanovesicles (GqDNVs) may have ability to improve skeletal muscle health, though effect its mechanism need be explored. Hence, extracted GqDNVs from fresh berries Lycium barbarum L. (goji) found contents are rich saccharides lipids. Based on pathway annotations predictions non-targeted metabolome analysis, tightly associated with pathways metabolism. In atrophy model mice, intramuscular injection improves cross-sectional area quadriceps muscle, grip strength AMPK/SIRT1/PGC1α expression. After separately inhibiting AMPK PGC1α C2C12 cells dexamethasone administration, activated plays chief role improving cell proliferation induced by GqDNVs. Furthermore, energy-targeted analysis demonstrates up-regulate metabolism amino sugar nucleotide sugar, autophagy oxidative phosphorylation process, which indicates activation regeneration. Besides, Spearman rank shows close associations between quality metabolites expression levels SIRT1. this study, provide new founding accompanying signaling pathway. Therefore, anti-aging potential adjuvant complementary method idea future therapy research. Graphical

Язык: Английский

Процитировано

13

Amino Acid Metabolism and Atherosclerotic Cardiovascular Disease DOI Open Access
Sumit Kumar Anand, Theresea-Anne Governale, Xiangyu Zhang

и другие.

American Journal Of Pathology, Год журнала: 2024, Номер 194(4), С. 510 - 524

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

12

Epigenetics in metabolic dysfunction and steatohepatitis DOI
Yanru Zhang,

Ruike Ding,

Liangshuo Hu

и другие.

Cellular Signalling, Год журнала: 2025, Номер unknown, С. 111684 - 111684

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

1

EHBP1 suppresses liver fibrosis in metabolic dysfunction-associated steatohepatitis DOI
Fanglin Ma, Miriam Longo, Marica Meroni

и другие.

Cell Metabolism, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

1

Global research trends on gut microbiota and metabolic dysfunction-associated steatohepatitis: Insights from bibliometric and scientometric analysis DOI Creative Commons
Naqash Alam,

Linying Jia,

Ao Cheng

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Июль 11, 2024

Background Metabolic dysfunction-associated steatohepatitis (MASH) is an inflammatory subtype of metabolic steatotic liver disease (MASLD) has recently been proposed as a replacement term for NAFLD, common, multifactorial and poorly understood whose incidence increasing worldwide. In recent years, there scientific interest in exploring the relationship between gut microbiota MASH. To learn more about MASH, this study aims to provide comprehensive analysis knowledge structure research hotspots from bibliometric perspective. Methods We searched Web Science Core Collection articles reviews that covered connections MASH over last decade. The Online Analysis Platforms, VOSviewer, CiteSpace, R tool “bibliometrix” were used analyzed existing publications trends hotspots. Results A total 4,069 documents related interaction retrieved 2014 2023. number annual increased significantly decade, particularly United States China. University California-San Diego was most productive institution, while researcher Rohit Loomba published papers field. Younossi ZM ranked first co-cited author largest contributor highly cited Gastroenterology hepatology common specialty category. journal decade Hepatology. Keyword Bursts highlighted importance studying association well factors such syndrome, insulin resistance, endotoxemia overgrowth bacteria. clusters with co-citation illustrate important topics including intestinal permeability, sensitivity immunology. keywords include obesity, dysbiosis, inflammation oxidative stress, which are current Conclusion Our highlights key aspects field emphasizes multiorgan crosstalk MASLD/MASH pathogenesis. particular, central role gut-liver axis significant influence dysbiosis on progression highlighted. Furthermore, our results highlight transformative potential microbiota-specific therapies cover way innovative healthcare pharmaceutical strategies.

Язык: Английский

Процитировано

6

Effects of sn-2 Palmitic Triacylglycerols and the Ratio of OPL to OPO in Human Milk Fat Substitute on Metabolic Regulation in Sprague-Dawley Rats DOI Open Access
Lin Zhu, Shuaizhen Fang, Yaqiong Zhang

и другие.

Nutrients, Год журнала: 2024, Номер 16(9), С. 1299 - 1299

Опубликована: Апрель 26, 2024

In this study, the influence of total sn-2 palmitic triacylglycerols (TAGs) and ratio 1-oleoyl-2-palmitoyl-3-linoleoylglycerol (OPL) to 1,3-dioleoyl-2-palmitoylglycerol (OPO) in human milk fat substitute (HMFS) on metabolic changes were investigated Sprague–Dawley rats. Metabolomics lipidomics profiling analysis indicated that increasing TAGs OPL OPO HMFS could significantly glycine, serine threonine metabolism, glycerophospholipid glycerolipid sphingolipid bile acid biosynthesis, taurine hypotaurine metabolism pathways rats after 4 weeks feeding, which mainly related lipid, energy metabolism. Meanwhile, up-regulation taurine, L-tryptophan, L-cysteine, down-regulations lysoPC (18:0) hypoxanthine would contribute reduction inflammatory response oxidative stress, improvement immunity function addition, targeted biochemical factors also revealed HMFS-fed had increased levels anti-inflammatory factor (IL-4), immunoglobulin A (IgA), superoxide dismutase (SOD), glutathione peroxidase (GSH-px), decreased pro-inflammatory (IL-6 TNF-α) malondialdehyde (MDA), compared with those control fat-fed Collectively, these observations present new vivo nutritional evidence for regulatory effects TAG structure composition substitutes host.

Язык: Английский

Процитировано

5

Inhibition of hepatic oxalate overproduction ameliorates metabolic dysfunction-associated steatohepatitis DOI Creative Commons
Sandeep Das, Alexandra C Finney, Sumit Kumar Anand

и другие.

Nature Metabolism, Год журнала: 2024, Номер unknown

Опубликована: Сен. 27, 2024

Язык: Английский

Процитировано

5