Biochemical Society Transactions,
Год журнала:
2024,
Номер
52(4), С. 1647 - 1659
Опубликована: Авг. 23, 2024
Mitochondrial
respiration
is
major
source
of
chemical
energy
for
all
free-living
eukaryotes.
Nevertheless,
the
mechanisms
respiratory
complexes
and
supercomplexes
remain
poorly
understood.
Here,
I
review
recent
structural
functional
investigations
plant
supercomplex
+
III2
from
Arabidopsis
thaliana
Vigna
radiata.
discuss
commonalities,
open
questions
implications
complex
I,
in
plants
non-plants.
Studies
across
further
clades
will
enhance
our
understanding
potential
universal
its
supercomplexes.
Journal of Biological Chemistry,
Год журнала:
2024,
Номер
300(2), С. 105626 - 105626
Опубликована: Янв. 9, 2024
Mitochondrial
electron
transport
chain
complexes
organize
into
supramolecular
structures
called
respiratory
supercomplexes
(SCs).
The
role
of
SCs
remains
largely
unconfirmed
despite
evidence
supporting
their
necessity
for
mitochondrial
function.
mechanisms
underlying
the
formation
I
Viruses,
Год журнала:
2023,
Номер
15(12), С. 2380 - 2380
Опубликована: Дек. 4, 2023
Mitochondria
have
been
identified
as
the
“powerhouse”
of
cell,
generating
cellular
energy,
ATP,
for
almost
seven
decades.
Research
over
time
has
uncovered
a
multifaceted
role
mitochondrion
in
processes
such
stress
signaling,
precursor
molecules,
immune
response,
and
apoptosis
to
name
few.
Dysfunctional
mitochondria
resulting
from
departure
homeostasis
results
degeneration.
Viruses
hijack
host
cell
machinery
facilitate
their
own
replication
absence
bonafide
machinery.
Replication
being
an
energy
intensive
process
necessitates
regulation
oxidative
phosphorylation
occurring
at
electron
transport
chain
generate
energy.
Mitochondria,
therefore,
can
be
attractive
therapeutic
target
by
limiting
viral
replication.
In
this
review
we
focus
on
physiology
limited
studies
highlighting
regulatory
effects
viruses
induce
chain.
Trends in Cell Biology,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
While
mitochondrial
dysfunction
is
one
of
the
canonical
hallmarks
aging,
it
remains
only
vaguely
defined.
Its
core
feature
embraces
defects
in
energy-producing
molecular
machinery,
respiratory
complexes
(MRCs).
The
causes
and
consequences
these
hold
research
attention.
In
this
review,
we
assess
lifecycle
complexes,
from
biogenesis
to
degradation,
look
closely
at
mechanisms
that
could
underpin
their
aged
cells.
We
discuss
how
processes
be
altered
by
aging
expand
on
fate
MRCs
age-associated
pathologies.
Given
complexity
behind
MRC
maintenance
functionality,
several
traits
contribute
phenomenon
known
as
dysfunction.
New
advances
will
help
us
better
understand
machinery
age-related
diseases.
FASEB BioAdvances,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 15, 2025
ABSTRACT
Overexpression
of
spike
glycoprotein
G
vesicular
stomatitis
virus
(VSVG)
can
induce
the
release
fusogenic
plasma
membrane
vesicles
(fPMVs),
which
transport
cytoplasmic,
nuclear,
and
surface
proteins
directly
to
target
cells.
This
study
aimed
investigate
roles
rat
bone
marrow
mesenchymal
stem
cells
(rBMSCs)‐derived
fPMVs
containing
VSVG
protein
in
myocardial
injury
their
related
mechanisms.
The
plasmids
pLP‐VSVG
were
used
transfect
rBMSCs,
then
obtained
by
mechanical
extrusion.
After
that,
H9c2
first
treated
with
hypoxia
reoxygenation
(HR)
establish
a
cardiomyocyte
model,
evaluate
rescue
rBMSCs‐derived
on
HR‐induced
injury.
FPMVs
successfully
prepared
from
rBMSCs
overexpression.
Compared
control
fPMVs,
ACTB
,
HDAC1
VSVG,
CD81,
MTCO1,
TOMM20
significantly
up‐regulated
(
p
<
0.05),
while
eEF2
was
down‐regulated
0.05)
protein.
Additionally,
it
obvious
could
carry
mitochondria
into
cells,
HR
treatment
inhibited
viability
induced
apoptosis
as
well
increased
contents
TNF‐α
IL‐1β,
ROS
levels
both
cellular
mitochondria,
evidently
reducing
ATP,
MRCC
IV,
MT‐ND1
0.05).
However,
fPVMs
remarkably
reverse
changes
these
indexes
caused
RBMSCs‐derived
may
have
protective
effects
mediating
mitochondrial
transfer
regulating
functions.
Cellular and Molecular Neurobiology,
Год журнала:
2025,
Номер
45(1)
Опубликована: Апрель 21, 2025
Abstract
Aging
is
characterized
by
a
gradual
decline
in
physiological
functions,
with
brain
aging
being
major
risk
factor
for
numerous
neurodegenerative
diseases.
Given
the
brain’s
high
energy
demands,
maintaining
an
adequate
ATP
supply
crucial
its
proper
function.
However,
advancing
age,
mitochondria
dysfunction
and
deteriorating
metabolism
lead
to
reduced
overall
production
impaired
mitochondrial
quality
control
(MQC).
As
result,
promoting
healthy
has
become
key
focus
contemporary
research.
This
review
examines
relationship
between
aging,
highlighting
connection
MQC
metabolism,
proposes
strategies
delay
targeting
metabolism.
