Chemical Engineering Journal, Год журнала: 2024, Номер unknown, С. 159079 - 159079
Опубликована: Дек. 1, 2024
Язык: Английский
The Innovation Life, Год журнала: 2024, Номер 2(3), С. 100078 - 100078
Опубликована: Янв. 1, 2024
<p>Bone is a mineralized tissue that provides fundamental support for body posture and biomechanical forces. Bones have also been meticulously used by humans as fine tools at least over 25,000 years, perpetually captivating our curiosity driving exploration into its mysteries. In this perspective, we revisit the milestones in history of bone biology since 17<sup>th</sup> century, highlighted transformative impact pioneering technologies. From macroanatomical observations to microscopic cellular analyses molecular signaling pathway explorations, each milestone has heralded groundbreaking discoveries. These include elucidation Wollf’s Law, regulatory mechanisms calcium metabolism (via osteotropic parathyroid hormone analogs calcitonin), well revelation critical cell interactions pathways remodeling. foundational insights deepen understanding an enigmatic underexplored tissue, but yield significant clinical advancements. Bone stands poised explosive expansion knowledge usher era systems biology, propelled cutting-edge multi-omics approaches, including single RNA sequencing (scRNA-seq) spatial transcriptomics, artificial intelligence. Therefore, challenges future directions are discussed navigate complexities integrating emerging technologies foster interdisciplinary collaborations will propel research towards innovative breakthroughs holistic solutions.</p>
Язык: Английский
Процитировано
9
Nature Reviews Endocrinology, Год журнала: 2025, Номер unknown
Опубликована: Фев. 26, 2025
Язык: Английский
Процитировано
1
Bone Research, Год журнала: 2025, Номер 13(1)
Опубликована: Март 17, 2025
Abstract Following the discovery of bone as an endocrine organ with systemic influence, bone-brain interaction has emerged a research hotspot, unveiling complex bidirectional communication between and brain. Studies indicate that brain can influence each other’s homeostasis via multiple pathways, yet there is dearth systematic reviews in this area. This review comprehensively examines interactions across three key areas: bone-derived factors on function, effects brain-related diseases or injuries (BRDI) health, concept skeletal interoception. Additionally, discusses innovative approaches biomaterial design inspired by mechanisms, aiming to facilitate through materiobiological aid treatment neurodegenerative bone-related diseases. Notably, integration artificial intelligence (AI) highlighted, showcasing AI’s role expediting formulation effective targeted strategies. In conclusion, offers vital insights into mechanisms suggests advanced harness these clinical practice. These offer promising avenues for preventing treating impacting skeleton brain, underscoring potential interdisciplinary enhancing human health.
Язык: Английский
Процитировано
1
Journal of Orthopaedic Translation, Год журнала: 2024, Номер 48, С. 217 - 231
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
6
Current Obesity Reports, Год журнала: 2024, Номер unknown
Опубликована: Сен. 3, 2024
Язык: Английский
Процитировано
4
Journal of Orthopaedic Surgery and Research, Год журнала: 2025, Номер 20(1)
Опубликована: Янв. 18, 2025
After spinal cord injury (SCI), mechanical unloading, denervation, as well negative changes in blood supply, inflammation state, and hormone levels produce significant effects on bone density, leading to a high prevalence of osteoporosis after SCI. It has been recently discovered that skeletal also endocrine functions. Osteokines, secreted from tissue, could play multiple roles regulating muscle mass, glucose metabolism, functions the central nervous system-changes osteokine SCI have detected. Therefore, density should be stressed clinical settings. Clinical treatment measures for loss include exercise training, physical agent therapy, acupuncture, so on. According previous studies, these treatments affect expression osteokines. In conclusion, osteokines are worthy great attention during rehabilitation Osteokines become biomarkers rehabilitation, reflecting both systemic This review summarized recent findings regarding SCI, osteokines, effect therapies, with particular emphasis local regulatory their potential rehabilitation.
Язык: Английский
Процитировано
0
PLoS ONE, Год журнала: 2025, Номер 20(2), С. e0316708 - e0316708
Опубликована: Фев. 7, 2025
Alzheimer's disease (AD) and Osteoarthritis (OA) have been shown to a close association in previous studies, but the pathogenesis of both diseases are unclear. This study explores potential common molecular mechanisms between AD OA through bioinformatics analysis, providing new insights for clinical treatment strategies. The OA-related datasets were downloaded from gene expression database GEO. analyzed obtain differentially expressed (DEG) AD, respectively. intersection these DEGs was identify (Co-DEGs). Subsequently, Co-DEGs enriched, protein-protein interaction network constructed core genes. genes validated separate dataset, their diagnostic value analyzed. In addition, using set enrichment analysis single-gene genome variation analysis. Analysis on chips patients revealed significant changes patterns. Notably, EFEMP2 TSPO, associated with inflammatory responses, showed lower levels patients, suggesting downregulation pathological backgrounds diseases. Additionally, GABARAPL1, which is crucial maturation autophagosomes, found be upregulated conditions. These findings suggest as biomarkers therapeutic targets. However, confirm effectiveness targets, more in-depth mechanistic studies needed future, particularly explore feasibility specific combating progression by regulating suggests that shares mechanisms. identification EFEMP2, TSPO key target highlights factors Further investigation into could lead candidate targets directions OA, offering promising avenues developing effective targeted interventions.
Язык: Английский
Процитировано
0
Biomolecules, Год журнала: 2025, Номер 15(3), С. 331 - 331
Опубликована: Фев. 25, 2025
Both diabetes and osteoporosis are serious chronic conditions. Evidence is mounting that several bone-derived hormones play a role in glucose metabolism patients with diabetes. Notably, novel biotargeted anti-osteoporotic agents have been recently found to reduce the risk of This review explores correlation osteokines, including receptor activator nuclear factor-κB ligand (RANKL), sclerostin, Dickkopf-1 (DKK1) glycemic indicators diabetes, as well effects their respective monoclonal antibodies on possible mechanisms. Denosumab, antibody against RANKL, has shown glycated hemoglobin (HbA1c) possibly by enhancing pancreatic β-cell survival glucagon-like peptide-1 secretion. Sclerostin was positively correlated HbA1c may induce insulin resistance via endoplasmic reticulum stress. The association DKK1 fasting plasma still unclear, though decreasing levels correlate survival. However, few studies investigated sclerostin or metabolism. Further research required elucidate influence homeostasis underlying
Язык: Английский
Процитировано
0
iScience, Год журнала: 2025, Номер 28(4), С. 112177 - 112177
Опубликована: Март 7, 2025
Chemokine C-C motif ligand 7 (CCL7) is implicated in various immune and inflammatory processes; however, its role rheumatoid arthritis (RA) remains unclear. In this study, we observed that CCL7 expression was upregulated synovial M1-polarized macrophages the serum of RA mice patients. found to promote macrophage polarization toward M1 phenotype while inhibiting M2 differentiation vitro. Furthermore, intra-articular injection recombinant protein resulted enhanced polarization, increased inflammation, fibrosis within tissues, which exacerbated arthritis-associated pain. These effects were partially mitigated by treatment with a neutralizing antibody. Mechanistically, identified autocrine positive feedback loop amplifies inflammation via CCL7-CCR1-JAK2/STAT1 pathway. Collectively, our findings reveal previously unrecognized CCL7-mediated amplification modulates exacerbates progression, positioning as potential therapeutic target for RA.
Язык: Английский
Процитировано
0
Bone Research, Год журнала: 2025, Номер 13(1)
Опубликована: Март 26, 2025
Язык: Английский
Процитировано
0