Cancer associated fibroblasts and metabolic reprogramming: unraveling the intricate crosstalk in tumor evolution

Journal of Hematology & Oncology, Год журнала: 2024, Номер 17(1)

Опубликована: Сен. 2, 2024

Metabolic reprogramming provides tumors with an energy source and biofuel to support their survival in the malignant microenvironment. Extensive research into intrinsic oncogenic mechanisms of tumor microenvironment (TME) has established that cancer-associated fibroblast (CAFs) metabolic regulates progression through numerous biological activities, including immunosuppression, chronic inflammation, ecological niche remodeling. Specifically, immunosuppressive TME formation is promoted mediators released via CAFs multiple immune cells collectively thereby inducing pre-metastatic formation, ultimately driving a vicious cycle proliferation metastasis. This review comprehensively explores process regulation dynamic evolution tumor-adapted TME, particular focus on by which promote Existing findings confirm components act cooperatively accelerate events. The potential applications challenges targeted therapies based clinical setting are further discussed context advancing related CAFs.

Язык: Английский

---

Tissue macrophages: origin, heterogenity, biological functions, diseases and therapeutic targets

Signal Transduction and Targeted Therapy, Год журнала: 2025, Номер 10(1)

Опубликована: Март 7, 2025

Abstract Macrophages are immune cells belonging to the mononuclear phagocyte system. They play crucial roles in defense, surveillance, and homeostasis. This review systematically discusses types of hematopoietic progenitors that give rise macrophages, including primitive progenitors, erythro-myeloid stem cells. These have distinct genetic backgrounds developmental processes. Accordingly, macrophages exhibit complex diverse functions body, phagocytosis clearance cellular debris, antigen presentation, response, regulation inflammation cytokine production, tissue remodeling repair, multi-level regulatory signaling pathways/crosstalk involved homeostasis physiology. Besides, tumor-associated a key component TME, exhibiting both anti-tumor pro-tumor properties. Furthermore, functional status is closely linked development various diseases, cancer, autoimmune disorders, cardiovascular disease, neurodegenerative metabolic conditions, trauma. Targeting has emerged as promising therapeutic strategy these contexts. Clinical trials macrophage-based targeted drugs, immunotherapies, nanoparticle-based therapy were comprehensively summarized. Potential challenges future directions targeting also been discussed. Overall, our highlights significance this versatile cell human health which expected inform research clinical practice.

Язык: Английский

---

The RIG-I-like receptor signaling pathway triggered by Staphylococcus aureus promotes breast cancer metastasis

International Immunopharmacology, Год журнала: 2024, Номер 142, С. 113195 - 113195

Опубликована: Сен. 20, 2024

Язык: Английский

---

Arginine Metabolism Reprogramming in Perfluorooctanoic Acid (PFOA)-Induced Liver Injury

Environmental Science & Technology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 10, 2025

Perfluorooctanoic acid (PFOA) is a persistent pollutant that has gained worldwide attention, owing to its widespread presence in the environment. Previous studies have reported PFOA upregulates lipid metabolism and associated with liver injury humans. However, when fatty degradation pathway activated, accumulation still occurs, suggesting of unknown pathways mechanisms remain be elucidated. In this study, adult C57BL/6N mice were exposed at 0.1, 1, 10 mg/kg/day. Using integrated metabolomics transcriptomics, it was uncovered arginine differentially downregulated all three groups. vitro confirmed downregulation MIHA cell lines treated PFOA. Supplementation could effectively rescue downregulate chemokine levels caused by This finding highlights contribution maintaining health following exposure suggests potential metabolic immune modulation.

Язык: Английский

---

Predictive biomarkers for immunotherapy in gastric cancer

Journal of Cancer Metastasis and Treatment, Год журнала: 2025, Номер unknown

Опубликована: Март 21, 2025

Gastric cancer remains a significant global health burden, and while immunotherapy offers promising therapeutic avenues, its efficacy varies greatly among patients. The key challenge is accurately identifying treatment responders, alternative strategies are necessary for non-responders. Biomarkers such as PD-L1 expression, tumor mutational mismatch repair status, Epstein-Barr virus infection have shown predictive potential, yet the quest more reliable markers continues to be challenging. Emerging technologies, including liquid biopsy, single-cell sequencing, artificial intelligence, present novel approaches enhancing individualized research improving capabilities. This review provides comprehensive analysis of current biomarkers introduces emerging candidates from recent studies, thereby contributing ongoing efforts refine patient stratification strategies.

Язык: Английский

---

Analysis of Tryptophan Metabolic Profile Characteristics and Clinical Value in Differentiated Thyroid Cancer Patients

Cancer Medicine, Год журнала: 2025, Номер 14(6)

Опубликована: Март 1, 2025

ABSTRACT Background Differentiated thyroid cancer (DTC) is the primary subtype of cancer. Timely diagnosis and intervention are crucial for improving prognosis survival. However, effectiveness existing serum markers limited, necessitating discovery new biomarkers. Methods This study utilized liquid chromatography–tandem mass spectrometry to analyze tryptophan metabolic profiles in samples from 105 DTC patients 50 healthy controls. Independent predictors were identified through univariate intergroup comparisons multivariate logistic regression analysis, leading development validation a diagnostic model. Results Significant differences observed 11 metabolites between Logistic nicotinamide, 3‐hydroxyanthranilic acid, 5‐hydroxytryptophan, melatonin, indole‐3‐propionic acid as independent predictors. The nomogram prediction model was established based on these five metabolites, according Hosmer–Lemeshow test, showed good fit. five‐metabolite demonstrated 84.8% sensitivity, 90.0% specificity, an area under ROC curve 0.932. Decision analysis indicated that had significant advantages over thyroglobulin. Discussion Tryptophan metabolism exhibits distinct changes patients, with specific serving early markers. panel demonstrates potential detection management DTC.

Язык: Английский

---

Cancer associated fibroblasts in cancer development and therapy

Journal of Hematology & Oncology, Год журнала: 2025, Номер 18(1)

Опубликована: Март 28, 2025

Cancer-associated fibroblasts (CAFs) are key players in cancer development and therapy, they exhibit multifaceted roles the tumor microenvironment (TME). From their diverse cellular origins, CAFs undergo phenotypic functional transformation upon interacting with cells presence can adversely influence treatment outcomes severity of cancer. Emerging evidence from single-cell RNA sequencing (scRNA-seq) studies have highlighted heterogeneity plasticity CAFs, subtypes identifiable through distinct gene expression profiles properties. multiple mechanisms, including regulation extracellular matrix (ECM) remodeling, direct promotion growth provision metabolic support, promoting epithelial-mesenchymal transition (EMT) to enhance invasiveness growth, as well stimulating stem cell properties within tumor. Moreover, induce an immunosuppressive TME contribute therapeutic resistance. In this review, we summarize fundamental knowledge recent advances regarding focusing on sophisticated potential targets. We discuss various strategies target ECM modulation, elimination, interruption CAF-TME crosstalk, CAF normalization, approaches developing more effective treatments. An improved understanding complex interplay between is crucial for new targeted therapies

Язык: Английский

---

Butyrate-engineered yeast activates Nppa and Sgcg genes and reduces radiation-induced heart damage via the gut-heart axis

Pharmacological Research, Год журнала: 2025, Номер unknown, С. 107642 - 107642

Опубликована: Фев. 1, 2025

Radiotherapy is a method of treating cancer through radiation aimed at killing cells or inhibiting their growth. However, radiotherapy has numerous side effects because it kills tumors while causing damage to normal tissues. The literature shows that can cause heart tissue. This study found engineered yeast produced butyrate maintain small intestinal barrier function by recovering GPR109A reduce caused abdominal irradiation in mice. We unexpectedly could mitigate irradiation-induced via the gut-heart axis. Mechanistically, enhanced taurine and nicotinamide metabolism increasing relative abundance Akkermansia Lachnospiraceae_NK4A136; then, modulated cardiac activating Sgcg Nppa genes attenuate induced irradiation. Finally, we confirmed mitigated total body irradiation, which protected other vital organs tract. profound impact on treatment, emergence will alleviate benefit patients.

Язык: Английский

---

Targeting amino acid metabolism to inhibit gastric cancer progression and promote anti-tumor immunity: a review

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Фев. 13, 2025

The incidence of gastric cancer remains high and poses a serious threat to human health. Recent comprehensive investigations into amino acid metabolism immune system components within the tumor microenvironment have elucidated functional interactions between cells, metabolism. This study reviews characteristics in cancer, with particular focus on methionine, cysteine, glutamic acid, serine, taurine, other acids. It discusses relationship these metabolic processes, development, body’s anti-tumor immunity, analyzes importance targeting for chemotherapy immunotherapy.

Язык: Английский

---

NLRP4 unlocks an NK/macrophages-centered ecosystem to suppress non-small cell lung cancer

Biomarker Research, Год журнала: 2025, Номер 13(1)

Опубликована: Март 14, 2025

Abstract Background Tumor immune evasion extends beyond T cells, affecting innate elements like natural killer cells (NK) and macrophages within the tumor-immune microenvironment (TIME). Nevertheless, translational strategies to trigger collaboration of NK initiate sufficient anti-tumor cytoxicity remain scarce are urgently needed. Methods In this study, TCGA datasets was used confirm prognosis value expression level NLR family pyrin domain containing 4 (NLRP4) in NSCLC tumor tissues microarray further check its clinical-relevance at protein-level. Subsequently, a cell line with stable NLRP4 overexpression established subcutaneous models C57BL/6J mice were validate characteristics NLRP4. After analyzing using flow cytometry multiplex immunofluorescence, we validated our findings through co-culture transwell assays analysis. Utilizing bulk-RNA sequencing, proteomics, mass spectrometry mouse tissues, innovatively identified downstream pathways verified them co-immunoprecipitation (co-IP) Western blot (WB) experiments. Results could distinct ecosystem organized by TIGIT + TNFA iNOS M1 lung cancer, discovered analysis murine model. NLRP4-eco exerted tumor-suppression capacity chemokine reprogramming including CCL5 CXCL2. Meanwhile, be facilitated M1. Mechanistically, stimulated PI3K/Akt-NF-kB axis suppression activity PP2A. Besides, knockdown blockade CXCL2-CXCR2 abolished chemotaxis respectively, as well for LB-100, PP2A inhibitor. Conclusion Altogether, delineated NLRP4’s unexplored facets an NLRP4-driven composed Finally, targeting inhibitor successfully mimicked

Язык: Английский

---