Nanotherapeutic strategies exploiting biological traits of cancer stem cells

Bioactive Materials, Год журнала: 2025, Номер 50, С. 61 - 94

Опубликована: Апрель 6, 2025

Язык: Английский

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Tumor Microenvironment Lactate: Is It a Cancer Progression Marker, Immunosuppressant, and Therapeutic Target?

Molecules, Год журнала: 2025, Номер 30(8), С. 1763 - 1763

Опубликована: Апрель 15, 2025

The “Warburg effect” is a term coined century ago for the preferential use of glycolysis over aerobic respiration in tumor cells energy production, even under conditions. Although this less efficient mechanism generating from glucose, glycolysis, addition to canonical anaerobic an effective means lactate production. abundant waste product, lactate, yielded by dual tumor, has been discovered be major biomolecule that drives cancer progression. Lactate metabolic source that, via cell membrane transporters, shuttles and out as well cell-associated stromal immune within microenvironment (TME). Additionally, serves pH tuner, signaling ligand transducer, epigenetic gene transcription regulator, TME modifier, suppressor, chemoresistance modulator, prognostic marker. With such broad functionalities, production–consumption–reproduction fuels growth dissemination. Here, we elaborate on sources contribute pool TME, functions influence function local tissue immunity, anticancer therapeutic approaches adopting manipulations their efficacies. By scrutinizing these properties others have addressed field, it expected better weighing development, progression, prognosis, efficacy can achieved.

Язык: Английский

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Targeting metzincins to mitigate jellyfish blooms: a novel approach for conservation

Frontiers in Marine Science, Год журнала: 2025, Номер 12

Опубликована: Апрель 15, 2025

Introduction The modification of the marine ecological environment has led to frequent occurrence jellyfish blooms, causing global hazards. budding reproduction polyps is a critical factor in their population size, yet there limited understanding molecular mechanisms involved this process. This study aims explore intrinsic regulatory factors Aurelia coerulea ( A. ) from perspective biotoxin and develop new strategies for management abundance. Methods main biological toxins polyp were screened through integrated analysis transcriptomic proteomic data. broad-spectrum metalloproteinase inhibitor, ethylenediaminetetraacetic acid (EDTA), was employed treat observing its effect on polyps. Through conducting detection metzincin proteolytic activity, docking kinetic analysis, as well RT-qPCR verification before after EDTA treatment polyp, key influencing clarified. Results Four types family metalloproteinases constituted biotoxins polyp. Among them, astacins (NAS) predominant metzincins We discovered that significantly inhibited activity capable stably binding zinc-binding active sites four major could down-regulate expression levels molecules enrich multiple pathways related development. Conclusion elucidates effects polyps, providing potential target mitigating blooms.

Язык: Английский

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Research progress on the regulatory role of lactate and lactylation in tumor microenvironment

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Год журнала: 2025, Номер unknown, С. 189339 - 189339

Опубликована: Апрель 1, 2025

Язык: Английский

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Signaling switches: Metabolism regulates gastruloid self-organization

Cell stem cell, Год журнала: 2025, Номер 32(5), С. 673 - 675

Опубликована: Май 1, 2025

Язык: Английский

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