Cell stem cell, Год журнала: 2025, Номер 32(5), С. 673 - 675
Опубликована: Май 1, 2025
Язык: Английский
Cell stem cell, Год журнала: 2025, Номер 32(5), С. 673 - 675
Опубликована: Май 1, 2025
Язык: Английский
Bioactive Materials, Год журнала: 2025, Номер 50, С. 61 - 94
Опубликована: Апрель 6, 2025
Язык: Английский
Процитировано
0Molecules, Год журнала: 2025, Номер 30(8), С. 1763 - 1763
Опубликована: Апрель 15, 2025
The “Warburg effect” is a term coined century ago for the preferential use of glycolysis over aerobic respiration in tumor cells energy production, even under conditions. Although this less efficient mechanism generating from glucose, glycolysis, addition to canonical anaerobic an effective means lactate production. abundant waste product, lactate, yielded by dual tumor, has been discovered be major biomolecule that drives cancer progression. Lactate metabolic source that, via cell membrane transporters, shuttles and out as well cell-associated stromal immune within microenvironment (TME). Additionally, serves pH tuner, signaling ligand transducer, epigenetic gene transcription regulator, TME modifier, suppressor, chemoresistance modulator, prognostic marker. With such broad functionalities, production–consumption–reproduction fuels growth dissemination. Here, we elaborate on sources contribute pool TME, functions influence function local tissue immunity, anticancer therapeutic approaches adopting manipulations their efficacies. By scrutinizing these properties others have addressed field, it expected better weighing development, progression, prognosis, efficacy can achieved.
Язык: Английский
Процитировано
0Frontiers in Marine Science, Год журнала: 2025, Номер 12
Опубликована: Апрель 15, 2025
Introduction The modification of the marine ecological environment has led to frequent occurrence jellyfish blooms, causing global hazards. budding reproduction polyps is a critical factor in their population size, yet there limited understanding molecular mechanisms involved this process. This study aims explore intrinsic regulatory factors Aurelia coerulea ( A. ) from perspective biotoxin and develop new strategies for management abundance. Methods main biological toxins polyp were screened through integrated analysis transcriptomic proteomic data. broad-spectrum metalloproteinase inhibitor, ethylenediaminetetraacetic acid (EDTA), was employed treat observing its effect on polyps. Through conducting detection metzincin proteolytic activity, docking kinetic analysis, as well RT-qPCR verification before after EDTA treatment polyp, key influencing clarified. Results Four types family metalloproteinases constituted biotoxins polyp. Among them, astacins (NAS) predominant metzincins We discovered that significantly inhibited activity capable stably binding zinc-binding active sites four major could down-regulate expression levels molecules enrich multiple pathways related development. Conclusion elucidates effects polyps, providing potential target mitigating blooms.
Язык: Английский
Процитировано
0Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Год журнала: 2025, Номер unknown, С. 189339 - 189339
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0Cell stem cell, Год журнала: 2025, Номер 32(5), С. 673 - 675
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
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