Research progress on the regulatory role of lactate and lactylation in tumor microenvironment
Chunyan Gao,
No information about this author
Jiali Li,
No information about this author
Baoen Shan
No information about this author
et al.
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer,
Journal Year:
2025,
Volume and Issue:
unknown, P. 189339 - 189339
Published: April 1, 2025
Language: Английский
Signaling switches: Metabolism regulates gastruloid self-organization
Cell stem cell,
Journal Year:
2025,
Volume and Issue:
32(5), P. 673 - 675
Published: May 1, 2025
Language: Английский
Nanotherapeutic strategies exploiting biological traits of cancer stem cells
Bioactive Materials,
Journal Year:
2025,
Volume and Issue:
50, P. 61 - 94
Published: April 6, 2025
Language: Английский
Tumor Microenvironment Lactate: Is It a Cancer Progression Marker, Immunosuppressant, and Therapeutic Target?
Eugene Y. Kim,
No information about this author
Joyce Abides,
No information about this author
Chandler R. Keller
No information about this author
et al.
Molecules,
Journal Year:
2025,
Volume and Issue:
30(8), P. 1763 - 1763
Published: April 15, 2025
The
“Warburg
effect”
is
a
term
coined
century
ago
for
the
preferential
use
of
glycolysis
over
aerobic
respiration
in
tumor
cells
energy
production,
even
under
conditions.
Although
this
less
efficient
mechanism
generating
from
glucose,
glycolysis,
addition
to
canonical
anaerobic
an
effective
means
lactate
production.
abundant
waste
product,
lactate,
yielded
by
dual
tumor,
has
been
discovered
be
major
biomolecule
that
drives
cancer
progression.
Lactate
metabolic
source
that,
via
cell
membrane
transporters,
shuttles
and
out
as
well
cell-associated
stromal
immune
within
microenvironment
(TME).
Additionally,
serves
pH
tuner,
signaling
ligand
transducer,
epigenetic
gene
transcription
regulator,
TME
modifier,
suppressor,
chemoresistance
modulator,
prognostic
marker.
With
such
broad
functionalities,
production–consumption–reproduction
fuels
growth
dissemination.
Here,
we
elaborate
on
sources
contribute
pool
TME,
functions
influence
function
local
tissue
immunity,
anticancer
therapeutic
approaches
adopting
manipulations
their
efficacies.
By
scrutinizing
these
properties
others
have
addressed
field,
it
expected
better
weighing
development,
progression,
prognosis,
efficacy
can
achieved.
Language: Английский
Targeting metzincins to mitigate jellyfish blooms: a novel approach for conservation
Xuecun Liu,
No information about this author
Xiao Peng,
No information about this author
Jingqiang Wang
No information about this author
et al.
Frontiers in Marine Science,
Journal Year:
2025,
Volume and Issue:
12
Published: April 15, 2025
Introduction
The
modification
of
the
marine
ecological
environment
has
led
to
frequent
occurrence
jellyfish
blooms,
causing
global
hazards.
budding
reproduction
polyps
is
a
critical
factor
in
their
population
size,
yet
there
limited
understanding
molecular
mechanisms
involved
this
process.
This
study
aims
explore
intrinsic
regulatory
factors
Aurelia
coerulea
(
A.
)
from
perspective
biotoxin
and
develop
new
strategies
for
management
abundance.
Methods
main
biological
toxins
polyp
were
screened
through
integrated
analysis
transcriptomic
proteomic
data.
broad-spectrum
metalloproteinase
inhibitor,
ethylenediaminetetraacetic
acid
(EDTA),
was
employed
treat
observing
its
effect
on
polyps.
Through
conducting
detection
metzincin
proteolytic
activity,
docking
kinetic
analysis,
as
well
RT-qPCR
verification
before
after
EDTA
treatment
polyp,
key
influencing
clarified.
Results
Four
types
family
metalloproteinases
constituted
biotoxins
polyp.
Among
them,
astacins
(NAS)
predominant
metzincins
We
discovered
that
significantly
inhibited
activity
capable
stably
binding
zinc-binding
active
sites
four
major
could
down-regulate
expression
levels
molecules
enrich
multiple
pathways
related
development.
Conclusion
elucidates
effects
polyps,
providing
potential
target
mitigating
blooms.
Language: Английский