Frontiers in Public Health,
Год журнала:
2023,
Номер
11
Опубликована: Март 14, 2023
Background
Increased
rates
of
methicillin-resistant
Staphylococcus
aureus
(MRSA)
antibiotic
resistance
and
the
associated
morbidity
have
increased
dermatologists'
attention
to
skin
soft
tissue
MRSA
infections.
However,
clinical
characterization
infections
(SSTIs)
in
Southwest
China
is
lacking,
which
precludes
optimal
prevention
treatment
these
Objectives
This
study
was
conducted
characterize
prevalence,
comorbidities
susceptibility
isolates
from
SSTIs,
including
community-associated
(CA)
healthcare-associated
(HA)
isolates.
Methods
In
Dermatology
Inpatient
Department
First
Affiliated
Hospital
Guangxi
Medical
University,
a
retrospective
on
data,
patient
demographics
information,
culture-confirmed
S.
isolated
between
January
1,
2015,
December
31,
2021.
Isolate
13
antibiotics
determined
using
Vitek
2
system.
Results
From
among
864
strains,
we
identified
283
(32.75%)
comprising
203
CA-MRSA
80
HA-MRSA
The
average
rate
isolation
for
SSTIs
71.73%.
significantly.
HA-MRSA-infected
patients
were
older.
most
common
dermatological
presentation
infection
staphylococcal
scalded
syndrome,
while
comorbidity
severe
drug
eruption
significantly
with
infection.
One
strain
resistant
linezolid,
one
had
an
intermediate
phenotype
vancomycin;
both
strains
low
sensitivity
clindamycin
erythromycin
(3.70%~19.40%).
more
susceptible
trimethoprim/sulfamethoxazole.
Conclusions
predominant
pathogen
causing
incidence
increasing
gradually.
Both
showed
resistance.
Our
data
may
guide
dermatologist
decisions.
Dermatologists
should
consider
when
are
admitted
initiate
early
MRSA.
Antibiotics,
Год журнала:
2022,
Номер
11(4), С. 535 - 535
Опубликована: Апрель 18, 2022
The
spread
of
COVID-19
pandemic
may
have
affected
antibiotic
consumption
patterns
and
the
prevalence
colonized
or
infected
by
multidrug-resistant
(MDR)
bacteria.
We
investigated
differences
in
antibiotics
easily
prone
to
resistance
MDR
bacteria
during
(March
2020
September
2021)
compared
pre-pandemic
period
2018
2019).
Data
on
usage
infections
caused
methicillin-resistant
Staphylococcus
aureus
(MRSA),
vancomycin-resistant
Enterococcus
(VRE),
carbapenem-resistant
Enterobacteriaceae
(CRE),
Acinetobacter
baumannii
(CRAB),
Pseudomonas
aeruginosa
(CRPA)
were
obtained
from
hospitalized
patients
four
university
hospitals.
penicillin
with
β-lactamase
inhibitors
(3.4%
ward,
5.8%
intensive
care
unit
(ICU)),
carbapenems
(25.9%
12.1%
ICU)
increased
period.
MRSA
(4.7%),
VRE
(49.0%),
CRE
(22.4%),
CRPA
(20.1%)
isolated
clinical
samples
ward
(26.7%)
(36.4%)
ICU
significantly
increased,
respectively.
Meanwhile,
only
(38.7%)
surveillance
increased.
is
associated
has
influenced
isolates.
Emerging infectious diseases,
Год журнала:
2022,
Номер
28(11), С. 1 - 8
Опубликована: Окт. 26, 2022
During
2020-2021,
countries
in
Latin
America
and
the
Caribbean
reported
clinical
emergence
of
carbapenemase-producing
Enterobacterales
that
had
not
been
previously
characterized
locally,
increased
prevalence
carbapenemases
detected,
co-production
multiple
some
isolates.
These
increases
were
likely
fueled
by
changes
related
to
COVID-19
pandemic,
including
empirical
antibiotic
use
for
potential
COVID-19-related
bacterial
infections
healthcare
limitations
resulting
from
rapid
rise
cases.
Strengthening
antimicrobial
resistance
surveillance,
epidemiologic
research,
infection
prevention
control
programs
stewardship
settings
can
help
prevent
transmission
Enterobacterales.
Abstract
Background
The
study
aimed
to
describe
the
epidemiology
and
outcomes
of
hospital-acquired
bloodstream
infections
(HABSIs)
between
COVID-19
non-COVID-19
critically
ill
patients.
Methods
We
used
data
from
Eurobact
II
study,
a
prospective
observational
multicontinental
cohort
on
HABSI
treated
in
ICU.
For
current
analysis,
we
selected
centers
that
included
both
performed
descriptive
statistics
terms
patients’
characteristics,
source
infection
microorganism
distribution.
studied
association
status
mortality
using
multivariable
fragility
Cox
models.
Results
A
total
53
19
countries
over
5
continents
were
eligible.
Overall,
829
patients
(median
age
65
years
[IQR
55;
74];
male,
n
=
538
[64.9%])
for
HABSI.
Included
comprised
252
(30.4%)
577
(69.6%)
time
interval
hospital
admission
was
similar
groups.
Respiratory
sources
(40.1
vs.
26.0%,
p
<
0.0001)
primary
(25.4%
17.2%,
0.006)
more
frequent
had
often
enterococcal
(20.5%
9%)
Acinetobacter
spp.
(18.8%
13.6%)
HABSIs.
Bacteremic
an
increased
hazard
ratio
(HR)
versus
(HR
1.91,
95%
CI
1.49–2.45).
Conclusions
showed
differed
Enterococcal
predominated
with
elevated
risk
mortality.
Trial
registration
ClinicalTrials.org
number
NCT03937245
.
Registered
3
May
2019.
Pathogens,
Год журнала:
2023,
Номер
12(5), С. 743 - 743
Опубликована: Май 22, 2023
The
ESKAPE
group
constitute
a
threat
to
public
health,
since
these
microorganisms
are
associated
with
severe
infections
in
hospitals
and
have
direct
relationship
high
mortality
rates.
presence
of
bacteria
had
impact
on
the
incidence
healthcare-associated
coinfections
SARS-CoV-2
pandemic.
In
recent
years,
pathogens
shown
resistance
multiple
antibiotic
families.
high-risk
clones
within
this
contributes
spread
mechanisms
worldwide.
pandemic,
were
implicated
severely
ill
COVID-19
patients.
aim
review
is
describe
main
involved
patients,
addressing
mainly
antimicrobial
mechanisms,
epidemiology,
clones.
Journal for ImmunoTherapy of Cancer,
Год журнала:
2025,
Номер
13(4), С. e011200 - e011200
Опубликована: Апрель 1, 2025
Background
The
risk
of
secondary
primary
malignancies
(SPMs)
associated
with
bispecific
antibody
(BsAb)—a
promising
alternative
to
chimeric
antigen
receptor
(CAR)-T
therapy—remains
insufficiently
explored.
Methods
Using
large-scale,
real-world
data
from
the
US
Food
and
Drug
Administration’s
Adverse
Event
Reporting
System,
we
identified
relative
frequency
characteristics
SPMs
following
BsAbs
therapy
conducted
a
comprehensive
comparison
treatment-related
SPM
profiles
between
CAR-T
therapies.
Results
We
108
cases
among
10,280
BsAb-treated
patients.
incidence
was
stable
over
past
8
years,
accounting
for
1–2%
all
adverse
events,
case
fatality
rate
29.63%
cases.
Myeloid
leukemias
non-Hodgkin’s
lymphoma
were
more
frequent
in
blinatumomab
recipients,
while
solid
predominated
those
treated
teclistamab.
Time-to-onset
(TTO)
significantly
shorter
BsAb
recipients
compared
non-recipients,
weight
treatment
duration
influencing
TTO,
no
significant
differences
TTO
observed
across
different
products,
ages,
genders.
Our
findings
highlight
first
year
as
critical
window
early
detection
intervention.
Although
overall
lower
than
CAR-T,
outcomes
comparable
both
groups.
patterns
statistically
similar
two
Conclusion
study
provides
detailed
characterization
post-BsAb,
underscoring
need
continued
pharmacovigilance
individualized
management
mitigate
risks
patients
undergoing
therapy.
International Journal of Molecular Sciences,
Год журнала:
2021,
Номер
23(1), С. 449 - 449
Опубликована: Дек. 31, 2021
is
one
of
the
most
common
pathogens
responsible
for
infections,
including
pneumonia,
urinary
tract
and
bacteremias.
The
increasing
prevalence
multidrug-resistant
Recent
data
from
the
European
Antimicrobial
Resistance
Surveillance
Network
(EARS-Net)
show
a
large
increase
of
+57%
in
Acinetobacter
species
bloodstream
infections
Union
and
Economic
Area
first
years
COVID-19
pandemic
(2020-2021)
compared
with
2018-2019.
Most
were
resistant
to
carbapenems,
intensive
care
units,
countries
≥
50%
carbapenem
resistance
spp.
This
highlights
requirement
for
reinforced
preparedness
infection
prevention
control
Europe.
Antibiotics,
Год журнала:
2022,
Номер
11(6), С. 826 - 826
Опубликована: Июнь 20, 2022
The
coronavirus
disease
2019
(COVID-19)-pandemic-related
overload
of
health
systems
has
compromised
the
application
antimicrobial
stewardship
(AS)
models
and
infection
prevention
control
(IPC)
programs.
We
aimed
to
evaluate
impact
COVID-19
on
consumption
(AC)
resistance
(AMR)
in
University
Hospital
Modena.
A
time
series
analysis
with
an
autoregressive
integrated
moving
average
model
was
conducted
from
January
2015
October
2021
AC
whole
hospital
intensive
care
unit
(ICU),
incidence
density
(ID)
bloodstream
infections
(BSIs)
due
main
multidrug-resistant
organisms,
C.
difficile
(CDIs).
After
initial
peak
during
period,
a
decrease
trend
observed,
both
at
(CT:
−1.104,
p
=
0.025)
ICU
levels
−4.47,
0.047),
no
significant
difference
single
classes.
Among
Gram-negative
isolates,
we
observed
increase
only
level
BSIs
carbapenem-susceptible
Pseudomonas
aeruginosa
(CL:
1.477,
95%
CI
0.130
2.824,
0.032).
Considering
Gram-positive
bacteria,
methicillin-resistant
Staphylococcus
aureus
CDIs
were
though
they
did
not
reach
statistical
significance
0.72,
−0.039
1.48,
0.062;
CT:
1.43,
−0.002
2.863,
0.051;
respectively).
Our
findings
demonstrated
that
increases
AMR
appeared
first
wave
may
be
later
controlled
by
restoring
IPC
AS
programs
pre-epidemic
levels.
coordinated
healthcare
effort
is
necessary
address
longer-term
avoid
irreversible
consequences
AMR.
Antibiotics,
Год журнала:
2023,
Номер
12(6), С. 974 - 974
Опубликована: Май 28, 2023
This
study
aimed
to
evaluate
the
frequency
of
isolation
Staphylococcus
aureus
from
different
pathological
samples
processed
in
Microbiology
Laboratory
National
Institute
Infectious
Diseases
"Prof.
Dr.
Matei
Balș",
Romania,
between
1
January
2017
and
31
December
2022,
aiming
establish
ratio
methicillin-resistant
methicillin-susceptible
strains
antibiotic
resistance
pattern
isolated
microorganisms.
The
data
isolates
originating
routine
diagnostic
tasks
were
analyzed
retrospectively
using
laboratory
microbiology
department.
Up
39.11%
resistant
oxacillin
(MRSA),
with
49.97%
erythromycin
36.06%
inducible
clindamycin.
Resistance
rates
ciprofloxacin,
rifampicin,
gentamicin,
trimethoprim-sulfamethoxazole
9.98%,
5.38%,
5.95%,
0.96%,
respectively.
There
was
no
vancomycin.
Between
percentage
MRSA
decreased
41.71%
33.63%,
sharply
increasing
42.42%
2021
(the
year
COVID-19
pandemic,
when
lower
respiratory
tract
infections
higher
than
that
wounds
or
blood,
as
previous
years).
showed
a
high
(39.11%
overall)
proportion
these
blood
(42.49%)
compared
other
clinical
specimens.