Impact of COVID-19 on Antimicrobial Consumption and Spread of Multidrug-Resistance in Bacterial Infections

Antibiotics, Год журнала: 2022, Номер 11(4), С. 535 - 535

Опубликована: Апрель 18, 2022

The spread of COVID-19 pandemic may have affected antibiotic consumption patterns and the prevalence colonized or infected by multidrug-resistant (MDR) bacteria. We investigated differences in antibiotics easily prone to resistance MDR bacteria during (March 2020 September 2021) compared pre-pandemic period 2018 2019). Data on usage infections caused methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE), carbapenem-resistant Enterobacteriaceae (CRE), Acinetobacter baumannii (CRAB), Pseudomonas aeruginosa (CRPA) were obtained from hospitalized patients four university hospitals. penicillin with β-lactamase inhibitors (3.4% ward, 5.8% intensive care unit (ICU)), carbapenems (25.9% 12.1% ICU) increased period. MRSA (4.7%), VRE (49.0%), CRE (22.4%), CRPA (20.1%) isolated clinical samples ward (26.7%) (36.4%) ICU significantly increased, respectively. Meanwhile, only (38.7%) surveillance increased. is associated has influenced isolates.

Язык: Английский

---

Increased Detection of Carbapenemase-Producing Enterobacterales Bacteria in Latin America and the Caribbean during the COVID-19 Pandemic

Emerging infectious diseases, Год журнала: 2022, Номер 28(11), С. 1 - 8

Опубликована: Окт. 26, 2022

During 2020-2021, countries in Latin America and the Caribbean reported clinical emergence of carbapenemase-producing Enterobacterales that had not been previously characterized locally, increased prevalence carbapenemases detected, co-production multiple some isolates. These increases were likely fueled by changes related to COVID-19 pandemic, including empirical antibiotic use for potential COVID-19-related bacterial infections healthcare limitations resulting from rapid rise cases. Strengthening antimicrobial resistance surveillance, epidemiologic research, infection prevention control programs stewardship settings can help prevent transmission Enterobacterales.

Язык: Английский

---

Different epidemiology of bloodstream infections in COVID-19 compared to non-COVID-19 critically ill patients: a descriptive analysis of the Eurobact II study

Critical Care, Год журнала: 2022, Номер 26(1)

Опубликована: Окт. 18, 2022

Abstract Background The study aimed to describe the epidemiology and outcomes of hospital-acquired bloodstream infections (HABSIs) between COVID-19 non-COVID-19 critically ill patients. Methods We used data from Eurobact II study, a prospective observational multicontinental cohort on HABSI treated in ICU. For current analysis, we selected centers that included both performed descriptive statistics terms patients’ characteristics, source infection microorganism distribution. studied association status mortality using multivariable fragility Cox models. Results A total 53 19 countries over 5 continents were eligible. Overall, 829 patients (median age 65 years [IQR 55; 74]; male, n = 538 [64.9%]) for HABSI. Included comprised 252 (30.4%) 577 (69.6%) time interval hospital admission was similar groups. Respiratory sources (40.1 vs. 26.0%, p < 0.0001) primary (25.4% 17.2%, 0.006) more frequent had often enterococcal (20.5% 9%) Acinetobacter spp. (18.8% 13.6%) HABSIs. Bacteremic an increased hazard ratio (HR) versus (HR 1.91, 95% CI 1.49–2.45). Conclusions showed differed Enterococcal predominated with elevated risk mortality. Trial registration ClinicalTrials.org number NCT03937245 . Registered 3 May 2019.

Язык: Английский

---

ESKAPE and Beyond: The Burden of Coinfections in the COVID-19 Pandemic

Pathogens, Год журнала: 2023, Номер 12(5), С. 743 - 743

Опубликована: Май 22, 2023

The ESKAPE group constitute a threat to public health, since these microorganisms are associated with severe infections in hospitals and have direct relationship high mortality rates. presence of bacteria had impact on the incidence healthcare-associated coinfections SARS-CoV-2 pandemic. In recent years, pathogens shown resistance multiple antibiotic families. high-risk clones within this contributes spread mechanisms worldwide. pandemic, were implicated severely ill COVID-19 patients. aim review is describe main involved patients, addressing mainly antimicrobial mechanisms, epidemiology, clones.

Язык: Английский

---

Characteristics of second primary malignancies following bispecific antibodies therapy

Journal for ImmunoTherapy of Cancer, Год журнала: 2025, Номер 13(4), С. e011200 - e011200

Опубликована: Апрель 1, 2025

Background The risk of secondary primary malignancies (SPMs) associated with bispecific antibody (BsAb)—a promising alternative to chimeric antigen receptor (CAR)-T therapy—remains insufficiently explored. Methods Using large-scale, real-world data from the US Food and Drug Administration’s Adverse Event Reporting System, we identified relative frequency characteristics SPMs following BsAbs therapy conducted a comprehensive comparison treatment-related SPM profiles between CAR-T therapies. Results We 108 cases among 10,280 BsAb-treated patients. incidence was stable over past 8 years, accounting for 1–2% all adverse events, case fatality rate 29.63% cases. Myeloid leukemias non-Hodgkin’s lymphoma were more frequent in blinatumomab recipients, while solid predominated those treated teclistamab. Time-to-onset (TTO) significantly shorter BsAb recipients compared non-recipients, weight treatment duration influencing TTO, no significant differences TTO observed across different products, ages, genders. Our findings highlight first year as critical window early detection intervention. Although overall lower than CAR-T, outcomes comparable both groups. patterns statistically similar two Conclusion study provides detailed characterization post-BsAb, underscoring need continued pharmacovigilance individualized management mitigate risks patients undergoing therapy.

Язык: Английский

---

Antibiotic Heteroresistance in Klebsiella pneumoniae

International Journal of Molecular Sciences, Год журнала: 2021, Номер 23(1), С. 449 - 449

Опубликована: Дек. 31, 2021

is one of the most common pathogens responsible for infections, including pneumonia, urinary tract and bacteremias. The increasing prevalence multidrug-resistant

Язык: Английский

---

Large increase in bloodstream infections with carbapenem-resistant Acinetobacter species during the first 2 years of the COVID-19 pandemic, EU/EEA, 2020 and 2021

Eurosurveillance, Год журнала: 2022, Номер 27(46)

Опубликована: Ноя. 17, 2022

Recent data from the European Antimicrobial Resistance Surveillance Network (EARS-Net) show a large increase of +57% in Acinetobacter species bloodstream infections Union and Economic Area first years COVID-19 pandemic (2020-2021) compared with 2018-2019. Most were resistant to carbapenems, intensive care units, countries ≥ 50% carbapenem resistance spp. This highlights requirement for reinforced preparedness infection prevention control Europe.

Язык: Английский

---

Long-Term Impact of the COVID-19 Pandemic on In-Hospital Antibiotic Consumption and Antibiotic Resistance: A Time Series Analysis (2015–2021)

Antibiotics, Год журнала: 2022, Номер 11(6), С. 826 - 826

Опубликована: Июнь 20, 2022

The coronavirus disease 2019 (COVID-19)-pandemic-related overload of health systems has compromised the application antimicrobial stewardship (AS) models and infection prevention control (IPC) programs. We aimed to evaluate impact COVID-19 on consumption (AC) resistance (AMR) in University Hospital Modena. A time series analysis with an autoregressive integrated moving average model was conducted from January 2015 October 2021 AC whole hospital intensive care unit (ICU), incidence density (ID) bloodstream infections (BSIs) due main multidrug-resistant organisms, C. difficile (CDIs). After initial peak during period, a decrease trend observed, both at (CT: −1.104, p = 0.025) ICU levels −4.47, 0.047), no significant difference single classes. Among Gram-negative isolates, we observed increase only level BSIs carbapenem-susceptible Pseudomonas aeruginosa (CL: 1.477, 95% CI 0.130 2.824, 0.032). Considering Gram-positive bacteria, methicillin-resistant Staphylococcus aureus CDIs were though they did not reach statistical significance 0.72, −0.039 1.48, 0.062; CT: 1.43, −0.002 2.863, 0.051; respectively). Our findings demonstrated that increases AMR appeared first wave may be later controlled by restoring IPC AS programs pre-epidemic levels. coordinated healthcare effort is necessary address longer-term avoid irreversible consequences AMR.

Язык: Английский

---

Antimicrobial Resistance of Staphylococcus aureus Isolated between 2017 and 2022 from Infections at a Tertiary Care Hospital in Romania

Antibiotics, Год журнала: 2023, Номер 12(6), С. 974 - 974

Опубликована: Май 28, 2023

This study aimed to evaluate the frequency of isolation Staphylococcus aureus from different pathological samples processed in Microbiology Laboratory National Institute Infectious Diseases "Prof. Dr. Matei Balș", Romania, between 1 January 2017 and 31 December 2022, aiming establish ratio methicillin-resistant methicillin-susceptible strains antibiotic resistance pattern isolated microorganisms. The data isolates originating routine diagnostic tasks were analyzed retrospectively using laboratory microbiology department. Up 39.11% resistant oxacillin (MRSA), with 49.97% erythromycin 36.06% inducible clindamycin. Resistance rates ciprofloxacin, rifampicin, gentamicin, trimethoprim-sulfamethoxazole 9.98%, 5.38%, 5.95%, 0.96%, respectively. There was no vancomycin. Between percentage MRSA decreased 41.71% 33.63%, sharply increasing 42.42% 2021 (the year COVID-19 pandemic, when lower respiratory tract infections higher than that wounds or blood, as previous years). showed a high (39.11% overall) proportion these blood (42.49%) compared other clinical specimens.

Язык: Английский

---

Emerging Antimicrobial Resistance

Modern Pathology, Год журнала: 2023, Номер 36(9), С. 100249 - 100249

Опубликована: Июнь 21, 2023

Язык: Английский

---