Multidrug-resistant
bacteria
are
among
the
most
challenges
in
healthcare
systems.
According
to
World
Health
Organization,
these
that
belong
critical
and
high-priority
groups
resistant
carbapenem
or
multiple
antibiotics,
respectively.
They
commonly
associated
with
bone,
skin,
soft
tissue
infections,
current
treatment
strategies
involve
use
of
oral
intravenous
antibiotics.
Consequently,
infected
injured
sites
benefit
from
combined
antimicrobial
regenerative
action
during
tissues'
repair.
The
high
demand
for
effective
solutions
led
development
biocompatible
antibacterial
polymeric
membranes
local
therapy.
These
highly
porous
composed
by
nanofibers'
network
providing
a
matrix
cellular
proliferation
release
agents.
Nowadays,
there
several
techniques
produce
nanofibers
like
template
synthesis,
self-assembly,
freeze-drying,
melt-blowing,
electrospinning,
others.
Electrospinning
emerges
production
intrinsic
characteristics.
surface
area-to-volume
ratio
nanometric
diameters
allow
mimicking
innate
tissues
increasing
biomedical
fields'
attention.
Therefore,
electrospun
become
favoured
as
drug
delivery
systems,
improving
drugs'
dissolution
rates
while
maximizing
their
action.
Additionally,
they
permits
loading
drugs
higher
concentrations
control
rate
without
toxicity.
Hence,
antibiotics
have
been
common
encapsulated
medicinal
compounds
using
numerous
polymers
combinations
carriers.
versatility
electrospinning
advanced
approaches
which
combine
complex
locally
provide
agents
through
same
platform
consider
different
profiles.
Overall,
further
developments
should
continue
systems
meet
clinical
requirements.
Molecules,
Год журнала:
2023,
Номер
28(24), С. 8038 - 8038
Опубликована: Дек. 11, 2023
Drug
bioavailability
is
a
crucial
aspect
of
pharmacology,
affecting
the
effectiveness
drug
therapy.
Understanding
how
drugs
are
absorbed,
distributed,
metabolized,
and
eliminated
in
patients'
bodies
essential
to
ensure
proper
safe
treatment.
This
publication
aims
highlight
relevance
research
its
importance
In
addition
biochemical
activity,
also
plays
critical
role
achieving
desired
therapeutic
effects.
may
seem
obvious,
but
it
worth
noting
that
can
only
produce
expected
effect
if
level
concentration
be
achieved
at
point
patient's
body.
Given
differences
between
patients,
dosages,
administration
forms,
understanding
controlling
has
become
priority
pharmacology.
discusses
basic
concepts
factors
it.
We
looked
various
methods
assessing
bioavailability,
both
laboratory
clinic.
Notably,
introduction
new
technologies
tools
this
field
vital
achieve
advances
research.
cases
with
poorly
described
providing
deeper
complex
challenges
they
pose
medical
researchers
practitioners.
Simultaneously,
article
focuses
on
perspectives
trends
shape
future
regarding
which
development
modern
pharmacology
context,
offers
an
essential,
meaningful
contribution
toward
highlighting
bioavailability's
reliable
patient
The
text
identifies
areas
require
further
exploration.
World Journal of Emergency Surgery,
Год журнала:
2023,
Номер
18(1)
Опубликована: Окт. 16, 2023
Abstract
Antibiotics
are
recognized
widely
for
their
benefits
when
used
appropriately.
However,
they
often
inappropriately
despite
the
importance
of
responsible
use
within
good
clinical
practice.
Effective
antibiotic
treatment
is
an
essential
component
universal
healthcare,
and
it
a
global
responsibility
to
ensure
appropriate
use.
Currently,
pharmaceutical
companies
have
little
incentive
develop
new
antibiotics
due
scientific,
regulatory,
financial
barriers,
further
emphasizing
To
address
this
issue,
Global
Alliance
Infections
in
Surgery
established
international
multidisciplinary
task
force
295
experts
from
115
countries
with
different
backgrounds.
The
developed
position
statement
called
WARNING
(Worldwide
Antimicrobial
Resistance
National/International
Network
Group)
aimed
at
raising
awareness
antimicrobial
resistance
improving
prescribing
practices
worldwide.
outlined
10
axioms,
or
“golden
rules,”
that
all
healthcare
workers
should
consistently
adhere
Clinical Microbiology and Infection,
Год журнала:
2023,
Номер
30(4), С. 492 - 498
Опубликована: Окт. 18, 2023
To
evaluate
the
safety
and
efficacy
of
switching
from
intravenous
(IV)
to
oral
antimicrobial
therapy
in
patients
with
Enterobacterales
bacteraemia,
after
completion
3-5
days
microbiologically
active
IV
therapy.
Antimicrobial Stewardship & Healthcare Epidemiology,
Год журнала:
2024,
Номер
4(1)
Опубликована: Янв. 1, 2024
To
compare
outcomes
between
patients
discharged
on
intravenous
(IV)
versus
oral
(PO)
antibiotics
for
the
treatment
of
orthopedic
infections,
after
creation
an
IV-to-PO
guideline,
at
a
single
academic
medical
center
in
United
States.
Antibiotics,
Год журнала:
2023,
Номер
12(12), С. 1680 - 1680
Опубликована: Ноя. 29, 2023
Denmark
has
a
low
level
of
antimicrobial
resistance
(AMR).
Patients
hospitalized
with
suspected
infection
often
present
unspecific
symptoms.
This
challenges
the
physician
between
using
narrow-spectrum
antibiotics
in
accordance
guidelines
or
broad-spectrum
to
compensate
for
diagnostic
uncertainty.
The
aim
this
study
was
investigate
adherence
restrictive
antibiotic
guideline
most
common
emergency
departments
(EDs),
namely
community-acquired
pneumonia
(CAP).This
multicenter
descriptive
cross-sectional
included
adults
admitted
Danish
EDs
infection.
Data
were
collected
prospectively
from
medical
records.We
954
patients
analysis.
prescribed
penicillin
beta-lactamase
inhibitor
at
4
h
(307
(32.2%)),
48
(289
(30.3%)),
and
day
5
after
admission
(218
(22.9%)).
empirical
treatment
CAP
followed
126
(31.3%)
patients.
At
h,
administered
intravenously
244
(60.7%)
5,
218
(54.4%)
received
oral
antibiotics.Adherence
poor.
In
country
policy,
infections
are
commonly
treated
against
recommendations.
