Whereas
there
is
an
increasing
number
of
scientific
publications
investigating
the
optimal
anti-biotic
treatment
for
diabetic
foot
infections,
we
are
lacking
corresponding
data
in
adult
non-diabetic
(postsurgical)
infection
population.
We
therefore
established
one
largest
single-center
databases
on
this
topic
and
retrospectively
investigate
failures
a
combined
sur-gical
antibiotic
therapy
surgical
site
infections.
Overall,
17.4%
episodes
expe-rienced
any
therapeutic
failures;
especially
among
infected
ankle
prostheses.
In
contrast,
neither
age,
biological
sex,
pathogens,
duration
post-debridement
treatment,
debridement,
or
use
negative-pressure
wound
care
could
alter
failure
risk.
multivariate
logistic
regression
analyses,
postsur-gical
was
completely
indifferent
(as
continuous
variable
with
odds
ratio
1.0,
95%
confidence
interval
0.96-1.03),
when
stratified
into
inter-tertiary
groups.
Our
results
poten-tially
enable
shorter
applications
systemic
antibiotics
favor
better
stewardship
Consecutive
prospective-randomized
trials
under
way
to
identify
eligible
patient
populations
potentially
durations
infections
after
elective
surgery.
Journal of Clinical Medicine,
Год журнала:
2023,
Номер
12(21), С. 6808 - 6808
Опубликована: Окт. 27, 2023
(1)
Objectives:
This
study
investigated
the
optimal
duration
of
antibiotic
therapy
and
determined
risk
factors
associated
with
relapse
in
patients
culture-proven
septic
arthritis
native
joints.
(2)
Methods:
A
retrospective
review
was
conducted
on
aged
≥18
years
diagnosed
joint
arthritis,
bacteria
isolated
from
joints
and/or
blood.
The
exclusion
criteria
were
prosthetic
infections
cases
no
identified
microorganisms.
outcomes
assessed
remission
groups.
(3)
Results:
Among
479
137
met
inclusion
criteria,
a
median
follow-up
2.7
years.
rate
9.5%,
which
mainly
occurred
within
30
days
after
treatment
completion.
Compared
group,
group
showed
significantly
higher
proportion
that
received
for
≤
4
weeks
(4.8%
vs.
46.2%,
p
<
0.001),
synovial
fluid
white
blood
cell
(WBC)
counts
≥150
×
103/mm3
(25.3%
60.0%,
=
0.030),
acute
kidney
injury
(19.2%
50%,
0.024),
extended-spectrum
beta-lactamases-producing
Enterobacteriaceae
(0.8
15.4%,
0.024).
Independent
as
(odds
ratio
(OR),
25.47;
95%
confidence
interval
(CI),
1.57-412.33;
0.023)
WBC
(OR,
17.46;
CI,
1.74-175.62;
0.015).
(4)
Conclusions:
Patients
require
vigilant
monitoring
relapse,
particularly
when
treated
regimens
administered
less
than
four
or
aspirates
exhibit
elevated
at
diagnosis.
Current Opinion in Infectious Diseases,
Год журнала:
2023,
Номер
36(6), С. 462 - 472
Опубликована: Сен. 21, 2023
Purpose
of
review
This
will
describe
role
shorter
antibiotic
therapies,
early
switch
from
intravenous
to
oral
therapy,
and
artificial
intelligence
in
infectious
diseases.
Recent
findings
There
is
evidence
that
courses
antibiotics
are
noninferior
standard
durations
therapy.
has
been
demonstrated
with
Enterobacterales
bacteremia
can
be
treated
7
days
community
acquired
pneumonia
3
ventilator
associated
just
The
conversion
therapy
treating
bacteremia,
endocarditis
bone
joint
infections
safe
effective
reduces
line
complications
costs.
Also,
for
clean
surgical
procedures
only
one
dose
needed,
but
it
should
the
most
which
cefazolin.
means
avoiding
clindamycin,
removing
penicillin
allergies
where
possible
improved
outcomes.
Finally,
incorporate
into
using
wisely
rapidly
emerging
still
stages.
Summary
In
wisely,
targeting
such
as
low
hanging
fruit.
future
could
automate
a
lot
this
work
exciting
needs
proven.
Video
abstract
http://links.lww.com/COID/A50
Antibiotics
have
played
a
pivotal
role
in
modern
medicine,
drastically
reducing
mortality
rates
associated
with
bacterial
infections.
Despite
their
significant
contributions,
the
emergence
of
antibiotic
resistance
has
become
formidable
challenge,
necessitating
re-evaluation
use
practices.
The
widespread
belief
clinical
practice
that
bactericidal
antibiotics
are
inherently
superior
to
bacteriostatic
ones
lacks
consistent
support
from
evidence
randomized
controlled
trials
(RCTs).
With
latest
evidence,
certain
infections
demonstrated
equal
or
even
efficacy
agents.
Furthermore,
within
practice,
there
is
tendency
indiscriminately
order
urine
cultures
for
febrile
patients,
cases
where
alternative
etiologies
might
be
present.
Consequently,
upon
obtaining
positive
culture
result,
patients
often
receive
antimicrobial
prescriptions
despite
absence
indications
warranting
such
treatment.
it
prevailing
notion
among
physicians
extended
durations
therapy
confer
potential
benefits
and
mitigate
resistance.
Contrary
this
belief,
empirical
refutes
assertions.
This
article
aims
address
common
myths
misconceptions
field
infectious
diseases.
