Neuromodulation with Ultrasound: Hypotheses on the Directionality of Effects and a Community Resource DOI Open Access

Hugo Caffaratti,

Ben Slater, Nour Shaheen

и другие.

Опубликована: Дек. 6, 2024

Low-intensity Transcranial Ultrasound Stimulation (TUS) is a promising non-invasive technique for deep-brain stimulation and focal neuromodulation. Research with animal models computational modelling has raised the possibility that TUS can be biased towards enhancing or suppressing neural function. Here, we first conduct systematic review of human studies perturbing function alleviating brain disorders. We then collate set hypotheses on directionality effects an initial meta-analysis study reported outcomes to date ( n = 32 studies, 37 experiments). find parameters such as duty cycle show some predictability regarding whether targeted area’s likely enhanced suppressed. Given sample sizes are exponentially increasing, recognize results stabilize change further reported. Therefore, conclude by establishing Iowa-Newcastle (inTUS) resource reporting support hypothesis testing greater precision in neuromodulation TUS.

Язык: Английский

The future of transcranial ultrasound as a precision brain interface DOI Creative Commons

Keith E. Murphy,

Elsa Fouragnan

PLoS Biology, Год журнала: 2024, Номер 22(10), С. e3002884 - e3002884

Опубликована: Окт. 29, 2024

Our understanding of brain circuit operations and disorders has rapidly outpaced our ability to intervene restore them. Developing technologies that can precisely interface with any region may combine diagnostics therapeutic intervention, expediting personalised medicine. Transcranial ultrasound stimulation (TUS) is a promising noninvasive solution this challenge, offering focal precision scalability. By exploiting the biomechanics pressure waves on tissue, TUS enables multi-site targeted neuromodulation across distributed circuits in cortex deeper areas alike. In Essay, we explore emergent evidence functionally test modify dysfunctional regions, effectively serving as search rescue tool for brain. We define challenges opportunities faced by it moves towards greater target integration advanced monitoring interventional technology. Finally, propose roadmap evolution progresses from research clinically validated disorders.

Язык: Английский

Процитировано

5
Delay- and Pressure-Dependent Neuromodulatory Effects of Transcranial Ultrasound Stimulation DOI Creative Commons
Cyril Atkinson-Clément,

Mohammad Alkhawashki,

Marilyn Gatica

и другие.

Neuromodulation Technology at the Neural Interface, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Despite the growing interest in transcranial focused ultrasound stimulation (TUS), our understanding of its underlying mechanisms remains limited. In this study, we aimed to investigate effects TUS on several functional magnetic resonance imaging metrics by considering their latency, duration, and relationship with applied acoustic pressure. We recruited 22 healthy volunteers used a pre- vs post-TUS protocol. Half were stimulated right inferior frontal cortex other half thalamus. The fractional amplitudes low-frequency fluctuations, regional homogeneity, degree centrality, local connectivity density, eigenvector centrality considered. These compared before at three different time points first hour after TUS. Our results showed that 1) primarily alters both global levels; 2) stronger alterations are observed when delay increases 3) pressure is close maximum. suggest some consequences might not be immediate, inviting us revise premise immediate will progressively disappear.

Язык: Английский

Процитировано

0
Temporal Dynamics of Offline Transcranial Ultrasound Stimulation DOI Creative Commons
Cyril Atkinson-Clément, David Howett,

Mohammad Alkhawashki

и другие.

Current Research in Neurobiology, Год журнала: 2025, Номер 8, С. 100148 - 100148

Опубликована: Март 6, 2025

Transcranial ultrasound stimulation (TUS) is a promising non-invasive neuromodulation modality, characterized by deep-brain accuracy and the capability to induce longer-lasting effects. However, most TUS datasets are underpowered, hampering efforts identify longevity temporal dynamics. This primate case was studied awake with over 50 fMRI datasets, without left anterior hippocampus TUS. We therefore amassed highest-powered dataset date required reveal Most of effects were found in region itself alongside default mode sensorimotor networks. Seed-based functional connectivity exhibited time-constrained alteration which dissipated ∼60 min post-TUS. Intrinsic activity measure regional homogeneity displayed extended diffusivity longer durations. high-powered allowed predicting using pre-stimulation features that can now extend modeling individuals scanned less extensively. report reveals diversity dynamics help advance long-lasting human applications.

Язык: Английский

Процитировано

0
Novel NIBS in psychiatry: Unveiling TUS and TI for research and treatment DOI Creative Commons
F Sharif, Catherine J. Harmer, Miriam C. Klein-Flügge

и другие.

Brain and Neuroscience Advances, Год журнала: 2025, Номер 9

Опубликована: Март 1, 2025

Mental disorders pose a significant global burden and constitute major cause of disability worldwide. Despite strides in treatment, substantial number patients do not respond adequately, underscoring the urgency for innovative approaches. Traditional non-invasive brain stimulation techniques show promise, yet grapple with challenges regarding efficacy specificity. Variations mechanistic understanding reliability among methods are common, limited spatial precision physical constraints hindering ability to target subcortical areas often implicated disease aetiology. Novel such as transcranial ultrasonic temporal interference have gained notable momentum recent years, possibly addressing these shortcomings. Transcranial (TUS) offers exceptional deeper penetration compared conventional electrical magnetic techniques. Studies targeting diverse array regions shown its potential affect neuronal excitability, functional connectivity symptoms psychiatric depressive disorder. Nevertheless, planning acoustic interactions skull must be tackled widespread adoption research potentially clinical settings. Similar stimulation, (TI) traditional albeit requiring comparatively higher current equivalent neural effects. Promising still sparse highlights TI’s selectively modulate activity, showing utility psychiatry. Overall, like only open new avenues but also hold effective treatments However, realising their full necessitates practical optimising application effectively.

Язык: Английский

Процитировано

0
Non-invasive Ultrasound Deep Neuromodulation of the Human Nucleus Accumbens Increases Win-Stay Behaviour DOI Creative Commons
Siti N. Yaakub, Nadège Bault,

Mathilde Lojkiewiez

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июль 25, 2024

Abstract Current methods for directly modulating activity in deep human brain structures are limited and invasive. Here, we demonstrate modulation of using non-invasive transcranial ultrasound stimulation (TUS) show it exerts selective effects on learning decision making. 26 healthy adults participated a within-subject repeated TUS– functional magnetic resonance imaging (fMRI) experiment with three sonication conditions. Participants performed probabilistic task while undergoing fMRI scanning after counterbalanced 80 s 5 Hz repetitive TUS the nucleus accumbens (NAcc), dorsal anterior cingulate cortex (dACC), or Sham. TUS-NAcc altered parametric BOLD response to reward expectation NAcc adjacent areas. Moreover, induced changes specific reward-related behaviours including use win–stay strategy, rate following rewards, curve choices rewarding option, repetition rewarded choices. The results TUS’s utility deep-brain neuromodulation causal role from positive outcomes. Summary Precisely neuromodulating regions humans could bring transformative advancements both cognitive neuroscience disorder treatment. In within subject experiment, twenty-six underwent series procedures, accumbens, cortex, no sonication. Results revealed that (NAcc) behaviours, tendency stick winning choices, specifically feedback, repeating Functional scans showed corresponding neural expectations targeted interconnected These findings as well feasibility modulate making research tool potential component future treatments disorders involving sensitivity.

Язык: Английский

Процитировано

2
Neuromodulation with Ultrasound: Hypotheses on the Directionality of Effects and a Community Resource DOI Open Access

Hugo Caffaratti,

Ben Slater, Nour Shaheen

и другие.

Опубликована: Дек. 6, 2024

Low-intensity Transcranial Ultrasound Stimulation (TUS) is a promising non-invasive technique for deep-brain stimulation and focal neuromodulation. Research with animal models computational modelling has raised the possibility that TUS can be biased towards enhancing or suppressing neural function. Here, we first conduct systematic review of human studies perturbing function alleviating brain disorders. We then collate set hypotheses on directionality effects an initial meta-analysis study reported outcomes to date ( n = 32 studies, 37 experiments). find parameters such as duty cycle show some predictability regarding whether targeted area’s likely enhanced suppressed. Given sample sizes are exponentially increasing, recognize results stabilize change further reported. Therefore, conclude by establishing Iowa-Newcastle (inTUS) resource reporting support hypothesis testing greater precision in neuromodulation TUS.

Язык: Английский

Процитировано

2
Neuromodulation with Ultrasound: Hypotheses on the Directionality of Effects and a Community Resource DOI Open Access

Hugo Caffaratti,

Ben Slater, Nour Shaheen

и другие.

Опубликована: Дек. 6, 2024

Low-intensity Transcranial Ultrasound Stimulation (TUS) is a promising non-invasive technique for deep-brain stimulation and focal neuromodulation. Research with animal models computational modelling has raised the possibility that TUS can be biased towards enhancing or suppressing neural function. Here, we first conduct systematic review of human studies perturbing function alleviating brain disorders. We then collate set hypotheses on directionality effects an initial meta-analysis study reported outcomes to date ( n = 32 studies, 37 experiments). find parameters such as duty cycle show some predictability regarding whether targeted area’s likely enhanced suppressed. Given sample sizes are exponentially increasing, recognize results stabilize change further reported. Therefore, conclude by establishing Iowa-Newcastle (inTUS) resource reporting support hypothesis testing greater precision in neuromodulation TUS.

Язык: Английский

Процитировано

0