The repair capacity spectrum of human skeletal muscle injury from sports to surgical trauma settings

The Journal of Physiology, Год журнала: 2025, Номер unknown

Опубликована: Май 5, 2025

Abstract Skeletal muscle injury and repair have been a major research focus for more than century. Muscle injuries are defined by their cause anatomical location lie on spectrum in terms of outcomes. From contraction‐induced necrosis, which initiates regenerative myogenesis complete restoration tissue architecture function to, at the other end spectrum, traumatic volumetric loss (VML), where substantial portions (or whole) lost, leaving patient with permanent physical disability. Strain found between these two extremes characterised healing scar formation high re‐rupture rate. Across types, discriminating feature successful outcome is preservation extracellular matrix (ECM) muscle‐tendon complex, particular myotendinous junction (MTJ). Numerous experimental models, imaging techniques molecular analyses led to thorough understanding how stem cells interact immune, vessel stroma‐associated during myogenesis. Paradoxically, treatment strain VML has not improved, engineering approaches remain distant hope. Important issues this field include matching level detail that exists animal regeneration human data identifying site disruption injury. We propose closer collaboration cell biologists, physiologists, sports medicine practitioners orthopaedic surgeons required improve outcomes, particularly VML. image

Язык: Английский

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The musculotendinous interface: insights into development, injury, and recovery for military medical applications

Frontiers in Physiology, Год журнала: 2025, Номер 16

Опубликована: Май 6, 2025

Musculoskeletal injuries (MSKIs) are a major cause of morbidity and lost duty time for military service members, impacting overall readiness, with overuse being particularly prevalent among them. Musculotendinous injuries, affecting the musculotendinous unit, especially problematic due to their long recovery times limited treatment options. To better understand these this review delves into developmental, homeostatic, structural biology units, focus on junction (MTJ). Additionally, it explores biomechanical model unit complexities endogenous repair processes muscle, tendon, MTJ injuries. Based insights, discusses promising therapeutic approaches treating such as anabolic agents, metabolic reprogramming, scaffold or cell-based therapies, physical therapy. These emerging therapies offer potential avenues accelerating healing, reducing time, improving long-term outcomes Ultimately, further research in area could significantly enhance readiness by mitigating impact MSKIs members.

Язык: Английский

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Interface tissues of the mesoderm: Periosteum, ligament, interosseous membrane, & myofascial tissues, an inspiration for next generation medical textiles

Current Opinion in Biomedical Engineering, Год журнала: 2024, Номер 31, С. 100543 - 100543

Опубликована: Май 20, 2024

Язык: Английский

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Regeneration of Interfaces Bridging Disparate Tissues and Systems of the Human Body

Current Opinion in Biomedical Engineering, Год журнала: 2024, Номер 32, С. 100552 - 100552

Опубликована: Июль 11, 2024

Язык: Английский

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