Current Opinion in Chemical Engineering, Год журнала: 2025, Номер 48, С. 101108 - 101108
Опубликована: Март 4, 2025
Язык: Английский
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Organic Process Research & Development, Год журнала: 2025, Номер 29(2), С. 545 - 554
Опубликована: Фев. 11, 2025
The robustness of the flash thermal racemization optically active 1-phenylethylamine over Pd/γ-Al2O3 was studied by applying split-plot design-of-experiments (DoE), where effects temperature, flow rate, and concentration (3-factors) on e.e. selectivity (2-responses) were examined quantified. same also interrogated using multivariate ramps in transient to produce response surfaces for reaction space. set optimal conditions process identified both approaches, relationships between variables observed: while extent (e.e.) can be directly correlated a more complex relationship temperature rate uncovered.
Язык: Английский
Процитировано
0
Drug Development and Industrial Pharmacy, Год журнала: 2025, Номер unknown, С. 1 - 28
Опубликована: Фев. 24, 2025
Introduction Optimization of pharmaceutical formulations requires advanced tools to ensure quality, safety, and efficacy. Quality-by-Design (QbD), introduced by the FDA, emphasizes understanding controlling processes early in development. Advanced optimization methods, such as desirability, have surpassed traditional single-objective techniques. Others Weighted Goal Programming (WGP) offers unique advantages integrating decision-maker preferences, enabling balanced solutions for complex drug delivery systems. This study applies WGP optimize timolol-loaded nanoliposomes aligning with QbD principles.
Язык: Английский
Процитировано
0
Current Opinion in Chemical Engineering, Год журнала: 2025, Номер 48, С. 101108 - 101108
Опубликована: Март 4, 2025
Язык: Английский
Процитировано
0