Design of Experiments (DoE) in Manufacturing Process Optimization

Published: Jan. 1, 2025

Language: Английский

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Flash Thermal Racemization of Chiral Amine in Continuous Flow: An Exploration of Reaction Space Using DoE and Multivariate Transient Flow

Organic Process Research & Development, Journal Year: 2025, Volume and Issue: 29(2), P. 545 - 554

Published: Feb. 11, 2025

The robustness of the flash thermal racemization optically active 1-phenylethylamine over Pd/γ-Al2O3 was studied by applying split-plot design-of-experiments (DoE), where effects temperature, flow rate, and concentration (3-factors) on e.e. selectivity (2-responses) were examined quantified. same also interrogated using multivariate ramps in transient to produce response surfaces for reaction space. set optimal conditions process identified both approaches, relationships between variables observed: while extent (e.e.) can be directly correlated a more complex relationship temperature rate uncovered.

Language: Английский

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ENHANCING QUALITY-BY-DESIGN THROUGH WEIGHTED GOAL PROGRAMMING: A CASE STUDY ON FORMULATION OF ULTRADEFORMABLE LIPOSOMES

Drug Development and Industrial Pharmacy, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 28

Published: Feb. 24, 2025

Introduction Optimization of pharmaceutical formulations requires advanced tools to ensure quality, safety, and efficacy. Quality-by-Design (QbD), introduced by the FDA, emphasizes understanding controlling processes early in development. Advanced optimization methods, such as desirability, have surpassed traditional single-objective techniques. Others Weighted Goal Programming (WGP) offers unique advantages integrating decision-maker preferences, enabling balanced solutions for complex drug delivery systems. This study applies WGP optimize timolol-loaded nanoliposomes aligning with QbD principles.

Language: Английский

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Editorial overview: Digital design of pharmaceutical manufacturing processes

Current Opinion in Chemical Engineering, Journal Year: 2025, Volume and Issue: 48, P. 101108 - 101108

Published: March 4, 2025

Language: Английский

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