DESIGN, DEVELOPMENT, AND VALIDATION OF A NANOBIOSENSOR TO DETECT CIRCULATING MICROBIOME FOR CARDIOVASCULAR DISEASE RISK ASSESSMENT DOI Open Access
Nazim Nazeer,

Rakhi Dewangan,

Kaniz Zaidi

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Авг. 8, 2023

Abstract Cardiovascular disease (CVD) is a serious worldwide health concern that necessitates the development of novel diagnostic techniques for early identification and personalized healthcare management. Even before insights provided by gut microbiota, current research has demonstrated importance circulating microbiome (CMB) in evolution cardiometabolic illness risk progression. We developed nanobiosensor uses specific labeled capture probes with perovskite quantum dots (PQDs) to detect targeted 16S rRNA sequences peripheral milieu. With ideal applicability, specificity, sensitivity, this sensor delivers unique into presence characterization microbiota signatures. Developing nanophotonic detection method body fluids may pave way creating distinctive tool CVD prediction population-based screening programs low middle-income countries.

Язык: Английский

Emerging Technologies and Advanced Biomarkers for Enhanced Toxicity Prediction and Safety Pharmacology DOI Open Access

Tamer A. Addissouky

Advances in Clinical Toxicology, Год журнала: 2024, Номер 9(1), С. 1 - 9

Опубликована: Янв. 1, 2024

Background: Biomarkers are important tools in toxicology that can improve risk assessment, early detection of organ injury, and monitoring pharmacological responses. However, rigorous validation is necessary to justify use for regulatory decisionmaking. Purpose: This article reviews the current landscape surrounding established emerging biomarkers toxicity across multiple techniques, with a focus on assessment merits, limitations, needs. Main Body: An overview common clinical chemistry used safety liver, kidney, heart, inflammation first provided, highlighting their biological relevance applications detecting dysfunction. Novel protein enhanced sensitivity injury then discussed, such as microRNAs liver clusterin kidney. Metabolomic biomarker approaches assess biofluids mitochondrial outlined, along toxicogenomic markers susceptibility like HLA alleles. Non-invasive imaging techniques including ultrasound, MRI, PET tracers function explored provide additional modalities measurement. Emerging microphysiological systems high-throughput omics discovery also described. Conclusion: While great progress has been made, translation qualification novel remains challenging. review synthesizes key developments categories, evaluates readiness use, outlines strategic considerations fit-for-purpose advance integration into drug development programs.

Язык: Английский

Процитировано

6
Nanophotonic waveguide-based sensing of circulating cell-free mitochondrial DNA: implications for personalized medicine DOI

Prasan Kaur,

Nazim Nazeer, Vikas Gurjar

и другие.

Drug Discovery Today, Год журнала: 2024, Номер 29(8), С. 104086 - 104086

Опубликована: Июль 2, 2024

Язык: Английский

Процитировано

2
The enigma of mitochondrial epigenetic alterations in air pollution-induced neurodegenerative diseases DOI

Sayanti Acharyya,

Sruthy Hari Kumar,

Apoorva Chouksey

и другие.

NeuroToxicology, Год журнала: 2024, Номер 105, С. 158 - 183

Опубликована: Окт. 5, 2024

Язык: Английский

Процитировано

2
Air Pollution-Linked Epigenetic Modifications in Placental DNA: Prognostic Potential for Identifying Future Foetal Anomalies DOI

Sruthy Hari Kumar,

Sayanti Acharyya,

Apoorva Chouksey

и другие.

Reproductive Toxicology, Год журнала: 2024, Номер 129, С. 108675 - 108675

Опубликована: Июль 27, 2024

Язык: Английский

Процитировано

1
A Single Organic Fluorescent Probe for the Discrimination of Dual Spontaneous ROS in Living Organisms: Theoretical Approach DOI Creative Commons

Liang Fu,

He Huang, Zhongfu Zuo

и другие.

Molecules, Год журнала: 2023, Номер 28(19), С. 6983 - 6983

Опубликована: Окт. 9, 2023

Single-organic-molecule fluorescent probes with double-lock or even multi-lock response modes have attracted the attention of a wide range researchers. The number corresponding reports has rapidly increased in recent years. effective application mode single-molecule probe improved comprehensive understanding related targets' functions influences pathologic processes. Building highly efficient functional would benefit diagnosis and treatment diseases. Here, we conducted theoretical analysis synthesizing sensing mechanism this kind probe, thereby guiding design building new probes. In work, discuss detail electronic structure, electron excitation, character recently developed which could achieve discrimination profiling spontaneous reactive oxygen species (ROS, •OH, HClO) simultaneously. results provide insights that will help develop tools for biological medical fields.

Язык: Английский

Процитировано

2
Molecular insights into mitoepigenetic stress response signaling in age-associated cardiovascular disease risk DOI Creative Commons
N. Soni,

Prasan Kaur,

Vikas Gurjar

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Март 15, 2024

Abstract Cardiovascular diseases (CVD) represent a major challenge for the elderly population and continue to be among leading causes of mortality worldwide. The integrity mitochondria in peripheral lymphocytes can indicate age-related degenerative disorders, revealing balance between bioenergetics, inflammation, senescence. present study aims investigate impact aging on mitochondrial-mediated epigenetic stress response mechanisms both young individuals. Mitochondrial oxidative DNA damage, repair response, copy number, methylation, fusion, fission genes, electron transport chain enzyme complex activities, pro-inflammatory cytokine levels, associated were studied. results demonstrate that group experienced more significant disruption expression mitochondrial impaired (mtDNA) intricately linked mitochondrial-nuclear crosstalk, increasing their susceptibility CVD. findings highlight mitochondria’s crucial role cellular dynamics, influencing responses through fusion cycles. Overall, these insights provide valuable information about molecular processes linking dysfunction cardiovascular risks, paving way further exploration potential interventions aging-related health outcomes. Graphical Figure showing underlying mitoepigenetic signaling pathways age-associated diseases.

Язык: Английский

Процитировано

0
Unravelling the molecular dimensions of atmospheric Micro(nano)Plastics: Exploring potential impacts on human health and strategies for detection DOI
Nazim Nazeer, Arpit Bhargava, Nikita Soni

и другие.

Physics and Chemistry of the Earth Parts A/B/C, Год журнала: 2024, Номер 135, С. 103604 - 103604

Опубликована: Апрель 18, 2024

Язык: Английский

Процитировано

0
DESIGN, DEVELOPMENT, AND VALIDATION OF A NANOBIOSENSOR TO DETECT CIRCULATING MICROBIOME FOR CARDIOVASCULAR DISEASE RISK ASSESSMENT DOI Open Access
Nazim Nazeer,

Rakhi Dewangan,

Kaniz Zaidi

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Авг. 8, 2023

Abstract Cardiovascular disease (CVD) is a serious worldwide health concern that necessitates the development of novel diagnostic techniques for early identification and personalized healthcare management. Even before insights provided by gut microbiota, current research has demonstrated importance circulating microbiome (CMB) in evolution cardiometabolic illness risk progression. We developed nanobiosensor uses specific labeled capture probes with perovskite quantum dots (PQDs) to detect targeted 16S rRNA sequences peripheral milieu. With ideal applicability, specificity, sensitivity, this sensor delivers unique into presence characterization microbiota signatures. Developing nanophotonic detection method body fluids may pave way creating distinctive tool CVD prediction population-based screening programs low middle-income countries.

Язык: Английский

Процитировано

1