Novel Strategies for Preventing Fungal Infections—Outline
Pathogens,
Год журнала:
2025,
Номер
14(2), С. 126 - 126
Опубликована: Фев. 1, 2025
Fungal
infections
are
a
significant
global
health
challenge,
causing
approximately
3.8
million
deaths
annually,
with
immunocompromised
populations
particularly
at
risk.
Traditional
antifungal
therapies,
including
azoles,
echinocandins,
and
polyenes,
face
limitations
due
to
rising
resistance,
toxicity,
inadequate
treatment
options.
This
review
explores
innovative
strategies
for
preventing
managing
fungal
infections,
such
as
vaccines,
peptides,
nanotechnology,
probiotics,
immunotherapy.
Vaccines
offer
promising
avenues
long-term
protection,
despite
difficulties
in
their
development
complexity
immune
evasion
mechanisms.
Antifungal
peptides
provide
novel
class
of
agents
broad-spectrum
activity
reduced
resistance
risk,
whilst
nanotechnology
enables
targeted,
effective
drug
delivery
systems.
Probiotics
show
potential
vulvovaginal
candidiasis,
by
maintaining
microbial
balance.
Immunotherapy
leverages
system
modulation
enhance
defenses,
omics
technologies
deliver
comprehensive
insights
into
biology,
paving
the
way
therapeutic
vaccine
targets.
While
these
approaches
hold
immense
promise,
challenges
cost,
accessibility,
translational
barriers
remain.
A
coordinated
effort
among
researchers,
clinicians,
policymakers
is
critical
advancing
addressing
burden
effectively.
Язык: Английский
Combination of Machine Learning and COSMO-RS Thermodynamic Model in Predicting Solubility Parameters of Coformers in Production of Cocrystals for Enhanced Drug Solubility
Chemometrics and Intelligent Laboratory Systems,
Год журнала:
2024,
Номер
253, С. 105219 - 105219
Опубликована: Авг. 23, 2024
Язык: Английский
An exploration of the ocular mysteries linking nanoparticles to the patho-therapeutic effects against keratitis
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Март 6, 2025
Microbial
keratitis,
a
sight-threatening
corneal
infection,
remains
significant
global
health
concern.
Conventional
therapies
using
antimicrobial
agents
often
suffers
from
limitations
such
as
poor
drug
penetration,
side
effects,
and
occurrence
of
resistance,
with
prognosis.
Novel
treatment
techniques,
their
unique
properties
targeted
delivery
capabilities,
offers
promising
solution
to
overcome
these
challenges.
This
review
delves
into
timely
update
the
state-of-the-art
advance
therapeutics
for
keratitis
treatment.
The
diverse
microbial
origins
including
viral,
bacterial,
fungal
infections,
exploring
complex
pathogenic
mechanisms,
followed
by
resistance
mechanisms
in
pathogens
are
reviewed
briefly.
Importantly,
emerging
therapeutic
techniques
piezodynamic
therapy,
photothermal
photodynamic
nanoenzyme
metal
ion
therapy
summarized
this
showcasing
potential
traditional
treatments.
challenges
future
directions
nanotechnology-based
approaches
discussed,
focusing
on
safety,
targeting
strategies,
combination
therapies.
aims
inspire
researchers
revolutionize
accelerate
development
functional
materials
different
Язык: Английский
Advances in Nanoparticles in Targeted Drug Delivery- A Review
Results in Surfaces and Interfaces,
Год журнала:
2025,
Номер
unknown, С. 100529 - 100529
Опубликована: Апрель 1, 2025
Язык: Английский
Anti-fungal peptides: an emerging category with enthralling therapeutic prospects in the treatment of candidiasis
Critical Reviews in Microbiology,
Год журнала:
2024,
Номер
unknown, С. 1 - 37
Опубликована: Окт. 23, 2024
infections,
particularly
invasive
candidiasis,
pose
a
serious
global
health
threat.
Язык: Английский
Layer-by-Layer Biopolymer-Coated Deformable Liposomes–In Situ Gel: A Hybrid Strategy for Enhanced Ocular Delivery of Itraconazole: In Vitro and In Vivo Appraisal
Gels,
Год журнала:
2024,
Номер
11(1), С. 19 - 19
Опубликована: Дек. 31, 2024
Itraconazole
(ITZ)
is
a
potent
antifungal
agent.
Its
oral
administration
associated
with
systemic
toxicity,
and
its
efficacy
in
ocular
formulations
limited.
This
study
aims
to
enhance
ITZ’s
permeation
by
loading
it
into
deformable
liposomes
(DLs)
based
on
Tween
80
(T)
or
Poloxamer
188
(P).
Moreover,
ITZ
was
loaded
biopolymer-coated
DLs
augment
availability.
ITZ-loaded
were
coated
hyaluronic
acid
(HA-DLs),
chitosan
(CS-DLs),
layer-by-layer
coating
(CS/HA-DLs).
These
further
laden
pH-sensitive
situ
gels
provide
hybrid
system
intensify
their
adhesion
properties.
The
prepared
successfully
vesicle
sizes
nonorange
(<200
nm).
zeta
potential
values
of
DLS
negative
before
shifted
high
negativity
HA
positivity
CS
CS/HA
bilayer
coating.
variations
indicate
successful
coatings.
optimized
A
EE%
achieved
DLs-T:
89%
(CS/HA-DLs-T),
86%
(CS-DLs-T),
85%
(HA-DLs-T),
79%
(HA-DLs-T).
Therefore,
DLs-T
incorporated
gels,
displaying
optimal
gelling
capacity
viscosity.
release
rate
from
the
DLs-laden
slower
than
that
observed
uncoated
DLs-gel.
CS/HA-DLs-T
laden-in
showed
highest
ex
vivo
transcorneal
permeability
efficacy.
data
suggest
layer-by-layer-CS/HA-DLs-T
presents
hopeful
strategy
for
delivery
ITZ,
offering
promising
approach
managing
fungal
infections.
Язык: Английский