Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 6, 2025
Abstract
Neurodegenerative
diseases,
particularly
Alzheimer's
disease
and
Parkinson's
disease,
present
formidable
challenges
in
modern
medicine
due
to
their
complex
pathologies
the
absence
of
curative
treatments.
Despite
advances
symptomatic
management,
early
diagnosis
remains
essential
for
mitigating
progression
improving
patient
outcomes.
Traditional
diagnostic
methods,
such
as
MRI,
PET,
cerebrospinal
fluid
biomarker
analysis,
are
often
inadequate
detection
these
diseases.
Emerging
porous
materials,
including
metal–organic
frameworks
(MOFs),
covalent–organic
(COFs),
MXene,
zeolites,
silicon,
offer
promising
new
approaches
neurodegenerative
These
characterized
by
highly
tunable
physicochemical
properties,
have
potential
capture
concentrate
disease‐specific
biomarkers
amyloid‐beta
(Aβ),
tau
protein,
alpha‐synuclein
(α‐Syn).
The
integration
materials
into
advanced
biosensors
real‐time
holds
promise
revolutionizing
neurodiagnostic,
enabling
non‐invasive,
sensitive,
specific
platforms.
Furthermore,
incorporation
artificial
intelligence
(AI)
machine
learning
(ML)
techniques
analysis
sensor
data
enhances
accuracy
allows
more
efficient
interpretation
profiles.
AI
ML
can
optimize
feature
selection,
improve
pattern
recognition,
facilitate
prediction
progression,
making
them
indispensable
tools
personalized
medicine.
This
review
explores
diagnostics,
emphasizing
design,
functionality,
synergistic
role
advancing
clinical
applications.
ACS Biomaterials Science & Engineering,
Год журнала:
2023,
Номер
9(10), С. 5599 - 5609
Опубликована: Сен. 1, 2023
An
electrochemical
sensor
applied
for
dopamine
(DA)
detection
was
constructed.
easy
static
way
used
to
synthesize
bimetallic
CoNi-MOF.
Next,
it
mixed
with
graphene
oxide
(GO)
under
ultrasound
get
a
uniform
suspension.
Subsequently,
the
solution
coated
on
glassy
carbon
electrode
(GCE)
form
CoNi-MOF@ERGO/GCE
by
reduction
method.
The
interaction
between
CoNi-MOF
and
electrochemically
reduced
(ERGO)
enhances
electrocatalytic
performance
DA
detection.
has
wider
linear
range
(0.1–400
μM)
lower
limit
(0.086
optimum
conditions.
Furthermore,
been
test
in
human
serum
samples.
results
reveal
that
shows
excellent
performance,
which
will
provide
novel
idea
more
sensitive
quicker
Catalysts,
Год журнала:
2024,
Номер
14(8), С. 478 - 478
Опубликована: Июль 27, 2024
Deposition
at
oblique
vapor
incidence
angles
can
lead
to
the
growth
of
thin
films
with
dramatically
changed
morphological
features.
Herein,
thin-film
titanium
nanocolumnar
arrays
were
grown
on
a
graphene
monolayer/copper
foil
substrate
(TiNCs/Gm-Cufoil)
by
applying
physical
deposition
method,
through
magnetron
sputtering
an
angle.
Ti-nanocolumnar
ca.
200
nm
length
developed
throughout
different
morphologies
depending
topography.
It
was
found
that
over
as-fabricated
electrocatalyst,
electrooxidation
reaction
dopamine
is
facilitated,
allowing
quasi-reversible
protonated
quinone.
Additionally,
contrary
works
appeared
in
literature,
TiNCs/Gm-Cufoil
also
promotes
further
oxidation
leucodopaminechrome
dopaminechrome.
The
electrode
exhibited
two
linear
ranges
detection
(10–90
μM
sensitivity
value
0.14
μAμM−1cm−2
and
100–400
0.095
μAμM−1cm−2),
good
stability
time
about
30
days,
selectivity
for
detection.
Materials,
Год журнала:
2025,
Номер
18(2), С. 425 - 425
Опубликована: Янв. 17, 2025
Deep
eutectic
solvents
(DES)
have
emerged
as
versatile,
sustainable
media
for
the
synthesis
of
nanomaterials
due
to
their
low
toxicity,
tunability,
and
biocompatibility.
This
study
develops
a
one-step
method
modify
commercially
available
screen-printed
electrodes
(SPE)
using
laser-induced
pyrolysis
DES,
consisting
choline
chloride
tartaric
acid
with
dissolved
nickel
acetate
dispersed
graphene.
The
were
patterned
532
nm
continuous-wave
laser
in
situ
formation
Ni
nanoparticles
decorated
on
graphene
sheets
directly
SPE
surface
(Ni-G/SPE).
parameters,
specifically
power
concentration,
optimized
Nelder-Mead
produce
modified
Ni-G/SPEs
maximized
electrochemical
response
dopamine.
Electrochemical
characterization
developed
sensor
by
differential
pulse
voltammetry
revealed
its
broad
linear
detection
range
from
0.25
100
μM
high
sensitivity
limit
0.095
μM.
These
results
highlight
potential
laser-assisted
DES
advance
sensing
technologies,
particularly
biogenic
amines.