Europium Metal–Organic Framework with a Tetraphenylethylene-Based Ligand: A Dual-Mechanism Quenching Immunosensor for Enhanced Electrochemiluminescence via the Coordination Trigger

Analytical Chemistry, Год журнала: 2024, Номер 96(9), С. 3898 - 3905

Опубликована: Фев. 22, 2024

The effective applications of electrochemiluminescence (ECL) across various fields necessitate ongoing research into novel luminophores and ECL strategies. In this study, self-luminous flower-like nanocomposites (Eu-tcbpe-MOF) were prepared by coordination self-assembly using the aggregation-induced emission material 1,1,2,2-tetrakis(4-carboxyphenyl)ethylene (H4TCBPE) Eu(III) ions as precursors. Compared with monomers aggregates H4TCBPE, Eu-tcbpe-MOF exhibits stronger emission. Such enhanced is due to coordination-triggered (CT-ECL) enhancement effect. a cubic-structured nanocomposite (Co9S8@Au@MoS2) was used an efficient quencher, more sensitive detection platform achieved two quenching mechanisms: resonance energy transfer competitive consumption coreactants. N,N-Diethylethanolamine (DBAE) coreactant, DBAE has faster electron rate supply efficiency than traditional anodoluminescent coreactant tripropylamine, which effectively improves signal intensity Eu-tcbpe-MOF. Hence, sandwich-type immunosensor employing dual-quenching mechanism, utilizing probe Co9S8@Au@MoS2 achieving precise carcinoembryonic antigen from 0.1 pg·mL–1 100 ng·mL–1 limit 35.1 fg·mL–1.

Язык: Английский

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A Co-Reactive Immunosensor Based on Ti₃C₂T_x MXene@TiO₂–MoS₂ Hybrids Promoting luminol@Au@Ni–Co NCs Electrochemiluminescence for CYFRA 21–1 Detection

ACS Sensors, Год журнала: 2024, Номер 9(4), С. 1992 - 1999

Опубликована: Март 27, 2024

The construction of assays is capable accurately detecting cytokeratin-19 (CYFRA 21–1), which critical for the rapid diagnosis nonsmall cell lung cancer. In this work, a novel electrochemiluminescence (ECL) immunosensor based on co-reaction promotion luminol@Au@Ni–Co nanocages (NCs) as ECL probe by Ti3C2Tx MXene@TiO2–MoS2 hybrids accelerator was proposed to detect CYFRA 21–1. Ni–Co NCs, derivative Prussian blue analogs, can be loaded with large quantities Au NPs, luminol, and 21–1 secondary antibodies due their high specific surface area. To further improve sensitivity developed immunosensor, were prepared in situ growth TiO2 nanosheets highly conductive MXene, MoS2 homogeneously grown MXene@TiO2 surfaces hydrothermal method. possess excellent catalytic performance electro-redox H2O2 generating more O2·– obtaining optimal intensity luminol/H2O2 system. Under appropriate experimental conditions, quantitative detection range from 0.1 pg mL–1 100 ng mL–1, limit (LOD) 0.046 mL–1. present sensor has lower LOD wider linear range, provides new analytical assay early small-cell-type cancer labels.

Язык: Английский

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MXenes for Wearable Physical Sensors toward Smart Healthcare

ACS Nano, Год журнала: 2024, Номер 18(36), С. 24705 - 24740

Опубликована: Авг. 26, 2024

The gradual rise of personal healthcare awareness is accelerating the deployment wearable sensors, whose ability acquiring physiological vital signs depends on sensing materials. MXenes have distinct chemical and physical superiorities over other 2D nanomaterials for sensors. This review presents a comprehensive summary latest advancements in MXenes-based materials It begins with an introduction to special structural features performance, followed by in-depth exploration versatile functionalities. A detailed description different mechanisms also included illustrate contribution performance its improvement. In addition, real-world applications sensors monitoring are as well. remaining challenges their promising opportunities finally narrated, conjunction prospective future development.

Язык: Английский

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An electrochemical dopamine sensor based on CoMn2O4/CQDs nanocomposite modified carbon paste electrode

Microchemical Journal, Год журнала: 2025, Номер unknown, С. 112889 - 112889

Опубликована: Янв. 1, 2025

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Recent Advances in Hydrogel-Based Biosensors for Cancer Detection

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(36), С. 46988 - 47002

Опубликована: Авг. 27, 2024

Early cancer detection is crucial for effective treatment, but current methods have limitations. Novel biomaterials, such as hydrogels, offer promising alternatives developing biosensors detection. Hydrogels are three-dimensional and cross-linked networks of hydrophilic polymers that properties similar to biological tissues. They can be combined with various achieve high sensitivity, specificity, stability. This review summarizes the recent advances in hydrogel-based detection, their synthesis, applications, challenges. It also discusses implications future directions this emerging field.

Язык: Английский

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Coreactant-free aggregation-induced electrochemiluminescence system based on the novel zinc-luminol metal-organic gel for ultrasensitive detection of PiRNA-823

Biosensors and Bioelectronics, Год журнала: 2024, Номер 255, С. 116263 - 116263

Опубликована: Апрель 4, 2024

Язык: Английский

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Aggregation-induced emission materials-based Electrochemiluminescence emitters for sensing applications: Progress, challenges and perspectives

Coordination Chemistry Reviews, Год журнала: 2025, Номер 531, С. 216520 - 216520

Опубликована: Фев. 12, 2025

Язык: Английский

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Emerging trends and recent advances in MXene/MXene-based nanocomposites toward electrochemiluminescence sensing and biosensing

Biosensors and Bioelectronics, Год журнала: 2024, Номер 265, С. 116623 - 116623

Опубликована: Авг. 2, 2024

Язык: Английский

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Confinement-enhanced electrochemiluminescence by Ru(dcbpy)32+-functionalized γ-CD-MOF@COF-LZU1 porous hybrid material as micro-reactor for CYFRA 21-1 detection

Talanta, Год журнала: 2024, Номер 273, С. 125959 - 125959

Опубликована: Март 26, 2024

Язык: Английский

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Hydrogel-innovated nanotechnologies for chemical and biological analysis

Coordination Chemistry Reviews, Год журнала: 2024, Номер 511, С. 215874 - 215874

Опубликована: Апрель 21, 2024

Язык: Английский

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