Asian Journal of Pharmaceutical Sciences,
Год журнала:
2023,
Номер
18(5), С. 100852 - 100852
Опубликована: Сен. 1, 2023
How
to
effectively
transform
the
pro-oncogenic
tumor
microenvironments
(TME)
surrounding
a
into
an
anti-tumoral
never
fails
attract
people
study.
Small
interfering
RNA
(siRNA)
is
considered
one
of
most
noteworthy
research
directions
that
can
regulate
gene
expression
following
process
known
as
interference
(RNAi).
The
about
siRNA
delivery
targeting
cells
and
TME
has
been
on
rise
in
recent
years.
Using
drugs
silence
critical
proteins
was
efficient
solutions.
However,
manufacture
system
faces
three
major
obstacles,
i.e.,
appropriate
cargo
protection,
accurately
targeted
delivery,
site-specific
release.
In
review,
we
summarized
pharmacological
actions
remolding
TME.
addition,
strategies
combination
therapy
with
remodel
are
thoroughly
discussed.
meanwhile,
advancements
development
all
clinically
investigated
commercialized
technologies
also
presented.
Ultimately,
propose
nanoparticle
drug
may
be
future
focus
oncogene
therapy.
This
summary
offers
thorough
analysis
roadmap
for
general
readers
working
field.
Abstract
Cancer
is
a
grievous
disease
whose
treatment
requires
more
efficient,
non-invasive
therapy,
associated
with
minimal
side
effects.
Gold
nanoparticles
possessing
greatly
impressive
optical
properties
have
been
forerunner
in
bioengineered
cancer
therapy.
This
theranostic
system
has
gained
immense
popularity
and
finds
its
application
the
field
of
molecular
detection,
biological
imaging,
cell
targeting,
etc.
The
photothermal
property
nanoparticles,
especially
gold
nanorods,
causes
absorption
light
incident
by
source,
transforms
it
into
heat,
resulting
tumor
destruction.
review
describes
different
features
summarizes
advance
research
done
for
precisely
nanorods
combating
various
cancers
including
breast,
lung,
colon,
oral,
prostate,
pancreatic
cancer.
Pharmaceutics,
Год журнала:
2022,
Номер
14(12), С. 2728 - 2728
Опубликована: Дек. 6, 2022
Research
on
the
use
of
biodegradable
polymers
for
drug
delivery
has
been
ongoing
since
they
were
first
used
as
bioresorbable
surgical
devices
in
1980s.
For
tissue
engineering
and
delivery,
polymer
poly-lactic-co-glycolic
acid
(PLGA)
shown
enormous
promise
among
all
biomaterials.
PLGA
are
a
family
FDA-approved
that
physically
strong
highly
biocompatible
have
extensively
studied
vehicles
drugs,
proteins,
macromolecules
such
DNA
RNA.
wide
range
erosion
times
mechanical
properties
can
be
modified.
Many
innovative
platforms
widely
created
development
methods
controlled
PLGA.
In
this
paper,
various
manufacturing
processes
characteristics
impact
their
breakdown
release
explored
depth.
Besides
different
PLGA-based
nanoparticles,
preclinical
clinical
applications
diseases
platform
types
scale-up
issues
will
discussed.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2023,
Номер
10
Опубликована: Янв. 11, 2023
Polymer
grafting
is
a
technique
to
improve
the
morphology,
chemical,
and
physical
properties
of
polymer.
This
has
potential
existing
conduction
polymers
other
than
charge
transport;
as
result,
it
enhances
solubility,
nano-dimensional
biocompatibility,
bio-communication,
property
parent
A
polymer’s
physicochemical
can
be
modified
even
further
by
creating
copolymer
with
another
polymer
or
grafting.
Here
in
various
chemical
approaches
for
grafting,
like
free
radical,
click
reaction,
amide
formation,
alkylation
have
been
discussed
their
importance,
moreover
process
its
importance
are
covered
comprehensively
scientific
explanation.
The
present
review
also
covers
effectiveness
graft-to
application
fields,
which
will
give
reader
glimpse
about
uses.
Cancers,
Год журнала:
2023,
Номер
15(8), С. 2256 - 2256
Опубликована: Апрель 12, 2023
Cancer
is
one
of
the
most
prevalent
diseases
globally
and
second
major
cause
death
in
United
States.
Despite
continuous
efforts
to
understand
tumor
mechanisms
various
approaches
taken
for
treatment
over
decades,
no
significant
improvements
have
been
observed
cancer
therapy.
Lack
specificity,
dose-related
toxicity,
low
bioavailability,
lack
stability
chemotherapeutics
are
hindrances
treatment.
Nanomedicine
has
drawn
attention
many
researchers
due
its
potential
tumor-specific
delivery
while
minimizing
unwanted
side
effects.
The
application
these
nanoparticles
not
limited
just
therapeutic
uses;
some
them
shown
extremely
promising
diagnostic
potential.
In
this
review,
we
describe
compare
types
their
role
advancing
We
further
highlight
nanoformulations
currently
approved
therapy
as
well
under
different
phases
clinical
trials.
Finally,
discuss
prospect
nanomedicine
management.
Pancreatic
cancer
(PC)
is
a
fatal
disease
that
has
poor
5-year
survival
rate.
The
prognosis
can
be
attributed
to
both
troublesome
detections
at
the
initial
stage,
which
makes
majority
of
treatment
options
largely
unsuccessful
and
leads
extensive
metastasis,
as
well
its
distinct
pathophysiological
characteristics,
such
rich
desmoplastic
tumours
bounded
by
dysplastic
hypo
perfused
vessels
restricting
mobility
therapeutic
agents.
Continued
attempts
have
been
made
utilise
innovative
measures
for
battling
PC
increase
effectiveness
therapies
overcome
their
cytotoxicity.
Combined
targeting
gene
silencing
approach
shown
improved
outcomes
in
patients'
rates
quality
life,
offering
potential
solution
complications.
It
particularly
targets
various
barriers
alleviate
delivery
problems
diminish
tumour
recurrence
metastasis.
While
aptamers,
type
single-stranded
nucleic
acids
with
strong
binding
affinity
specificity
target
molecules,
recently
surfaced
viable
strategy,
siRNA
interfere
expression
certain
genes.
By
concurrently
suppressing
genes
boosting
targeted
approach,
cocktail
siRNA/Aptamer
other
drugs
circumvent
multi-drug
resistance
phenomena.
Additionally,
combination
therapy
additive
or
synergistic
effects
considerably
efficacy
anti-cancer
medications.
This
study
outlines
primary
difficulties
treating
PC,
along
recent
developments
mediated
drug
solve
major
hiccup
oncology
field.
