European Polymer Journal, Год журнала: 2022, Номер 184, С. 111784 - 111784
Опубликована: Дек. 20, 2022
Язык: Английский
Molecular Cancer, Год журнала: 2023, Номер 22(1)
Опубликована: Янв. 12, 2023
Skin cancer has emerged as the fifth most commonly reported in world, causing a burden on global health and economy. The enormously rising environmental changes, industrialization, genetic modification have further exacerbated skin statistics. Current treatment modalities such surgery, radiotherapy, conventional chemotherapy, targeted therapy, immunotherapy are facing several issues related to cost, toxicity, bioavailability thereby leading declined anti-skin therapeutic efficacy poor patient compliance. In context of overcoming this limitation, nanotechnological advancements been witnessed so far. Among various nanomaterials, nanoparticles endowed exorbitant advantages by acting both agents drug carriers for remarkable cancer. small size large surface area volume ratio escalate tumor uptake through their leaky vasculature resulting enhanced efficacy. context, present review provides up date information about different types pathology cancer, followed current associated drawbacks. Furthermore, it meticulously discusses role numerous inorganic, polymer, lipid-based therapy with subsequent descriptions patents clinical trials.
Язык: Английский
Процитировано
201
Molecular Cancer, Год журнала: 2023, Номер 22(1)
Опубликована: Июнь 21, 2023
Abstract Cancer is a grievous disease whose treatment requires more efficient, non-invasive therapy, associated with minimal side effects. Gold nanoparticles possessing greatly impressive optical properties have been forerunner in bioengineered cancer therapy. This theranostic system has gained immense popularity and finds its application the field of molecular detection, biological imaging, cell targeting, etc. The photothermal property nanoparticles, especially gold nanorods, causes absorption light incident by source, transforms it into heat, resulting tumor destruction. review describes different features summarizes advance research done for precisely nanorods combating various cancers including breast, lung, colon, oral, prostate, pancreatic cancer.
Язык: Английский
Процитировано
170
Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)
Опубликована: Авг. 12, 2024
Cancer remains a significant risk to human health. Nanomedicine is new multidisciplinary field that garnering lot of interest and investigation. shows great potential for cancer diagnosis treatment. Specifically engineered nanoparticles can be employed as contrast agents in diagnostics enable high sensitivity high-resolution tumor detection by imaging examinations. Novel approaches labeling are also made possible the use nanoprobes nanobiosensors. The achievement targeted medication delivery therapy accomplished through rational design manufacture nanodrug carriers. Nanoparticles have capability effectively transport medications or gene fragments tissues via passive active targeting processes, thus enhancing treatment outcomes while minimizing harm healthy tissues. Simultaneously, context radiation sensitization photothermal enhance therapeutic efficacy malignant tumors. This review presents literature overview summary how nanotechnology used According oncological diseases originating from different systems body combining pathophysiological features cancers at sites, we most recent developments applications. Finally, briefly discuss prospects challenges cancer.
Язык: Английский
Процитировано
106
European Polymer Journal, Год журнала: 2023, Номер 187, С. 111898 - 111898
Опубликована: Фев. 13, 2023
Язык: Английский
Процитировано
69
Journal of Drug Delivery Science and Technology, Год журнала: 2023, Номер 82, С. 104371 - 104371
Опубликована: Март 15, 2023
Язык: Английский
Процитировано
52
Molecular Cancer, Год журнала: 2023, Номер 22(1)
Опубликована: Янв. 12, 2023
Pancreatic cancer (PC) is a fatal disease that has poor 5-year survival rate. The prognosis can be attributed to both troublesome detections at the initial stage, which makes majority of treatment options largely unsuccessful and leads extensive metastasis, as well its distinct pathophysiological characteristics, such rich desmoplastic tumours bounded by dysplastic hypo perfused vessels restricting mobility therapeutic agents. Continued attempts have been made utilise innovative measures for battling PC increase effectiveness therapies overcome their cytotoxicity. Combined targeting gene silencing approach shown improved outcomes in patients' rates quality life, offering potential solution complications. It particularly targets various barriers alleviate delivery problems diminish tumour recurrence metastasis. While aptamers, type single-stranded nucleic acids with strong binding affinity specificity target molecules, recently surfaced viable strategy, siRNA interfere expression certain genes. By concurrently suppressing genes boosting targeted approach, cocktail siRNA/Aptamer other drugs circumvent multi-drug resistance phenomena. Additionally, combination therapy additive or synergistic effects considerably efficacy anti-cancer medications. This study outlines primary difficulties treating PC, along recent developments mediated drug solve major hiccup oncology field.
Язык: Английский
Процитировано
50
Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 97, С. 105770 - 105770
Опубликована: Май 11, 2024
Язык: Английский
Процитировано
24
Heliyon, Год журнала: 2023, Номер 9(11), С. e21227 - e21227
Опубликована: Окт. 20, 2023
The past decade has witnessed a breakthrough in novel strategies to treat cancer. One of the most common cancer treatment modalities is chemotherapy which involves administering anti-cancer drugs body. However, these can lead undesirable side effects on healthy cells. To overcome this challenge and improve cell targeting, many nanocarriers have been developed deliver directly cancerous cells minimize tissues. majority research studies conclude that, using encapsulated much safer more effective alternative than delivering drug alone its free form. This review provides summary types mainly studied for delivery, namely: liposomes, polymeric micelles, dendrimers, magnetic nanoparticles, mesoporous gold carbon nanotubes quantum dots. In review, synthesis, applications, advantages, disadvantages, previous nanomaterials are discussed detail. Furthermore, future opportunities possible challenges translating materials into clinical applications also reported.
Язык: Английский
Процитировано
38
Pharmaceutics, Год журнала: 2023, Номер 15(2), С. 398 - 398
Опубликована: Янв. 24, 2023
The formulation of nanoscale systems with well-defined sizes and shapes is great interest in applications such as drug gene delivery, diagnostics imaging. Dendrimers are polymers that have attracted due to their size, shape, branching length, amine density, surface functionalities. These unique characteristics dendrimers set them apart from other polymers, ability modify nanoparticles (NPs) for biomedical applications. spherical multiple layers over central core, each representing a generation. Their amphiphilic nature hollow structure allow the incorporation drugs or genes, addition enabling easy modification cellular receptor-targeting moieties ensure site-specific delivery therapeutics. employed chemotherapeutic anticancer drugs. There many inorganic NPs currently being investigated cancer therapy, own biological, chemical, physical properties. To favor applications, require suitable stability, biodegradability target specificity. success dependent on structure, good bioavailability stability. In this review, we describe properties use modifiers enhanced therapeutic delivery. Herein, review significant developments area 2015 2022. Databases including Web Science, Scopus, Google Scholar, Science Direct, BioMed Central (BMC), PubMed were searched articles using dendrimers, keywords.
Язык: Английский
Процитировано
34
International Journal of Pharmaceutics, Год журнала: 2023, Номер 638, С. 122938 - 122938
Опубликована: Апрель 8, 2023
Язык: Английский
Процитировано
34