BioNanoScience, Год журнала: 2024, Номер 15(1)
Опубликована: Дек. 17, 2024
Язык: Английский
Drug Development and Industrial Pharmacy, Год журнала: 2025, Номер unknown, С. 1 - 12
Опубликована: Янв. 16, 2025
The objective of the study was to tackle recurrence prostate cancer (PCa) post-surgery and re-sensitize docetaxel (DTX)-resistant PC-3 cells chemo-therapy using NIC. Prolonged DTX therapy leads emergence chemo-resistance by overexpression PI3K-AKT pathway in PCa along with tumor post-surgery. Suppression this could be essential improving anticancer activity re-sensitizing resistant cells. Niclosamide (NIC), an anthelmintic drug has shown tremendous potential re-sensitized various drugs. To mitigate post-surgical recurrence, implant-based system facilitating sustained release NIC beneficial. were incorporated within a nanofiber (NF) prevent on-site local DTX-resistant fabricated DTX-NIC NF via electrospinning 334 ± 96.14 nm diameter demonstrated profile till 6 d. Elevated mitochondrial damage, reactive oxygen species levels apoptotic index revealed improvement cytotoxicity post incorporation into owing their profile. Re-sensitization PC-3/DTX observed introduction which due suppression p-Akt1, overexpressed From superior re-sensitization cells, we conclude that beneficial therapeutic regimen preventing PCa.
Язык: Английский
Процитировано
10
BioNanoScience, Год журнала: 2025, Номер 15(2)
Опубликована: Фев. 5, 2025
Язык: Английский
Процитировано
8
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 140316 - 140316
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 99, С. 105977 - 105977
Опубликована: Июль 14, 2024
Язык: Английский
Процитировано
9
Materials, Год журнала: 2024, Номер 17(16), С. 3916 - 3916
Опубликована: Авг. 7, 2024
This manuscript explores the multifaceted applications of polydopamine (PDA) across various scientific and industrial domains. It covers chemical aspects PDA its potential in bone tissue engineering, implant enhancements, cancer treatment, nanotechnology. The investigates PDA’s roles cell culture technologies, surface modifications, drug delivery systems, sensing techniques. Additionally, it highlights contributions to microfabrication, nanoengineering, environmental applications. Through detailed testing assessment, study identifies limitations PDA-related research, such as synthesis complexity, incomplete mechanistic understanding, biocompatibility variability. also proposes future research directions aimed at improving techniques, expanding biomedical applications, enhancing technologies optimize efficacy scalability.
Язык: Английский
Процитировано
6
Brain Research, Год журнала: 2024, Номер unknown, С. 149411 - 149411
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
6
Applied Materials Today, Год журнала: 2024, Номер 38, С. 102162 - 102162
Опубликована: Март 21, 2024
Язык: Английский
Процитировано
5
Drug Delivery and Translational Research, Год журнала: 2024, Номер unknown
Опубликована: Май 2, 2024
Язык: Английский
Процитировано
3
Drug Development and Industrial Pharmacy, Год журнала: 2025, Номер unknown, С. 1 - 17
Опубликована: Май 22, 2025
The objective of the current study is to combat breast cancer-associated metastasis using paclitaxel (PTX) and tranilast (TRA)-loaded human serum albumin (HAS) Nanoparticles. This combinatorial therapy microtubule stabilizing agent PTX, along with TGFβ inhibitor TRA.TRA may offer an improved therapeutic effect in cancer by inhibiting cell proliferation metastasis. Inspired remarkable anticancer properties both drugs, they were encapsulated into HSA nanoparticles enhance tumor site-specific drug accumulation ensure sustained release over a prolonged period. fabricated desolvation method optimized Box-Behnken design (BBD) three-level, two-factor approach. Further, these characterized TEM, FTIR, XRD, particle size. In vitro experiments conducted MDA-MB-231 line, employing viability, cellular uptake, nuclear staining, scratch assay, cycle analysis. kinetics reveal PTX TRA from nanoparticles. Wound healing assay depicted anti-migratory activity PTX-TRA-NPs (30nM-75μM). Furthermore, novel combination treatment caused G2/M phase arrest, as indicated delivery hydrophobic drugs (PTX TRA) cells, offering outcomes. strategy permits further preclinical investigation for synergistic management.
Язык: Английский
Процитировано
0
Pharmaceutics, Год журнала: 2024, Номер 16(12), С. 1536 - 1536
Опубликована: Дек. 1, 2024
Background: The effectiveness of paclitaxel (PTX) in treating non-small-cell lung carcinoma (NSCLC) is restricted by its poor pharmacokinetic profile and side effects. This limitation stems from the lack a suitable delivery vector to efficiently target cancer cells. Therefore, there critical need develop an efficient carrier for optimised PTX NSCLC therapy. Methods: present study describes fabrication mesoporous polydopamine (mPDA) nano-bowls via emulsion-induced interfacial anisotropic assembly method, designed entrapment pH-responsive release behaviour. Results: depicted typical bowl-like shape, with connecting channels central hollow cavity, allowing optimal loading PTX. fabricated nanocarrier system, mPDA-PTX-nb, had mean hydrodynamic bowl diameter 200.4 ± 5.2 nm surface charge −39.2 1.3 mV. efficiency within was found be 95.7%, corresponding 85.1% achieved at acidic pH 5.9 (simulated tumour microenvironment) 48 h. Drug best fitted Peppas–Sahlin model, indicating involvement both diffusion relaxation mechanisms. Treatment mPDA-PTX-nb significantly suppressed A549 cell proliferation 72 h, resulting viability 14.0% 9.3%, respectively, highest concentration (100 µg/mL). Conclusions: These results highlight potential as effective PTX, promoting enhanced anti-proliferative effects
Язык: Английский
Процитировано
1