Phase separation in DNA damage response: New insights into cancer development and therapy
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer,
Год журнала:
2024,
Номер
1879(6), С. 189206 - 189206
Опубликована: Ноя. 1, 2024
Язык: Английский
Deciphering disulfidptosis: Uncovering a lncRNA-based signature for prognostic assessment, personalized immunotherapy, and therapeutic agent selection in lung adenocarcinoma patients
Cellular Signalling,
Год журнала:
2024,
Номер
117, С. 111105 - 111105
Опубликована: Фев. 16, 2024
Язык: Английский
Elucidating the Role of Liquid-Liquid Phase Separation in Hepatocellular carcinoma: From Single-Cell Analysis to Prognostic Biomarkers
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 27, 2024
Abstract
Background
The
function
of
liquid-liquid
phase
separation
(LLPS)
in
the
progression
hepatocellular
carcinoma
(HCC)
is
still
elusive.
We
aimed
to
explore
predictive
value
and
immuno-therapeutic
responses
LLPS-related
signature
(LLPSRS)
HCC.
Methods
In
our
study,
we
delved
into
characteristics
LLPS
at
multiple
omics
levels.
By
utilizing
single-cell
transcriptome
analysis,
applied
lasso-cox
identify
LLPSRS.
order
enhance
practicality
LLPSRS,
established
externally
validated
a
LLPSRS
nomogram,
providing
quantitative
prognostic
tool
for
HCC
patients.
Furthermore,
investigated
mechanism
according
transcriptome,
genomic,
levels,
revealing
important
connections
between
prognosis,
immune
landscape.
Finally,
examined
different
risk
subgroups
checkpoint
inhibitors
their
sensitivity
major
targeted
drugs.
Results
Using
TCGA
data
LASSO-COX
regression
A
risk-predictive
scoring
model
9
was
developed.
high-risk
group
exhibited
notably
lower
overall
survival
compared
low-risk
group.
High
AUC
values
from
time-dependent
ROC
curves
demonstrated
model's
robust
performance.
nomogram
that
integrated
score
clinical
features
showed
excellent
ability.
GO
KEGG
analyses
identified
potential
pathways
gene
signature.
signature's
associations
with
clinicopathological
characteristics,
tumor
microenvironment,
immunotherapy
response,
chemotherapy
underscored
its
significant
relevance.
Conclusion
This
accurately
predicts
outcomes
patients
uncovers
mechanisms
HCC,
paves
new
avenues
personalized
treatment
immuno-therapy
development.
Язык: Английский
Liquid–liquid phase separation in hepatocellular carcinoma
Frontiers in Cell and Developmental Biology,
Год журнала:
2024,
Номер
12
Опубликована: Дек. 24, 2024
Liquid-liquid
phase
separation
(LLPS)
drives
the
formation
of
membraneless
intracellular
compartments
within
both
cytoplasm
and
nucleus.
These
can
form
distinct
physicochemical
environments,
in
particular
display
different
concentrations
proteins,
RNA,
macromolecules
compared
to
surrounding
cytosol.
Recent
studies
have
highlighted
significant
role
aberrant
LLPS
cancer
development
progression,
impacting
many
core
processes
such
as
oncogenic
signalling
pathways,
transcriptional
dysregulation,
genome
instability.
In
hepatocellular
carcinoma
(HCC),
biomolecular
condensates
has
been
observed
a
number
preclinical
models,
highlighting
their
significance
an
emerging
factor
understanding
biology
its
molecular
underpinnings.
this
review,
we
summarize
evidence
recent
advances
HCC,
with
focus
on
regulation
dysregulation
cytoplasmic
nuclear
cells.
We
finally
discuss
how
HCC
opens
up
new
potential
treatment
avenues.
Язык: Английский