Recent advances in two-dimensional nanomaterials for bone tissue engineering

Journal of Materiomics, Год журнала: 2023, Номер 9(5), С. 930 - 958

Опубликована: Март 31, 2023

Over the last decades, bone tissue engineering has increasingly become a research focus in field of biomedical engineering, which biomaterials play an important role because they can provide both biomechanical support and osteogenic microenvironment process regeneration. Among these biomaterials, two-dimensional (2D) nanomaterials have recently attracted considerable interest owing to their fantastic physicochemical biological properties including great biocompatibility, excellent capability, large specific surface area, outstanding drug loading capacity. In this review, we summarize state-of-the-art advances 2D for engineering. Firstly, introduce most explored used advantages. We then highlight cutting-edge such as graphene its derivatives, layered double hydroxides, black phosphorus, transition metal dichalcogenides, montmorillonite, hexagonal boron nitride, graphite phase carbon carbonitrides (MXenes) Finally, current challenges future prospects regeneration clinical translation are discussed.

Язык: Английский

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Self-assembled albumin nanoparticles induce pyroptosis for photodynamic/photothermal/immuno synergistic therapies in triple-negative breast cancer

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Май 25, 2023

Triple-negative breast cancer (TNBC) is characterized by a high degree of malignancy, early metastasis, limited treatment, and poor prognosis. Immunotherapy, as new most promising treatment for cancer, has efficacy in TNBC because the immunosuppressive tumor microenvironment (TME). Inducing pyroptosis activating cyclic guanosine monophosphate-adenosine monophosphate synthase/interferon gene stimulator (cGAS/STING) signaling pathway to upregulate innate immunity have become an emerging strategy enhancing immunotherapy. In this study, albumin nanospheres were constructed with photosensitizer-IR780 encapsulated core cGAS–STING agonists/H 2 S producer-ZnS loaded on shell (named IR780-ZnS@HSA). vitro , IR780-ZnS@HSA produced photothermal therapy (PTT) photodynamic (PDT) effects. addition, it stimulated immunogenic cell death (ICD) activated cells via caspase-3–GSDME pathway. also The two pathways synergistically boost immune response. vivo + laser significantly inhibited growth 4T1 tumor-bearing mice triggered response, improving anti-APD-L1 antibody (aPD-L1). conclusion, IR780-ZnS@HSA, novel inducer pyroptosis, can inhibit improve aPD-L1.

Язык: Английский

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Emerging 2D Nanomaterials‐Integrated Hydrogels: Advancements in Designing Theragenerative Materials for Bone Regeneration and Disease Therapy

Advanced Science, Год журнала: 2024, Номер 11(31)

Опубликована: Июнь 14, 2024

Abstract This review highlights recent advancements in the synthesis, processing, properties, and applications of 2D‐material integrated hydrogels, with a focus on their performance bone‐related applications. Various synthesis methods types 2D nanomaterials, including graphene, graphene oxide, transition metal dichalcogenides, black phosphorus, MXene are discussed, along strategies for incorporation into hydrogel matrices. These composite hydrogels exhibit tunable mechanical high surface area, strong near‐infrared (NIR) photon absorption controlled release capabilities, making them suitable range regeneration therapeutic In cancer therapy, 2D‐material‐based show promise photothermal photodynamic therapies, drug delivery (chemotherapy). The properties these materials enable selective tumor ablation upon NIR irradiation, while drug‐loading capacity facilitates targeted chemotherapeutic agents. Additionally, 2D‐materials ‐infused potent antibacterial activity, effective against multidrug‐resistant infections disruption biofilm generated implant surface. Moreover, synergistic therapy approach combines multiple treatment modalities such as photothermal, chemo, immunotherapy to enhance outcomes. bio‐imaging, serve versatile contrast agents imaging probes, enabling real‐time monitoring during imaging. Furthermore, bone regeneration, most incorporated promote osteogenesis tissue offering potential solutions defects repair. Overall, integration presents promising platform developing multifunctional theragenerative biomaterials.

Язык: Английский

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Tumor microenvironment-responsive thermoelectric scaffold for on-demand antitumor therapy

Materials Today Chemistry, Год журнала: 2024, Номер 43, С. 102455 - 102455

Опубликована: Дек. 10, 2024

Язык: Английский

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Supramolecular hydrogel-loaded Prussian blue nanoparticles with photothermal and ROS scavenging ability for tumor postoperative treatments

Composites Part B Engineering, Год журнала: 2022, Номер 237, С. 109872 - 109872

Опубликована: Апрель 5, 2022

Язык: Английский

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Recent advances on injectable nanocomposite hydrogels towards bone tissue rehabilitation

Journal of Applied Polymer Science, Год журнала: 2022, Номер 140(4)

Опубликована: Ноя. 15, 2022

Abstract There has been significant interest in the recent past to develop injectable hydrogel scaffolds that follow minimally invasive implantation procedures towards efficient healing and regeneration of defective bone tissues. Such offer several advantages, as they can be injected into irregularly shaped defect act a low‐density aqueous reservoir, incorporating necessary components for tissue repair augmentation. Considering is biocomposite natural biopolymer bioapatite nanofiller, there growing trend nanocomposite by combining biopolymers inorganic nanofillers biomimic hierarchical nanostructure composition bone. Furthermore, tailored have patient‐specific properties, which lead better biological responses. The present article begins with introduction, followed an overview polymer matrices, property requirements, crosslinking techniques employed hydrogels. Various strategies composites, emphasis on hydrogels bioinert bioactive discussed. fundamental challenges related development research efforts directed solving these problems also reviewed. Finally, future trends conclusions new generation discussed this article.

Язык: Английский

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Two Hawks with One Arrow: A Review on Bifunctional Scaffolds for Photothermal Therapy and Bone Regeneration

Nanomaterials, Год журнала: 2023, Номер 13(3), С. 551 - 551

Опубликована: Янв. 29, 2023

Despite the significant improvement in survival rate of cancer patients, total cure bone is still a knotty clinical challenge. Traditional surgical resectionof tumors less than satisfactory, which inevitably results defects and inevitable residual tumor cells. For purpose realizing minimal invasiveness local curative effects, photothermal therapy (PTT) under irradiation near-infrared light has made extensive progress ablating tumors, various therapeutic agents (PTAs) for treatment have thus been reported past few years, tended to focus on osteogenic bio-scaffolds modified with PTAs order break through limitation that PTT lacks, capacity. These so-called bifunctional scaffolds simultaneously ablate generate new tissues at defects. This review summarizes recent application puts forward some practical constraints future perspectives regeneration: two hawks one arrow.

Язык: Английский

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Recent trends in bone defect repair and bone tissue regeneration of the two-dimensional material MXene

Ceramics International, Год журнала: 2023, Номер 49(12), С. 19578 - 19594

Опубликована: Март 11, 2023

Язык: Английский

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Mechanical properties of hierarchical lattice via strain gradient homogenization approach

Composites Part B Engineering, Год журнала: 2023, Номер 271, С. 111153 - 111153

Опубликована: Дек. 23, 2023

Язык: Английский

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Co-delivery of Zn ions and resveratrol via bioactive glass-integrated injectable microspheres for postoperative regeneration of bone tumor defects

Composites Part B Engineering, Год журнала: 2024, Номер 272, С. 111220 - 111220

Опубликована: Янв. 11, 2024

Язык: Английский

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