Latest Research of Doped Hydroxyapatite for Bone Tissue Engineering

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(17), С. 13157 - 13157

Опубликована: Авг. 24, 2023

Bone tissue engineering has attracted great interest in the last few years, as frequency of tissue-damaging or degenerative diseases increased exponentially. To obtain an ideal treatment solution, researchers have focused on development optimum biomaterials to be applied for enhancement bioactivity and regeneration process, which are necessary support proper healing process osseous tissues. In this regard, hydroxyapatite (HA) been most widely used material biomedical field due its biocompatibility similarity with native apatite from human bone. However, HA still presents some deficiencies related mechanical properties, essential load-bearing applications. Bioactivity is another vital property further improve antibacterial activity. These drawbacks can solved by doping trace elements, adapting properties material, and, finally, sustaining bone without occurrence implant failure. Considering these aspects, review, we presented general information about synthesis methods, applications, necessity addition ions into structure. Also, their influence HA, well latest applications doped materials field.

Язык: Английский

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An adaptive biodegradable zinc alloy with bidirectional regulation of bone homeostasis for treating fractures and aged bone defects

Bioactive Materials, Год журнала: 2024, Номер 38, С. 207 - 224

Опубликована: Май 6, 2024

Healing of fractures or bone defects is significantly hindered by overactivated osteoclasts and inhibited osteogenesis in patients with abnormal metabolism. Current clinical approaches using titanium alloys stainless steel provide mechanical support but have no biological effects on regeneration. Therefore, designing fabricating degradable metal materials sufficient strength bidirectional regulation both osteoblasts a substantial challenge. Here, this study first reported an adaptive biodegradable Zn-0.8 Mg alloy homeostasis, which promotes osteogenic differentiation activating the Pi3k/Akt pathway inhibits osteoclast inhibiting GRB2/ERK pathway. The

Язык: Английский

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Graphene Production and Biomedical Applications: A Review

Crystals, Год журнала: 2023, Номер 13(10), С. 1413 - 1413

Опубликована: Сен. 23, 2023

Graphene is a two-dimensional nanomaterial composed of carbon atoms with sp2 hybrid orbitals. Both graphene and graphene-based composite have gained broad interest among researchers because their outstanding physiochemical, mechanical, biological properties. production techniques are divided into top-down bottom-up synthesis methods, which chemical vapor deposition (CVD) the most popular. The biomedical applications its include use in sensors, implantology, gene drug delivery. They can be used for tissue engineering, anticancer therapies, as antimicrobial agents implant application. biocompatibility nanomaterials enables field biomedicine. This article reviews properties graphene, methods to produce it, challenges associated use, potential this material biomedicine, regenerative medicine, delivery systems.

Язык: Английский

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Fabrication of alginate composite hydrogel encapsulated retinoic acid and nano Se doped biphasic CaP to augment in situ mineralization and osteoimmunomodulation for bone regeneration

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 275, С. 133597 - 133597

Опубликована: Июль 1, 2024

Язык: Английский

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Challenges and Opportunities in Engineering of Next Generation 3D Microelectronic Devices: Improved Performance, Higher Integration Density

Nanoscale Advances, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

In recent years, nanotechnology and materials science have evolved matured, making it increasingly easier to design fabricate next-generation 3D microelectronics.

Язык: Английский

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3D Printing and Electrospinning of Drug- and Graphene-Enhanced Polycaprolactone Scaffolds for Osteochondral Nasal Repair

Materials, Год журнала: 2025, Номер 18(8), С. 1826 - 1826

Опубликована: Апрель 16, 2025

A novel bi-layered scaffold, obtained via 3D printing and electrospinning, was designed to improve osteochondral region reconstruction. The upper electrospun membrane will act as a barrier against unwanted tissue infiltration, while the lower 3D-printed layer provide porous structure for ingrowth. Graphene integrated into scaffold its antibacterial properties, drug Osteogenon® (OST) added promote bone regeneration. composite scaffolds were subjected comprehensive physical, thermal, mechanical evaluations. Additionally, their biological functionality assessed by means of NHAC-kn cells. 0.5% graphene addition PCL significantly increased strain at break, enhancing material ductility. GNP also acted an effective nucleating agent, raising crystallization temperatures supporting mineralization. high surface area facilitated rapid apatite formation attracting calcium phosphate ions. This confirmed FTIR, µCT SEM analyses, which highlighted positive impact on mineral deposition. synergistic interaction between nanoplatelets created bioactive environment that enhanced cell adhesion proliferation, promoted superior formation. These findings highlight scaffold’s potential promising biomaterial repair regenerative medicine.

Язык: Английский

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Synthesis of TiO2/rGO composite coatings on titanium alloys with enhanced anticorrosion performance in palmitic acid-incorporated physiological solutions

Ceramics International, Год журнала: 2023, Номер 49(21), С. 33598 - 33606

Опубликована: Авг. 3, 2023

Язык: Английский

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Biomedical Applications of Hybrid Nanomaterials

Advances in chemical and materials engineering book series, Год журнала: 2024, Номер unknown, С. 170 - 225

Опубликована: Янв. 25, 2024

The ever-evolving field of nanotechnology has led to groundbreaking advancements in biomedical science, particularly through the development hybrid nanomaterials. This chapter explores synthesis, characterization, and diverse applications these materials, which combine advantageous properties both organic inorganic constituents for optimized functionality. text delves into use nanomaterials areas such as drug delivery, diagnostics, tissue engineering, biosensors. A key case study demonstrating wound-healing silver nanoparticle-loaded nanofibrous scaffolds is included. also addresses challenges ethical considerations associated with clinical translation Therefore, this serves a comprehensive guide readers interested understanding harnessing immense potential applications.

Язык: Английский

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Improving osseointegration and antimicrobial properties of titanium implants with black phosphorus nanosheets‐hydroxyapatite composite coatings for vascularized bone regeneration

Journal of Biomedical Materials Research Part B Applied Biomaterials, Год журнала: 2024, Номер 112(4)

Опубликована: Март 23, 2024

Abstract For decades, titanium implants have shown impressive advantages in bone repair. However, the preparation of with excellent antimicrobial properties as well better osseointegration ability remains difficult for clinical application. In this study, black phosphorus nanosheets (BPNSs) were doped into hydroxyapatite (HA) coatings using electrophoretic deposition. The coatings' surface morphology, roughness, water contact angle, photothermal properties, and antibacterial investigated. BP/HA coating exhibited a roughness 59.1 nm, providing an ideal substrate cell attachment growth. angle on was measured to be approximately 8.55°, indicating its hydrophilic nature. BPNSs demonstrated efficient conversion, temperature increase 42.2°C under laser irradiation. composite significant reduction bacterial growth, inhibition rates 95.6% 96.1% against Staphylococcus aureus Escherichia coli . addition, cytocompatibility evaluated by adhesion, CCK8 AM/PI staining; effect promoting angiogenesis assessed scratch assay, transwell protein blotting; osteoinductivity alkaline phosphatase alizarin red staining, Western blot. results showed that superior performance biological functions such proliferation activity, osteogenic differentiation, angiogenesis, had potential applications vascularized regeneration.

Язык: Английский

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Polyelectrolytes for Environmental, Agricultural, and Medical Applications

Polymers, Год журнала: 2024, Номер 16(10), С. 1434 - 1434

Опубликована: Май 18, 2024

In recent decades, polyelectrolytes (PELs) have attracted significant interest owing to a surge in research dedicated the development of new technologies and applications at biological level. Polyelectrolytes are macromolecules which substantial portion constituent units contains ionizable or ionic groups. These demonstrate varied behaviors across different pH ranges, strengths, concentrations, making them fascinating subjects within scientific community. The aim this review is present comprehensive survey progress application studies their derivatives various fields that vital for advancement, conservation, technological planet, including agriculture, environmental science, medicine. Through bibliographic review, we seek highlight significance these materials extensive range modern times.

Язык: Английский

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