PLoS Biology, Год журнала: 2022, Номер 20(12), С. e3001861 - e3001861

Опубликована: Дек. 15, 2022

Recent theoretical models suggest that deciding about actions and executing them are not implemented by completely distinct neural mechanisms but instead two modes of an integrated dynamical system. Here, we investigate this proposal examining how activity unfolds during a dynamic decision-making task within the high-dimensional space defined cells in monkey dorsal premotor (PMd), primary motor (M1), dorsolateral prefrontal cortex (dlPFC) as well external internal segments globus pallidus (GPe, GPi). Dimensionality reduction shows four strongest components functionally interpretable, reflecting state transition between deliberation commitment, transformation sensory evidence into choice, baseline slope rising urgency to decide. Analysis contribution each population these meaningful differences regions no clusters region, consistent with During deliberation, cortical on two-dimensional “decision manifold” falls off manifold at moment commitment choice-dependent trajectory leading movement initiation. The structure varies regions: In PMd, it is curved; M1, nearly perfectly flat; dlPFC, almost entirely confined dimension. contrast, pallidal primarily urgency. We findings reveal functional contributions different brain system governing action selection execution.

Язык: Английский